Retrospective Study of Necropsy-Associated Coagulase-Positive Staphylococci in Horses

Abstract

Abstract. Coagulase-positive staphylococci (CoPS) are potential causative agents of equine infections, but they are rarely responsible for the death of the animal. In the current study, staphylococci implicated in the death or euthanasia of horses were retrospectively studied in 3,457 necropsies performed over a decade (1995)(1996)(1997)(1998)(1999)(2000)(2001)(2002)(2003)(2004)(2005)(2006). Morbidity associated with CoPS was 1.7%, representing 60 isolates of CoPS, which were identified as Staphylococcus aureus (59) and Staphylococcus pseudintermedius (1). Coagulase-positive staphylococci (alone or in association with another bacterial species) were associated with the death or euthanasia of 90% of the cases (54/60). Proportions of antibiotic resistance to penicillin G and tetracycline reached 62.7% and 23.7%, respectively. Virulence genes were detected in 91.7% of the strains, with a majority of seh or sei enterotoxin genes. Finally, 3 methicillin-resistant Staphylococcus aureus (MRSA) isolates belonging to the t064 spa-type were identified. One strain was isolated in 2003 and might thus be one of the first cases of equine MRSA in France.

Nationwide molecular epidemiology of methicillin-resistant Staphylococcus aureus responsible for horse infections in France

“…ST8-type MRSA has also been recently isolated in Australian horses [15]. In France, only one molecular study has been performed on MRSA isolated in horses [10]. In this study, only three MRSA were identified among 59 S. aureus equine isolates and all belonged to the ST8 [10].…”

“…In France, only one molecular study has been performed on MRSA isolated in horses [10]. In this study, only three MRSA were identified among 59 S. aureus equine isolates and all belonged to the ST8 [10]. ST398-type MRSA is a non-CC8 clone initially report in France in pigs [6], which is currently spreading in horse clinics in Europe and North America [10, 12, 16].…”

“…Note that almost all equine MRSA isolates carry mecA while mecC has been rarely detected so far [6, 7]. From an epidemiological point of view, the prevalence of MRSA in horse infections has been poorly investigated in France [7, 10] and most importantly there is no data on nationwide molecular epidemiology.…”

Antimicrobial Resistance in Bacterial Pathogens of Canine Otitis

“…In Veterinary Medicine the resistance to glycopeptides has been hardly studied due to little use. According to Haenni et al (2010) Aminoglycoside class showed one of the best level of susceptibility in this study, ranging from 7.69% to 25.81%, as well as phenicols.…”

Antibacterial Characterization of Novel Synthetic Thiazole Compounds against Methicillin-Resistant Staphylococcus pseudintermedius

“…In several cases, patients that contracted an infection caused by S . pseudintermedius , in particular newborn puppies, have died or been euthanized due to the lack of effective treatment to remedy the medical condition [4, 7, 8]. Thus there is a critical need for the discovery and characterization of novel antimicrobials to treat infections caused by methicillin-sensitive and methicillin-resistant S .…”