2017
DOI: 10.1534/g3.117.040907
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Retrotransposons Are the Major Contributors to the Expansion of theDrosophila ananassaeMuller F Element

Abstract: The discordance between genome size and the complexity of eukaryotes can partly be attributed to differences in repeat density. The Muller F element (∼5.2 Mb) is the smallest chromosome in Drosophila melanogaster, but it is substantially larger (>18.7 Mb) in D. ananassae. To identify the major contributors to the expansion of the F element and to assess their impact, we improved the genome sequence and annotated the genes in a 1.4-Mb region of the D. ananassae F element, and a 1.7-Mb region from the D element … Show more

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Cited by 24 publications
(40 citation statements)
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“…We did not generalize our findings to the whole F element. Hence, we agree with Dunning Hotopp and Klasson that the results reported in Leung et al (2017) do not preclude the possibility that LGT from wAna is a contributor to the expansion of the D. ananassae F element in its entirety; specifically, LGT could be contributing to an expansion of the pericentric heterochromatin regions of the F element, as reported in Klasson et al (2014) .…”
supporting
confidence: 92%
See 1 more Smart Citation
“…We did not generalize our findings to the whole F element. Hence, we agree with Dunning Hotopp and Klasson that the results reported in Leung et al (2017) do not preclude the possibility that LGT from wAna is a contributor to the expansion of the D. ananassae F element in its entirety; specifically, LGT could be contributing to an expansion of the pericentric heterochromatin regions of the F element, as reported in Klasson et al (2014) .…”
supporting
confidence: 92%
“…In Leung et al (2017) , we provide evidence that Drosophila transposons have been major contributors to the expansion of the Drosophila ananassae fourth chromosome (Muller F element) arms. Dunning Hotopp and Klasson agree with this finding, but they take exception to our second conclusion, that lateral gene transfer (LGT) from the Wolbachia endosymbiont of D. ananassae ( wAna ) had only a minor role in the expansion of the D. ananassae fourth chromosome arms.…”
mentioning
confidence: 99%
“…While the dot chromosome is approximately 5 Mb long in D. melanogaster, it has expanded to over 18 Mb in Drosophila ananassae because of the massive accumulation of retroposons. 134 By contrast, the dot chromosome of Drosophila willistoni has fused to an autosome and evolved a comparable level of recombination rate and codon usage as that of euchromatic autosomes, suggesting a possible transition from a heterochromatic ancestor to euchromatin. 135 A parallel case is the fusion between the ancestral Y chromosome shared by all Drosophila species and the dot chromosome in Drosophila pseudoobscura, 133,136 with reduction in the size of intron and intergenic regions and some evidence of selective sweep on the Y chromosome after its transition to an autosome.…”
Section: Evolution Of Heterochromatin and Its Associated Proteinsmentioning
confidence: 99%
“…GEP faculty have worked collaboratively to generate and maintain curricula to introduce students to the appropriate computer-based tools and to the scientific questions under study [8,20]; all such materials are available on the GEP website under a "creative commons" license. Students who contribute documented gene models, and participate in reading and critiquing the final manuscript, are co-authors on the resulting scientific publication (e.g., [22], [23]). G-OnRamp was conceived by the GEP as a component of the technical infrastructure, simplifying the process of generating genome browsers.…”
Section: Fig 1 Overview Of the Genomics Education Partnershipmentioning
confidence: 99%