Revealing the antibacterial power of hydrogen-releasing PdH nanohydride against drug resistant Staphylococcus aureus: an in-depth mechanism study

Abstract

Hydrogen (H2) has been demonstrated to be highly effective in combating drug-resistant Staphylococcus aureus by breaking the redox homeostasis of bacterial metabolism and down-regulating expression of many drug-resistant genes like fmtA, gpsB, etc.

Copper peroxide nanodot-decorated gold nanostar/silica nanorod Janus nanostructure with NIR-II photothermal and acid-triggered hydroxyl radical generation properties for the effective treatment of wound infections

“…Bacterial membrane damage can also lead to the efflux of intracellular components, such as DNA, RNA, or other functional proteins, which can be quantified by measuring the optical density value at 260 nm wavelength (OD 260 ). 31,32 Consistent with the above results, MPTT and CDT alone did trigger the leakage of intracellular components, as the OD 260 values clearly increased in comparison with the control groups (Fig. 5C and E).…”

Poly(ionic liquid)-Flocculated Chlorella Loading Bactericidal and Antioxidant Hydrogel as a Biological Hydrogen Therapy for Diabetic Wound Dressing

“…coli after coculture for 4 h, respectively. The improved antimicrobial effect of HAP-Chl may be caused by the synergistic effect of H 2 produced by the flocculated Chlorella and PIL incorporated in the hydrogels. , To further confirm the antibacterial abilities of the hydrogels, a live/dead staining assay was further performed. Almost no red fluorescence signals were observed in HAMA or HA-Chl treated bacteria (Figure c), indicating their poor antibacterial ability.…”

Chemistry of Hydrogen Sulfide—Pathological and Physiological Functions in Mammalian Cells

“…Antibiotics such as quinolones, beta-lactams and aminoglycosides are more effective against bacterial pathogens in vitro and in mouse models when combined with small compounds that block a bacterial enzyme involved in the formation of hydrogen sulfide [126]. Therefore, it has been hypothesized that this messenger is a fundamental anti-antibiotic defense mechanism in bacteria [126,127]. In biofilms, persisting cells had significantly higher H 2 S content than active cells, supporting the notion that H 2 S is a critical component in bacterial biofilm formation [128].…”