Sustainable construction requires high-strength cement materials that additives with silica content could provide the requirements as well. In this study, the effect of the micro and nano-size of silica on the compressive strength of cement paste using different mathematical approaches is investigated. This study compares the strength of preferentially replaced cement pastes with microsilica (MS) and nanosilica (NS) incorporation by proposing several mathematical models. In this study, 205 data were extracted from the literature and analyzed. The modeling processes considered the most significant variables as input variables that influence the compression strength, such as curing time, which ranged between 3 and 90 days, the water-cement ratio, which varied between 0.4 and 0.85, and NS ranged between 0 and 15%. MS ranged between 0 and 40% based on the weight of cement. In this process, the compressive strength of cement paste modified with NS and MS was modeled using four different models, including the Linear Regression Model (LR), Nonlinear Model (NLR), Multi-Logistic Regression Model (MLR), and artificial neural network (ANN). The efficiency of the suggested models was evaluated using different statistical assessments, such as the Root Mean Squared Error (RMES), the Mean Absolute Error (MAE), Scatter Index (SI), Objective value (OBJ), and coefficient of determination (R2). The findings revealed that the ANN model conducted better performance for predicting compressive strength for cement paste than the other models based on the statistical assessment. In addition, based on the statistical assessment of the sensitivity of parameters, NS had more of an effect on the compressive strength of cement paste, with 6.3% more than MS.