Revamping Mosquito-borne Disease Control to Tackle Future Threats

Fernandes, Jill N.; Moise, Imelda K.; Maranto, Gina; Beier, John C.

doi:10.1016/j.pt.2018.01.005

Cited by 78 publications

(53 citation statements)

References 43 publications

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“…Although arboviruses dispersal 7 is partially conditioned by the environmental constraints that limit the distribution of its main 8 vectors, outbreaks of diseases such as, yellow fever, chikungunya and Zika have been reported all 9 over the world (6)(7)(8)(9)(10). The severity of Zika fetal malformations during 2015/2016 epidemics turn 10 it a public health emergency of international concern according to World Health Organization 11 (11). The lack of effective approved vaccines for some of these infections and the increase of 12 insecticide resistance in its most competent vectors, impose an urgent need for innovative 13 effective strategies to minimize these diseases (12) (13).…”

Section: Author Summarymentioning

confidence: 99%

“…A total of 195/82.3% research articles, out of the 237 with efficacy outcomes, presented results 23 regarding the efficacy of Wolbachia and other symbiont-based insect modifications (111/56.9% 24 reported effective outcomes, 145/74.4% reported ineffective outcomes, nTotal=195). One 25 publication reported the efficacy of other symbiont-based insect modification strategy (a Sodalis 26 modified by paratrangenesis) (2), and two publications referred to computational studies using 27 archetypal modeled endosymbionts (10), (11). Efficacy results covered all the topics 28 lead to an increase of the insect vectorial capacity and consequently to an increase on disease 27 transmission, they constitute reversal outcomes.…”

Section: Wolbachia and Other Symbiont-based Modification Strategies (mentioning

confidence: 99%

“…suggested the need to release prohibitively large number of insects (100-102). To overcome that, 7 two solutions were reported: releases in a ratio of 95% male mosquitoes (requiring a mass rear 8 capacity) (11) or the introduction of insecticide resistance genes along with Wolbachia in the host 9…”

Section:  Release 29mentioning

confidence: 99%

“…No publications described the impact of Wolbachia-based modified insects on human disease 15 incidence. However, several computational modelling studies estimated a successful 16 epidemiological impact after the release of Wolbachia-insects (96), (11), specifically using wMel- and temperature). However, Wolbachia density in Ae.…”

Section:  Epidemiology 14mentioning

confidence: 99%

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What is known about modified insects for disease prevention?: a systematic review

Nazareth

Craveiro

Moutinho

et al. 2018

Preprint

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2The modification and release of insects to suppress or replace natural insect vectors constitutes 3 a promising tool for vector control and disease prevention, facing the unprecedented global 4 emergence of vector-borne diseases. Little is known regarding these innovative modification 5 strategies and available evidence is not standardized turning it difficult to reflect on their actual 6 efficacy and eventual effects. 7This work conducted a systematic review, gathering and analyzing research articles from PubMed 8 and Biblioteca Virtual em Saúde databases whose results directly report efficacy and effects of 9 the use of modified insects for disease prevention until 2016. Within more than 1500 publications 10 that were screened a total of 349 where analyzed. 11A total of 12/3.4% reported field-based evidence, and 41/11.7% covered modification stretagies' 12 efficacy after insects' release, their epidemiology impact or its long-term efficacy. Examples of 13 successful results were the replacement of natural field populations by wolbachia-infected 14 mosquitoes in 5 weeks, and the elimination of a population in laboratory cages after transgenic 15 mosquitoes release over 10-20 weeks. Variability in the effective results were described 16 (90/25.7%) questioning its reproducibility in different settings. We also found 38/10.9% 17 publications reporting reversal outcomes, such as an increase of vector population after release. 18Ecological effects such as horizontal transfer events to non-target species (54/15.5%), and 19 wolbachia-induced worsening pathogenesis on mammal filarial diseases (10/2.9%) were also 20 reported. 21Present work revealed promising outcomes of both suppressing and replacing approaches. 22However, it also revealed a need of field-based evidence mainly regarding epidemiologic and 23 long-term impact of insect modification strategies. It pointed out some eventual irreversible and 24 important effects that must not be ignored when considering open-field releases, and that may 25 constitute constraints to generate the missing field evidence. Moreover, the level of variability of 26 existing evidence suggests the need of local/specific evidence in each setting of an eventual 27 release. 28 29 30 31 32 33 34 35

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Section: Author Summarymentioning

confidence: 99%

Section: Wolbachia and Other Symbiont-based Modification Strategies (mentioning

confidence: 99%

Section:  Release 29mentioning

confidence: 99%

Section:  Epidemiology 14mentioning

confidence: 99%

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What is known about modified insects for disease prevention?: a systematic review

Nazareth

Craveiro

Moutinho

et al. 2018

Preprint

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“…The success of managing emerging and resurging mosquito-borne diseases relies on designing effective integrated vector management (IVM) tools, which include active vector monitoring (Fernandes et al 2018). The effectiveness and reliability of pan-regional systems for vector monitoring requires the development of homogeneous methodologies.…”

Section: Introductionmentioning

confidence: 99%

A litmus test for harmonized mosquito monitoring across Europe and Africa

Graziosi

Aranda

Balestrino

et al. 2020

Preprint

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The accelerating rate of outbreaks from mosquito borne diseases are urging the development of updated and effective tools for the surveillance of insect populations and their larval habitats. Harmonized field protocols help to build a comprehensive picture on species-specific vector ecology and generate important knowledge for implementing coordinated mosquito surveillance programs at regional scales and across continents. In this study, we test the efficiency and potential barriers of available harmonized protocols from earlier EU project VectorNet. As a kind of litmus test for such protocols, we specifically aim to capture the ecoregional variation of breeding site characteristics and population density of five mosquito vectors in Europe and Africa. As expected, the five species considered show different aquatic habitat preferences. Culex pipiens, Aedes albopictus in Europe and Ae. aegypti in Africa select breeding habitats within specific volume classes, while Anopheles gambiae and An. coluzzii may select breeding habitats based on seasonal availability. Population densities in aquatic habitats greatly varied across species and countries, but larval production sites of Ae. albopictus generate populations with higher ratio of pupae compared to the other species. This result underlines the fundamental ecological difference between the selected vector species disregarding of the ecoregion. Mean water temperatures had limited variation across species and higher among countries. Understanding the ecology of native and non-native mosquito vectors is key in evaluating transmission risks for diseases such as West Nile, chikungunya and dengue fevers, zika and malaria. The available harmonized field protocols are a valuable tool for achieving homogeneous mosquito surveillance in Europe and Africa.

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“They Say My Baby’s Head Is Too Small”

Brown

Morrow

2019

Bioethics, Public Health, and the Social Sciences for the Medical Professions

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Revamping Mosquito-borne Disease Control to Tackle Future Threats

Cited by 78 publications

References 43 publications

What is known about modified insects for disease prevention?: a systematic review

What is known about modified insects for disease prevention?: a systematic review

A litmus test for harmonized mosquito monitoring across Europe and Africa

“They Say My Baby’s Head Is Too Small”

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