Return of Vision in Transplanted Adult Salamander Eyes After Seven Days of Refrigeration

Stone, L. S.

doi:10.1001/archopht.1946.00890200140006

Cited by 6 publications

(3 citation statements)

References 6 publications

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“…2,[11][12][13][14][15][16][17][18][19][20][21][22][23] The remaining 19 utilized cold-blooded species. [3][4][5][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] After data extraction, a total of 1998 eyes were included, 1831 of which belonged to nonmammalian organisms and 167 to mammals, including 13 human cadavers and two living humans.…”

Section: Resultsmentioning

confidence: 99%

“…2,11–23 The remaining 19 utilized cold-blooded species. 3–5,24–39 After data extraction, a total of 1998 eyes were included, 1831 of which belonged to nonmammalian organisms and 167 to mammals, including 13 human cadavers and two living humans.…”

Section: Resultsmentioning

confidence: 99%

“…In several of these cases, the ocular allograft not only survived but restored vision as well. [3][4][5] With this, WET was again pursued on a human in 1969. 6 However, after the failure of this attempt, the medical community condemned the operation and the National Eye Institute advised against further investigations into the procedure.…”

Section: Introductionmentioning

confidence: 99%

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Technical Feasibility of Whole-eye Vascular Composite Allotransplantation: A Systematic Review

Laspro

Chaya

Brydges

et al. 2023

Plastic and Reconstructive Surgery - Global Open

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Background: There are over 43 million individuals in the world who are blind. As retinal ganglion cells are incapable of regeneration, treatment modalities for this condition are limited. Since first incepted in 1885, whole-eye transplantation (WET) has been proposed as the ultimate cure for blindness. As the field evolves, different aspects of the surgery have been individually explored, including allograft viability, retinal survival, and optic nerve regeneration. Due to the paucity in the WET literature, we aimed to systematically review proposed WET surgical techniques to assess surgical feasibility. Additionally, we hope to identify barriers to future clinical application and potential ethical concerns that could be raised with surgery. Methods: We conducted a systematic review of PubMed, Embase, Cochrane Library, and Scopus from inception to June 10, 2022, to identify articles pertaining to WET. Data collection included model organisms studied, surgical techniques utilized, and postoperative functional outcomes. Results: Our results yielded 33 articles, including 14 mammalian and 19 cold-blooded models. In studies performing microvascular anastomosis in mammals, 96% of allografts survived after surgery. With nervous coaptation, 82.9% of retinas had positive electroretinogram signals after surgery, indicating functional retinal cells after transplantation. Results on optic nerve function were inconclusive. Ocular-motor functionality was rarely addressed. Conclusions: Regarding allograft survival, WET appears feasible with no complications to the recipient recorded in previous literature. Functional restoration is potentially achievable with a demonstrated positive retinal survival in live models. Nevertheless, the potential of optic nerve regeneration remains undetermined.

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