Retrospective Study on the Prevalence of Surgical Wound Infections in Specialist Hospital Sokoto – North West Nigeria

Shuaibu, A; Ibrahim, Y. K. E.; Olayinka, Busayo Olalekan; Atata, R. F.; Oyeniyi, J; Shuaibu, B

doi:10.9734/jamps/2017/31291

Cited by 3 publications

(3 citation statements)

References 12 publications

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“…Klebsiella was found in 8% culture sensitivity reports of our study while a study done in Egypt [ 18 ] the prevalence of Klebsiella was 24% and in Nigeria [ 19 ] it was 17.3%. According to a study in Egypt, Klebsiella species was 83.3% sensitive to Colistin Sulphate, 66.7% to Levofloxacin, 58.3% to Ciprofloxacin and 50% sensitive against Amikacin [ 18 ].…”

Section: Discussionsupporting

confidence: 39%

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The Emergence of Multiple Antibiotic Resistance in Culture Sensitivities of Post-surgical Patients in Lahore General Hospital, Lahore

Fatima¹,

Askri²,

Shahid³

et al. 2022

Cureus

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The purpose of this study is to isolate the organisms which are developing resistance and to recognize the drugs against which resistance has emerged so that antibiotic policy can be formulated for the proper and effective use of antibiotics. Setting and designAn observational study was conducted for a period of six months from July 1, 2021 and December 31, 2021 in LGH. MethodsStatistics regarding the culture and sensitivity of the organisms isolated from different sources were collected from the surgery department. 195 cultural and sensitivity reports were analyzed for identification of genus/species of bacteria and sensitivity of the organism. ResultsOut of 195 culture reports, 124 showed significant growth of organisms exhibiting resistance to either single or multiple drugs. Escherichia and acinobactor was the most common organism isolated with a total of 30 each (24%, 24%), followed by pseudomonas 21 (17%), Klebsiella was 13 (10%), Proteus was 10 (8%), Methicillin-resistance Staph-aureus was seven (5%), Methicillin-sensitive Staph-aureus was five (4%), Staphylococcus epidermidis was four (3%), Providencia, Streptococci, Enterobacter species and Citrobacter species were one (1%).Maximum resistance was detected with frequently used first-line antimicrobials such as Ceftriaxone, ampicillin and Clavulanic acid. Least resistant were Azithromycin, Cefoxitin, Cefaclor among the gramnegative and gram-positive bacteria. ConclusionAntimicrobial resistance (AMR) was more against frequently used antibiotics that are accessible for an extended duration. Variation of resistance and sensitivity pattern with time is identified. Periodic AMR monitoring and rotation of antibiotics are suggested to restrict further emergence of resistance.

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Section: Discussionsupporting

confidence: 39%

“…Proteus was found in 8% of culture sensitivity reports of our study while according to a study in Nigeria [19] the prevalence of Proteus was 7.7% in SSI culture sensitivity reports. In our study, Proteus was most sensitive to Cefoparazone+Salbactum 90% and Amikacin 80%.…”

Section: Table 2: Bacteria With Their Sensitivity To Antibioticscontrasting

confidence: 47%

The Emergence of Multiple Antibiotic Resistance in Culture Sensitivities of Post-surgical Patients in Lahore General Hospital, Lahore

Fatima¹,

Askri²,

Shahid³

et al. 2022

Cureus

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“…MRSA strains have also emerged in community settings, affecting otherwise healthy individuals [21]. Community-acquired MRSA can cause severe infections, such as skin and soft tissue infections, which can lead to bacteraemia and, in some cases, mortality [22]. Patients who acquire MRSA bacteraemia often have other underlying health conditions that can complicate treatment and increase the risk of mortality [23].…”

Section: N Discussionmentioning

confidence: 99%

Meta-meta-analysis of the mortality risk associated with MRSA compared to MSSA bacteraemia

