Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic finding in Zhuhai Hospital, China

Kassim, Said Abasse; Abbas, Muhammad; Tang, Weiyan; Wu, Shukun; Meng, Qingdao; Zhang, Chengcheng; Naeem, Shagufta; Li, Xiaobo; Chen, Rui

doi:10.1007/s00384-019-03435-7

Cited by 22 publications

(26 citation statements)

References 26 publications

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“…description (Younes et al, 2018 ). Moreover, most of observational evidence incorrectly considers MC as a proxy of long‐term use of laxatives, specific for AQ derivatives (Kassim et al, 2020 ; Siegers, Von Hertzberg‐Lottin, Otte, & Schneider, 1993 ), but their use is only one of the factor involved in its aetiology (Yang et al, 2020 ). Actually, other causes such as irritable bowel syndrome, inflammatory bowel disease, colonic neoplasms, hyperplastic polyps, the use of nonsteroidal anti‐inflammatory drugs, vitamin E deficiency, the intake of unsaturated fatty acids, environmental factors, family history, psoriasis and Rett syndrome, feces stasis, and obstruction of colon and rectum could also contribute to the onset of MC (Yang et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Anthraquinone laxatives use and colorectal cancer: A systematic review and meta‐analysis of observational studies

Lombardi

Crescioli

Maggini

et al. 2022

Phytotherapy Research

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This systematic review and meta‐analysis were conducted to determine the effects of anthraquinone (AQ) laxatives on colorectal cancer (CRC). We searched PubMed, Embase, Google Scholar, and CENTRAL from inception until March 2021, for randomized controlled trials (RCTs) and observational studies. Through the systematic review, we identified 8 observational studies evaluating AQ laxatives use as a risk factor for CRC development, and 5 studies on CRC risk were included in the meta‐analysis using a random‐effects model. Through the meta‐analysis, we found that a history of AQ laxatives use compared with “other” and “no laxatives” use was associated with CRC development (OR: 1.41; 95% CI: 0.94–2.11), although not at a statistically significant level. The possible association persists even after removal of the outlier studies (OR: 1.51; 95% CI: 0.97–2.34). Selection of cases and controls was judged at low or unclear risk of bias across almost all studies, and the quality of evidence was from moderate to low. In conclusion, it is not possible to associate the use of AQ laxatives with the development of CRC. However, the trend toward an increased risk of CRC provides a strong indication for investigating this issue by performing further high‐quality studies.

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Section: Discussionmentioning

confidence: 99%

Anthraquinone laxatives use and colorectal cancer: A systematic review and meta‐analysis of observational studies

Lombardi

Crescioli

Maggini

et al. 2022

Phytotherapy Research

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“…The association between tumor markers and curative effect has already been studied in breast cancer, colorectal cancer, gastric cancer, pancreatic cancer, and ovarian cancer, but limited clinical studies are available to identify the role of tumor markers and response to chemotherapy in advanced stage of NSCLC (14,16,(43)(44)(45). In this study, we sought to determine the clinical potential of tumor markers in monitoring the response of patients to palliative chemotherapy.…”

Section: Discussionmentioning

confidence: 99%

Clinical Evaluation of Serum Tumor Markers in Patients With Advanced-Stage Non-Small Cell Lung Cancer Treated With Palliative Chemotherapy in China

et al. 2020

Self Cite

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This study aims to analyze the prognostic value of seven tumor makers and also investigate the response of palliative chemotherapy in advanced NSCLC patients with advanced disease. Methods: Medical records of 278 advanced NSCLC Chinese patients who received six cycles of palliative chemotherapy were retrospectively reviewed under ethical approval (JSCH2019K-011). Univariate and multivariate Cox regression analyses were performed using SPSS 24 to find the clinical value of these tumor markers and to identify the factors that were associated with progression-free survival (PFS), as well as the response to palliative chemotherapy. Results: In baseline characteristic, the high levels of CEA, CA-125, CA-199, AFP, NSE, CYFRA21-1, and CA15-3 were detected in 209 (75.18%), 139 (50.0%), 62 (22.30%), 18 (6.47%), 155 (55.75%), 176 (63.30%), and 180 (64.74%) patients, respectively. Univariate analysis revealed that patients with high vs. normal levels of all tumor markers had an increased risk of poor prognosis. In the multivariable Cox regression model, the patient with (high vs. normal) CYFRA21-1 levels (HR = 1.454, P = 0.009) demonstrated an increased poor PFS. However, patients with (high vs. normal) CA19-9 levels (HR = 0.524, P < 0.0001) and NSE levels (HR = 0.584, P < 0.0001) presented a decreased risk of PFS. Also, patients receiving 3-drugs regimen had better PFS compared to those on 2-drugs regimen (P = 0.043). Conclusions: The high levels of CYFRA21-1 was correlated with a poor prognostic factor of PFS for Advanced NSCLC patients. However, the high levels of CA19-9 and NSE were associated with a better prognostic factor of PFS. Additionally, smoking habits and tumor status had a poor prognostic factor of PFS. Moreover, we found that antiangiogenic therapy has high efficacy with first-line chemotherapy and longer PFS of NSCLC patients.

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“…Some traditional Chinese medicines also cause damage to the intestinal tract (melanosis coli). [ 23 , 24 ] Long-term improvement of constipation can be achieved through the management of patients’ cognitive behavioral patterns. Studies have shown that dietary fiber supplementation can improve chronic constipation, but there is no intervention study on constipation with a vegan diet.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness and safety of light vegetarian diet and Qingjiang Tiaochang Recipe for functional constipation

Liu

Chen

et al. 2020

Medicine

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Retrospective study on melanosis coli as risk factor of colorectal neoplasm: a 3-year colonoscopic finding in Zhuhai Hospital, China

Cited by 22 publications

References 26 publications

Anthraquinone laxatives use and colorectal cancer: A systematic review and meta‐analysis of observational studies

Anthraquinone laxatives use and colorectal cancer: A systematic review and meta‐analysis of observational studies

Clinical Evaluation of Serum Tumor Markers in Patients With Advanced-Stage Non-Small Cell Lung Cancer Treated With Palliative Chemotherapy in China

Effectiveness and safety of light vegetarian diet and Qingjiang Tiaochang Recipe for functional constipation

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