Revealing a role of brainstem monoaminergic nuclei on the pronociceptive effect of sleep restriction

Sardi, Natalia F.; Pescador, Ana C.; Torres-Chavez, Karla E.; Fischer, Luana

doi:10.1016/j.neuropharm.2024.110055

Neuropharmacology

2024

DOI: 10.1016/j.neuropharm.2024.110055

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Revealing a role of brainstem monoaminergic nuclei on the pronociceptive effect of sleep restriction

Natalia F. Sardi,

Ana C. Pescador,

Karla E. Torres-Chavez

et al.

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2024

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Cited by 2 publications

References 47 publications

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Sleep disorders and orofacial pain: insights for dental practice

McCloy,

Herrero Babiloni,

Sessle

2024

Australian Dental Journal

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In dental sleep medicine several sleep disorders commonly coexist with pain, contributing to complex clinical presentations which might affect the provision of appropriate and timely treatment. There are associations between sleep disorders and pain in general, as well as with specific orofacial pain conditions. As many as five of six patients with orofacial pain can present with sleep problems. The comorbidity of orofacial pain and sleep disorders overlays a complex web of altered neurobiological mechanisms that predispose to the chronification of orofacial pain. This review discusses the relationship between orofacial pain and sleep disorders and highlights their interactions and the neurobiological mechanisms underlying those relationships.

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Sleep disorders and orofacial pain: insights for dental practice

McCloy,

Herrero Babiloni,

Sessle

2024

Australian Dental Journal

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The Locus Coeruleus in Chronic Pain

España,

Yasoda-Mohan,

Vanneste

2024

IJMS

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Pain perception is the consequence of a complex interplay between activation and inhibition. Noradrenergic pain modulation inhibits nociceptive transmission and pain perception. The main source of norepinephrine (NE) in the central nervous system is the Locus Coeruleus (LC), a small but complex cluster of cells in the pons. The aim of this study is to review the literature on the LC-NE inhibitory system, its influence on chronic pain pathways and its frequent comorbidities. The literature research showed that pain perception is the consequence of nociceptive and environmental processing and is modulated by the LC-NE system. If perpetuated in time, nociceptive inputs can generate neuroplastic changes in the central nervous system that reduce the inhibitory effects of the LC-NE complex and facilitate the development of chronic pain and frequent comorbidities, such as anxiety, depression or sleeping disturbances. The exact mechanisms involved in the LC functional shift remain unknown, but there is some evidence that they occur through plastic changes in the medial and lateral pathways and their brain projections. Additionally, there are other influencing factors, like developmental issues, neuroinflammatory glial changes, NE receptor affinity and changes in LC neuronal firing rates.

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Revealing a role of brainstem monoaminergic nuclei on the pronociceptive effect of sleep restriction

Cited by 2 publications

References 47 publications

Sleep disorders and orofacial pain: insights for dental practice

Sleep disorders and orofacial pain: insights for dental practice

The Locus Coeruleus in Chronic Pain

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