Retrosplenial cortex has a time-dependent role in memory for visual stimuli.

Abstract

Although the retrosplenial cortex (RSC) is critically involved in spatial learning and memory, it appears to have more selective contributions to learning and memory for discrete cues. For example, damage to the RSC does not impair Pavlovian delay fear conditioning to a discrete auditory cue (e.g., tone), when RSC manipulation occurs just prior to, or shortly after, conditioning. In contrast, when lesions of the RSC occur following a substantial retention interval (e.g., 28 days), the RSC is necessary for retrieval of fear to the tone. Thus, the RSC makes time-dependent contributions to memory retrieval for discrete auditory cues. The purpose of the current experiment was to assess if the time-dependent involvement of the RSC in cue-specific fear memory extended to cues of other sensory modalities. Rats firsts underwent fear conditioning to a visual stimulus, and lesions of the RSC subsequently occurred 1 or 28 days later. Lesions of the RSC impaired fear expression when made 28 days after conditioning, but not when made 1 day following conditioning. Coupled with previous findings, the current results suggest the RSC is necessary for retrieval of remotely acquired cued fear memories across multiple modalities. (PsycINFO Database Record (c) 2018 APA, all rights reserved).

Deconstruction of the retrosplenial granular cortex for social behavior in the mouse model of fragile X syndrome

“…1F, G). Previous studies improved that the retrosplenial granular cortex (RSG) has dense connections with social-related brain regions (Vogt, 2019a) and integrates different kinds of sensory information, including auditory, visual and olfactory (Jiang et al, 2018;Todd et al, 2016). These results raise our hypothesis that RSG may regulate social behavior.…”

“…Anatomically, the retrosplenial cortex(RSC) reciprocally connected with many brain regions, including the hippocampus, thalamus, visual cortex, auditory cortex, motor cortex, and prefrontal cortex (Jiang et al, 2018;Todd et al, 2016). Most of them are key brain regions for social behavior, which is indicated by RSC's function, such as spatial navigation (11), emotion, learning and memory, and high cognitive functions: imagination.…”

When is the rat retrosplenial cortex required for stimulus integration?

“…For example, the retrosplenial cortex receives visual information directly from the geniculostriate and tecto-cortical visual systems and shares reciprocal connections with the parietal and parahippocampal cortices ( Van Groen & Wyss, 1990 , 1992a , 1992b ; Van Groen & Wyss, 2003 ). Indeed, research has shown that the rat retrosplenial cortex contributes to learning about stimuli that are not explicitly spatial ( Bussey, Muir, Everitt, & Robbins, 1996 ; Hindley, Nelson, Aggleton, & Vann, 2014 ; Jiang, DeAngeli, Bucci, & Todd, 2018 ; Keene & Bucci, 2008a , 2008b ; Kwapis, Jarome, Lee, & Helmstetter, 2015 ; Miller et al, 2014 ; Nelson, Hindley, Haddon, Vann, & Aggleton, 2014 ; Robinson, Keene, Iaccarino, Duan, & Bucci, 2011 ; Robinson et al, 2014 ; Smith, Freeman, Nicholson, & Gabriel, 2002 ; Smith, Miller, & Vedder, 2018 ).…”

Reward-associated configural cues elicit theta oscillations of rat retrosplenial neurons phase-locked to LFP theta cycles

“…Recent behavioral studies reported that the RSC is also implicated in storing and expression or retrieval of remote memory of nonspatial cues associated with reinforcement (Todd et al, 2016; Jiang et al, 2018; Fournier et al, 2019a). Theta oscillation is implicated in neurophysiological mechanisms for retrieval of remote memory: it reflects memory search and information transfer between the hippocampal formation and the cortical areas such as the RSC (Hasselmo, 2002; Fell and Axmacher, 2011; Burke et al, 2014).…”