1989
DOI: 10.1002/ijc.2910430627
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Retrovirally induced murine B‐cell tumors rarely show proviral integration in sites common in T‐cell tumors

Abstract: The molecular etiology of retrovirally induced T-cell tumors has been shown in many cases to involve proviral integration near a cellular oncogene, c-myc, N-myc, Pim-1 and pvt-1 being frequent targets for insertional activation. Murine B-cell tumors induced by infection with murine leukemia virus have been studied for rearrangements in these and other loci. In contrast to the T-cell lymphomas, tumors of the B-cell lineage, either early B-cell tumors induced in nude mice or late B-cell tumors in immunocompetent… Show more

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Cited by 8 publications
(2 citation statements)
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“…21,22) In mouse spontaneous lymphomas, however, a provirus insertion into cmyc is frequently found in T-cell lymphomas 23,24) but relatively rarely in B-cell lymphomas 25) except for those in some AKXD recombinant inbred strains, 26) Cdkn2a-targeted C57BL mice injected with Moloney MuLV 27) and athymic mice infected with MuLV. 28) The prevalence of pre-B lymphomas in SL/Kh mice may be explained by their host genetic predisposition. The SL/Kh mice show transient expansion of pre-B cells in bone marrow at 3-6 weeks of age in advance of lymphoma development.…”
Section: Discussionmentioning
confidence: 99%
“…21,22) In mouse spontaneous lymphomas, however, a provirus insertion into cmyc is frequently found in T-cell lymphomas 23,24) but relatively rarely in B-cell lymphomas 25) except for those in some AKXD recombinant inbred strains, 26) Cdkn2a-targeted C57BL mice injected with Moloney MuLV 27) and athymic mice infected with MuLV. 28) The prevalence of pre-B lymphomas in SL/Kh mice may be explained by their host genetic predisposition. The SL/Kh mice show transient expansion of pre-B cells in bone marrow at 3-6 weeks of age in advance of lymphoma development.…”
Section: Discussionmentioning
confidence: 99%
“…No consistent chromosomal anomaly was detected in the murine B-cell lymphomas, although some structural aberrations were found more than once. Molecular analyses of a large series of B-cell lymphomas, including the karyotyped lymphomas described here, are documented in the companion paper (Matthews et al, 1989).…”
mentioning
confidence: 99%