Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

Shlapakova, Lada E.; Surmeneva, Maria A.; Kholkin, Andrei L.; Surmenev, Roman A.

doi:10.1016/j.mtbio.2024.100950

Cited by 17 publications

(1 citation statement)

References 152 publications

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“…In addition, materials such as poly (l-lactic acid), poly (lactic-co-glycolic acid), polyhydroxybutyrate and polyamides (Nylons, peptides, etc.) have been used as options for the preparation of piezoelectric tissue engineering scaffolds because of their wide availability, slow uptake, non-toxic by-products and excellent degradation properties ( Shlapakova et al, 2024 ). These materials have to be widely used in tissues such as bone, cartilage, and nerve, however, no investigator has yet used them for IVD regeneration.…”

Section: Piezoelectric Biomaterialsmentioning

confidence: 99%

Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation?

Huang,

Wang,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

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Intervertebral disc degeneration (IDD) due to multiple causes is one of the major causes of low back pain (LBP). A variety of traditional treatments and biologic therapies are currently used to delay or even reverse IDD; however, these treatments still have some limitations. Finding safer and more effective treatments is urgent for LBP patients. With increasing reports it has been found that the intervertebral disc (IVD) can convert pressure loads from the spine into electrical stimulation in a variety of ways, and that this electrical stimulation is of great importance in modulating cell behavior, the immune microenvironment and promoting tissue repair. However, when intervertebral disc degeneration occurs, the normal structures within the IVD are destroyed. This eventually leads to a weakening or loss of self-powered. Currently various piezoelectric materials with unique crystal structures can mimic the piezoelectric effect of normal tissues. Based on this, tissue-engineered scaffolds prepared using piezoelectric materials have been widely used for regenerative repair of various types of tissues, however, there are no reports of their use for the treatment of IDD. For this reason, we propose to utilize tissue-engineered scaffolds prepared from piezoelectric biomaterials with excellent biocompatibility and self-powered properties to be implanted into degenerated IVD to help restore cell type and number, restore extracellular matrix, and modulate immune responses. It provides a feasible and novel therapeutic approach for the clinical treatment of IDD.

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Section: Piezoelectric Biomaterialsmentioning

confidence: 99%

Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation?

Huang,

Wang,

Liu

et al. 2024

Front. Bioeng. Biotechnol.

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3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review

Li,

Shan,

Chen

et al. 2024

Adv Materials Technologies

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Piezoelectric composites have received widespread attentions in the fields of biomedicine and in vitro wearable devices due to their ability to convert mechanical forces into charge signals. The preparation of piezoelectric composites with complex structures through 3D printing technology can not only effectively improve their piezoelectric output, but also enable their customized therapeutic applications. This paper first introduces the types of piezoelectric composites and reviews the 3D printing technology commonly used in their preparation, analyzing the advantages and disadvantages of each 3D printing technology. Then, the state‐of‐the‐art of the biomedical applications of piezoelectric composites, including drug sustained‐release, wound healing promotion, bone tissue cells growth promoting, neurorehabilitation stimulating, ultrasonic diagnosis, and in vivo biosensing and in vitro wearable sensing, are emphasized. Finally, the main factors affecting the applications of 3D printed piezoelectric composites are outlooked, and an in‐depth discussion on the challenges toward 3D printed piezoelectric composites are analyzed. This review is believed to provide some fundamental knowledge of 3D printed piezoelectric composites.

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Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth

Hassani,

Golshani,

Mehrabi

et al. 2024

Can J Chem Eng

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Nerve guidance conduits (NGCs) have been shown to be effective in promoting nerve regeneration in a variety of clinical applications, including nerve defects resulting from a trauma or surgery. By providing a conducive environment for nerve growth, NGCs can help to restore function in nerve‐damaged patients. Challenges include limited repair length, difficulty replicating natural nerve, and rapid substance degradation affecting neurotrophic factor delivery. Considering these issues with mass transfer and fluid structure interaction (FSI) emphasizes the need for enhancing nerve regeneration efficiency. To facilitate nerve growth and deliver appropriate amount of growth factors, these conduits need to be designed with specific topological, mechanical, and biological properties. Additionally, considerations must be given to functional mass transfer FSI design. An intelligent NGC design is proposed as an evaluation‐optimization and AI‐based method. It is found that design parameters significantly impact the physical properties being optimized, including hydraulic pressure, porosity, diffusivity, water absorption, and maximum stress. The mathematical surrogate model obtained from data‐based modelling is used for artificial intelligence (AI) optimization algorithms, differential evolution (DE), and non‐dominated sorting genetic algorithm II (NSGA‐II). It is revealed that both DE and NSGA algorithms generate nearly identical solutions, ensuring the robustness of ML optimization. Our results show that NGC with the thickness of 750 μm results in more than 170% augmentation of porosity. Moreover, at a constant ovality, increasing the channel thickness results in more than 39.2% augmentation of the maximum stress. The accurate forecasting of physical characteristics on NGC regarding nerve growth factors enables a hopeful outlook for the future clinical treatment of nerve injuries and advanced tissue engineering.

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Revealing an important role of piezoelectric polymers in nervous-tissue regeneration: A review

Cited by 17 publications

References 152 publications

Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation?

Can self-powered piezoelectric materials be used to treat disc degeneration by means of electrical stimulation?

3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review

Intelligent design of nerve guidance conduits: An artificial intelligence‐driven fluid structure interaction study on modelling and optimization of nerve growth

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