2024

Infez Med

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Staphylococcus aureus bacteraemia (SAB) is a bloodstream infection that carries a high risk of exacerbating a diseased state and may result in an increased death rate. The aim of this study was to assess mortality risk in Methicillin Resistant Staphylococcus aureus (MRSA) bacteraemia compared to Methicillin Susceptible Staphylococcus aureus (MSSA) bacteraemia through metameta-analyses. The study followed PRISMA guidelines, conducting a comprehensive search in Scopus, PubMed, and Google Scholar. It included full-text systematic reviews and meta-analyses comparing MRSA vs. MSSA bacteraemia, excluding reviews without data pooling and unclear selection criteria. Validity was assessed using QUOROM and AMSTAR. Edwards' Venn diagrams were used to visualized overlaps between primary studies. Aggregated odds ratio (OR) and risk ratios with 95% confidence intervals were calculated using the random-effect model. Heterogeneity was evaluated using the Higgins I2 statistic. The study included 3 metaanalysis studies, a total of 38,159 patients, with 9,056 having MRSA bacteraemia and 29,103 having MSSA bacteraemia. Data were collected from 46 different outcome studies published between 2001 and 2022. The meta-analyses used 7 to 33 primary studies from 1990 to 2020, with no overlap. Odds ratios (ORs) ranged from 1.78 to 2.92, while relative risks (RR) ranged from 1.57 to 2.37 for the included meta-anlysis. The pooled analysis confirmed a higher risk of mortality in patients with MRSA bacteraemia (OR: 2.35, RR: 2.01, HR: 1.61) compared to MSSA bacteraemia. Heterogeneity among the studies was considerable (I2: 90-91%). The study strongly supports that most patient deaths from SAB are linked to MRSA rather than MSSA. This highlights the significant public health problem posed by SAB, with difficult and often unsuccessful treatment leading to increased mortality and high healthcare costs.

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Plasmid Curing of Bacteria Isolated from Upper Respiratory Tract Infections among Patients Attending Specialist Hospital Sokoto

Saifullahi,

Lawal,

Abdulrahman

et al. 2024

UJMR

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Study’s Novelty/Excerpt This study focuses on curing plasmid-mediated antibiotic resistance in bacteria associated with upper respiratory tract infections in patients at Specialist Hospital Sokoto, an area previously underexplored in this context. It uniquely demonstrates the successful reversal of antibiotic resistance in Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa through plasmid curing experiments, highlighting the significant role of plasmids in resistance mechanisms. Additionally, the study underscores the potential for plasmid-mediated resistance to be transferred among bacterial populations, presenting a critical concern for antimicrobial resistance management in the region. Full Abstract Presences of resistant plasmids (R-plasmids) in microorganisms make the cells avert the effect of antibiotics and complicates chemotherapy of infections. This study aimed to cure the plasmid of antibiotic-resistant bacteria associated with upper respiratory tract infections among patients attending Specialist Hospital Sokoto by reassessing their susceptibility to antibiotics that were previously resistant. One hundred (100) throat swab samples were collected and analysed. The isolates were isolated and identified using standard methods (Gram staining, biochemical and serological tests). The susceptibility of the isolates to various beta-lactam antibiotics was evaluated, and resistant bacteria were subjected to plasmid curing experiments followed by further susceptibility testing to reassess their susceptibility to the erstwhile resistance. Bacteria isolated were Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa, with the frequency of occurrence of 20 (57.2%), 9 (25.7%), and 6 (17.1%), respectively. The result of antibiotic susceptibility tests before plasmid curing showed that Staphylococcus aureus, Streptococcus pyogenes, and Pseudomonas aeruginosa resisted Cloxacilline, Cefuroxime, Cloxacillin and Augmentin. Susceptibility results after curing showed that almost all bacteria have reverted to sensitivity to all antibiotics except Cloxacillin and Augmentin. This research implies that the resistance possessed by the bacterial isolates is plasmid-mediated and may easily be transferred to other non-resistant bacteria, which may lead to an alarming rate of antimicrobial resistance in the study area.

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Retrospective Study on the Prevalence of Surgical Wound Infections in Specialist Hospital Sokoto – North West Nigeria

Cited by 3 publications

References 12 publications

The Emergence of Multiple Antibiotic Resistance in Culture Sensitivities of Post-surgical Patients in Lahore General Hospital, Lahore

The Emergence of Multiple Antibiotic Resistance in Culture Sensitivities of Post-surgical Patients in Lahore General Hospital, Lahore

Meta-meta-analysis of the mortality risk associated with MRSA compared to MSSA bacteraemia

Plasmid Curing of Bacteria Isolated from Upper Respiratory Tract Infections among Patients Attending Specialist Hospital Sokoto

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