Retrospective study of Tc-99m thyroid scan in patients with graves' disease: Is there significant difference in lobar activity?

Wagieh, Shereen; Salman, Khaled; Bakhsh, Aquib; Talaat, Omnia; Morsy, Soha Al; Al-Ezzi, Manal; Hamid, Gihad; Aljuhani, Nasser

doi:10.4103/ijnm.ijnm_186_19

Cited by 2 publications

(1 citation statement)

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“…A larger right thyroid lobe in a normal gland, and a preponderance of left lobe involvement in thyroid hemiagenesis, suggests the possibility of predominant right lobe organogenesis and functional advantages over the left [ 5 ]. Furthermore, a study evaluating lobar activity in Graves' disease with diffuse intense TC 99m uptake showed that the right thyroid lobe expressed a higher uptake than the left [ 9 ].…”

Section: Discussionmentioning

confidence: 99%

Graves' disease with only unilateral involvement; a case report

Bu Bshait

2024

International Journal of Surgery Case Reports

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Section: Discussionmentioning

confidence: 99%

Graves' disease with only unilateral involvement; a case report

Bu Bshait

2024

International Journal of Surgery Case Reports

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Remodeling^99mTc-Pertechnetate Thyroid Uptake: Statistical, Machine Learning, and Deep Learning Approaches

Currie

Iqbal

2021

J. Nucl. Med. Technol.

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Although reference ranges for 99m Tc thyroid percentage uptake vary, the seemingly intuitive evaluation of thyroid function does not reflect the complexity of thyroid pathology and biochemical status. The emergence of artificial intelligence in nuclear medicine has driven problem solving associated with logic and reasoning, warranting reexamination of established benchmarks in thyroid functional assessment. Methods: This retrospective study of 123 patients compared scintigraphic findings with grounded truth established through biochemistry status. Conventional statistical approaches were used in conjunction with an artificial neural network to determine predictors of thyroid function from data features. A convolutional neural network was also used to extract features from the input tensor (images). Results: Analysis was confounded by subclinical hyperthyroidism, primary hypothyroidism, subclinical hypothyroidism, and triiodothyronine toxicosis. Binary accuracy for identifying hyperthyroidism was highest for thyroid uptake classification using a threshold of 4.5% (82.6%), followed by pooled physician interpretation with the aid of uptake values (82.3%). Visual evaluation without quantitative values reduced accuracy to 61.0% for pooled physician determinations and 61.4% classifying on the basis of thyroid gland intensity relative to salivary glands. The machine learning (ML) algorithm produced 84.6% accuracy; however, this included biochemistry features not available to the semantic analysis. The deep learning (DL) algorithm had an accuracy of 80.5% based on image inputs alone. Conclusion: Thyroid scintigraphy is useful in identifying hyperthyroid patients suitable for radioiodine therapy when using an appropriately validated cutoff for the patient population (4.5% in this population). ML artificial neural network algorithms can be developed to improve accuracy as second-reader systems when biochemistry results are available. DL convolutional neural network algorithms can be developed to improve accuracy in the absence of biochemistry results. ML and DL do not displace the role of the physician in thyroid scintigraphy but can be used as second-reader systems to minimize errors and increase confidence.

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Retrospective study of Tc-99m thyroid scan in patients with graves' disease: Is there significant difference in lobar activity?

Cited by 2 publications

References 20 publications

Graves' disease with only unilateral involvement; a case report

Graves' disease with only unilateral involvement; a case report

Remodeling^99mTc-Pertechnetate Thyroid Uptake: Statistical, Machine Learning, and Deep Learning Approaches

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Retrospective study of Tc-99m thyroid scan in patients with graves' disease: Is there significant difference in lobar activity?

Cited by 2 publications

References 20 publications

Graves' disease with only unilateral involvement; a case report

Graves' disease with only unilateral involvement; a case report

Remodeling99mTc-Pertechnetate Thyroid Uptake: Statistical, Machine Learning, and Deep Learning Approaches

Contact Info

Product

Resources

About

Remodeling^99mTc-Pertechnetate Thyroid Uptake: Statistical, Machine Learning, and Deep Learning Approaches