Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination

Lozano, Yave R.; Page, Hector; Philippe, J; Lomi, Eleonora; Street, James S.; Jeffery, Kate J.

doi:10.1177/2398212817721859

Cited by 51 publications

(55 citation statements)

References 50 publications

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“…The existence of egocentric boundary cells (EBC) was proposed by Derdikman (2009), and EBC were recently identified in the entorhinal cortex (Wang et al 2018, Gofman et al 2019), postrhinal cortex (Gofman et al 2019), parasubiculum (Gofman et al 2019), striatum (Hinman et al 2019) and RSC (Alexander et al 2019). Several studies have described HDC in the RSC (Chen et al 1994a,b; Cho et al 2001; Jacob et al 2017; Lozano et al 2017). Here we found that, although 28% of RSC cells were tuned to HD, the majority of these were in fact EBC with weaker but significant responses to HD, such that only 4% of RSC cells were classified as HDC.…”

Section: Discussionmentioning

confidence: 99%

Multiplexed code of navigation variables in anterior limbic areas

Laurens

Abrego

Cham

et al. 2019

Preprint

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The brain’s navigation system integrates multimodal cues to create a sense of position and orientation. Here we used a multimodal model to systematically assess how neurons in the anterior thalamic nuclei, retrosplenial cortex and anterior hippocampus of mice, as well as in the cingulum fiber bundle and the white matter regions surrounding the hippocampus, encode an array of navigational variables when animals forage in a circular arena. In addition to coding head direction, we found that some thalamic cells encode the animal’s allocentric position, similar to place cells. We also found that a large fraction of retrosplenial neurons, as well as some hippocampal neurons, encode the egocentric position of the arena’s boundary. We compared the multimodal model to traditional methods of head direction tuning and place field analysis, and found that the latter were inapplicable to multimodal regions such as the anterior thalamus and retrosplenial cortex. Our results draw a new picture of the signals carried and outputted by the anterior thalamus and retrosplenial cortex, offer new insights on navigational variables represented in the hippocampus and its vicinity, and emphasize the importance of using multimodal models to investigate neural coding throughout the navigation system.

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Section: Discussionmentioning

confidence: 99%

Multiplexed code of navigation variables in anterior limbic areas

Laurens

Abrego

Cham

et al. 2019

Preprint

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“…HD cell firing rates can vary between different HD cells (Taube, 2007) and on average the peak firing rate can differ between recording locations within cortical-limbic regions, approximately ranging from 2 spikes/s to 120 spikes/s (Blair and Sharp, 1995;Taube and Muller, 1998;Peyrache et al, 2015;Lozano et al, 2017). Notably, ATN HD cells on average express higher firing rates compared to those recorded in PoS (Blair and Sharp, 1995;Taube and Muller, 1998;Peyrache et al, 2015) and some preliminary work indicates that the firing rates of PaS and MEC HD cells are on average lower than ATN cells (Winter et al, 2015b).…”

Section: Firing Ratementioning

confidence: 99%

A Comparison of Neural Decoding Methods and Population Coding Across Thalamo-Cortical Head Direction Cells

Winter

et al. 2019

Front. Neural Circuits

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Head direction (HD) cells, which fire action potentials whenever an animal points its head in a particular direction, are thought to subserve the animal's sense of spatial orientation. HD cells are found prominently in several thalamo-cortical regions including anterior thalamic nuclei, postsubiculum, medial entorhinal cortex, parasubiculum, and the parietal cortex. While a number of methods in neural decoding have been developed to assess the dynamics of spatial signals within thalamo-cortical regions, studies conducting a quantitative comparison of machine learning and statistical model-based decoding methods on HD cell activity are currently lacking. Here, we compare statistical model-based and machine learning approaches by assessing decoding accuracy and evaluate variables that contribute to population coding across thalamo-cortical HD cells.

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“…For instance, Clark et al (2010) showed that large lesions of the RSC can impair control over anterior thalamic head direction cell activity typically exerted by a prominent environmental landmark. Briefly, when a landmark is manipulated in an environment, limbic head direction cells maintain their orientation in relation to the cue Lozano et al, 2017;Yoder et al, 2011b). However, in animals with RSC lesions, anterior thalamic head direction cells were no longer controlled by the cue, and would adopt other orientations, perhaps in reference to other stimulus sources (Clark et al, 2010).…”

Section: Reference Frame Coding By Retrosplenial Cortical Neuronsmentioning

confidence: 99%

The retrosplenial-parietal network and reference frame coordination for spatial navigation

Clark¹,

Simmons²,

Berkowitz³

et al. 2018

Preprint

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The retrosplenial cortex is anatomically positioned to integrate sensory, motor, and visual information and is thought to have an important role in processing spatial information and guiding behavior through complex environments. Anatomical and theoretical work has argued that the retrosplenial cortex participates in spatial behavior in concert with its primary input, the parietal cortex. Although the nature of this interactions is unknown, the central position is that the functional connectivity is hierarchical with egocentric spatial information processed at parietal cortex, and higher-level allocentric mappings generated in the retrosplenial cortex. Here, we review the evidence supporting this proposal. We begin by summarizing the key anatomical features of the retrosplenial-parietal network, and then review studies investigating the neural correlates of these regions during spatial behavior. Our summary of this literature suggests that the retrosplenial-parietal circuitry does not represent a strict hierarchical parcellation of function between the two regions, but instead a heterogeneous mixture of egocentric-allocentric coding and integration across frames of reference. We also suggest that this circuitry should be represented as a gradient of egocentric-to-allocentric information processing from parietal to retrosplenial cortices, with more specialized encoding of global allocentric frameworks within the retrosplenial cortex and more specialized egocentric and local allocentric representations in parietal cortex. We conclude by identifying the major gaps in this literature and suggest new avenues of research.

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Retrosplenial and postsubicular head direction cells compared during visual landmark discrimination

Cited by 51 publications

References 50 publications

Multiplexed code of navigation variables in anterior limbic areas

Multiplexed code of navigation variables in anterior limbic areas

A Comparison of Neural Decoding Methods and Population Coding Across Thalamo-Cortical Head Direction Cells

The retrosplenial-parietal network and reference frame coordination for spatial navigation

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