Retrospective study of temperature rhythms of intensive care patients

Temperature Rhythm in Aneurysmal Subarachnoid Hemorrhage

“…Although not entirely comparable to this study population, studies of mixed brain injury [23] and intensive care patients with respiratory failure [25] have also demonstrated a variable and shifted acrophase. The critical care environment may place patients at risk for circadian rhythm disturbances, particularly shifts in acrophase, due to the loss of normal external synchronizing influences and to the use of sedating medications.…”

“…The 24-h fixed period cosinor is the most commonly used and interpretable model to describe diurnal temperature patterns in adults and is well established as an effective model for this purpose. Studies of mixed brain injury and intensive care patients support that a period of approximately 24 h is present in this group of patients [21][22][23][24][25][26]. The 24-h fixed model should thus be useful to identify overt 24-h temperature pattern disruptions that might occur as a result of brain insult and the impact of medical care, nursing care, and the intensive care clinical environment.…”

Use of 2 % propofol to produce diurnal sedation in critically ill patients

“…Temperature has a stable diurnal rhythm and is relatively immune to exogenous influences. A retrospective study 432 by Tweedie [15] in ICU patients showed 80 % of the patients retained rhythmicity of temperature, though there were marked phase shifts by as much as 12 h and this could be attributed to a weakening of the endogenous pacemaker.…”

Sleep Neurobiology and Critical Care Illness

“…45 In a recent study, Gazendam and colleagues 46 found that acrophases were shifted (advanced or delayed) in 81% of patients, but that this shift was stable across days in each individual. In contrast, in a large cohort of 137 patients investigated after thoracic or vascular surgery, core body temperature showed no circadian rhythmicity in most patients during the first 3 postoperative days.…”