In investing, what is comfortable is rarely profitable.-Robert Arnott Stroke is one of the leading causes of mortality and morbidity worldwide, leaving approximately one in four stroke survivors with significant disability. 1,2 In addition, stroke care is costly, with Canada alone spending approximately 3.6 billion dollars per year in stroke care. 3 These costs include both direct costs (i.e., hospital beds, hospital personnel and time, diagnostic imaging, surgical interventions, prescription medications, and physician costs) and indirect costs (i.e., out-of-pocket expenses for rehabilitation, loss of productivity, and informal caregiving). 4 Use of catheter-based endovascular thrombectomy (EVT) in eligible patients has been associated with a significant reduction in the disability and mortality associated with ischemic stroke. 3 However, EVT is only available for patients with an ischemic stroke due to a large-vessel arterial occlusion, approximately 25-46% of all acute ischemic stroke patients, 5 and of these, only few meet the inclusion criteria for EVT based on severity of symptoms and brain imaging. Further, it has additional costs associated with inter-hospital transfers; procedural and post-procedural care; and personnel costs, and so, it is only available at select few centers. 6 Therefore, at a population level, investing in EVT programs that benefit only a selected few has been an area of considerable debate for policy makers and health economists.In this issue of the Journal, Thanh et al. evaluate if investments in provincial EVT programs can help save money from a provincial perspective. 7 They examined the cost benefit of a provincial strategy, Endovascular Reperfusion Alberta (ERA) project, that aimed to improve access to EVT in Alberta. This provincially funded strategy included investments of $2.04 million and $3.73 million in the years 2018 and 2019, respectively, in the following areas: revision of emergency medical services triage and transport pathways, inter-hospital referrals, establishment of imaging in remote stroke centers, and improvement in processes to reduce treatment times. Subsequently, 172 and 218 more people received EVT in 2018 and 2019, respectively. To evaluate the savings that may have occurred from increasing access to EVT, the authors used health service utilization data and the associated direct costs, obtained from standardized provincial health care cost data, of 99 patients (52 of whom received EVT)