Revascularization of an immature tooth with apical periodontitis using a single visit protocol: a case report

McCabe, P.

doi:10.1111/iej.12344

Cited by 53 publications

(86 citation statements)

References 49 publications

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“…Previous studies have also suggested limited residual antibacterial properties of NaOCl (29,34). Few endodontic regeneration case reports have demonstrated successful root canal disinfection using irrigation solutions without supplementary inter-appointment medicaments (5,6). However, the use of antibiotic intra-canal medicaments such as TAP in addition to irrigation solutions can be extremely helpful when an extended residual antibacterial effect is required (10).…”

Section: A3mentioning

confidence: 99%

“…Numerous studies have reported the success of this technique with regard to resolution of infection and continuous development of the immature roots (3,4). Root canal disinfection is imperative for successful endodontic regeneration procedures, and various antimicrobials have been used for this, including irrigation solutions such as sodium hypochlorite (NaOCl) (5) and chlorohexidine (6), inter-appointment medicaments such as calcium hydroxide (7), or various antibiotic mixtures (3). A recent systemic review found that 80% of clinical endodontic regeneration studies and case reports used antibiotic combinations as intracanal medicaments (8).…”

Section: Introductionmentioning

confidence: 99%

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Direct and indirect antibacterial effects of various concentrations of triple antibiotic pastes loaded in a methylcellulose system

et al. 2016

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We investigated the direct and indirect(residual) antibacterial effects of various concentrations of triple antibiotic paste (TAP) loaded into a methylcellulose system. Enterococcus faecalis (E. faecalis) was grown on sterilized dentin blocks (n = 60) and treated with clinically used TAP (1,000 mg/ mL), low concentrations of methylcellulose-based TAP (100, 10, and 1 mg/mL), placebo paste, or 1.5% NaOCl (n = 10). The pastes were then removed, and biofilm disruption assays were performed. Additional dentin blocks (n = 120) were pretreated with the same experimental groups (n = 20). The pastes were rinsed off, and the samples were immersed independently in phosphate-buffered saline for 2 and 4 weeks (n = 10). E. faecalis was then grown on the dentin blocks, and biofilm disruption assays were performed. Fisher's Exact and Wilcoxon rank sum tests were used for statistical analyses. With regard to direct antibacterial effects, all treatment groups demonstrated complete eradication of biofilms in comparison to placebo paste, while 10 mg/mL of TAP or higher provided substantial residual antibacterial effects. However, dentin treated with 1 mg/mL of TAP or 1.5% NaOCl did not provide substantial residual antibacterial effects. Dentin pretreated with 10 mg/mL of TAP or higher exhibited extended residual antibacterial effects and can thus be used during endodontic regeneration. (J Oral Sci 58, 575-582, 2016)

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Section: A3mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Direct and indirect antibacterial effects of various concentrations of triple antibiotic pastes loaded in a methylcellulose system

et al. 2016

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“…Because of it excellent sealing properties and biocompatibility, mineral trioxide aggregate (MTA) has been the material of choice for covering the blood clot [6,9,17,18]. However, placing MTA over a soft blood clot can be a formidible task; MTA may collapse into the newly-formed clot during condensation [19].…”

Section: Introductionmentioning

confidence: 99%

Cytotoxicity and osteogenic potential of silicate calcium cements as potential protective materials for pulpal revascularization

et al. 2015

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Objectives In pulpal revascularization, a protective material is placed coronal to the blood clot to prevent recontamination and to facilitate osteogenic differentiation of mesenchynal stem cells to produce new dental tissues. Although mineral trioxide aggregate (MTA) has been the material of choice for clot protection, it is easily displaced into the clot during condensation. The present study evaluated the effects of recently-introduced calcium silicate cements (Biodentine and TheraCal LC) on the viability and osteogenic differentiation of human dental pulp stem cells (hDPSCs) by comparing with MTA Angelus. Methods Cell viability was assessed using XTT assay and flow cytometry. The osteogenic potential of hDPSCs exposed to calcium silicate cements was examined using qRT-PCR for osteogeic gene expressions, alkaline phosphatase enzyme activity, Alizarin red S staining and transmission electron microscopy of extracellular calcium deposits. Parametric statistical methods were employed for analyses of significant difference among groups, with α=0.05. Results The cytotoxic effects of Biodentine and TheraCal LC on hDPSCs were time- and concentration-dependent. Osteogenic differentiation of hDPSCs was enhanced after exposure to Biodentine that was depleted of its cytotoxic components. This effect was less readily observed in hDPSCs exposed to TheraCal LC, although both cements supported extracelluar mineralization better than the positive control (zinc oxide-eugenol–based cement). Significance A favorable tissue response is anticipated to occur with the use of Biodentine as a blood clot-protecting material for pulpal revascularizaiton. Further investigations with the use of in vivo animal models are required to validate the potential adverse biological effects of TheraCal LC on hDPSCs.

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“…MTA needs to be placed at the level of the cervical constriction or even a little more coronally (27). A more coronal placement of MTA will potentially achieve hard tissue formation in the critical cervical area of the tooth which is where catastrophic fractures appear to occur (28).…”

mentioning

confidence: 99%

Evaluation of Cervical Crown/Root Fracture Following PRF Revascularization Versus Root Canal Treatment of Non-Vital Anterior Permanent Teeth With Closed Apex (Randomized Clinical Trial).

Nageh¹,

Ezzat²,

Ahmed³

2017

IJAR

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Revascularization of an immature tooth with apical periodontitis using a single visit protocol: a case report

Abstract: Disinfection with 5% sodium hypochlorite followed by the induction of a blood clot into the root canal space may be sufficient to promote revascularization in certain circumstances. A single visit revascularization procedure is a potential treatment option.

Cited by 53 publications

References 49 publications

Direct and indirect antibacterial effects of various concentrations of triple antibiotic pastes loaded in a methylcellulose system

Direct and indirect antibacterial effects of various concentrations of triple antibiotic pastes loaded in a methylcellulose system

Cytotoxicity and osteogenic potential of silicate calcium cements as potential protective materials for pulpal revascularization

Evaluation of Cervical Crown/Root Fracture Following PRF Revascularization Versus Root Canal Treatment of Non-Vital Anterior Permanent Teeth With Closed Apex (Randomized Clinical Trial).

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