2024
DOI: 10.3389/fcimb.2024.1452392
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Revealing the association between East Asian oral microbiome and colorectal cancer through Mendelian randomization and multi-omics analysis

Yuheng Gu,
Lai Jiang,
Min Shui
et al.

Abstract: BackgroundColorectal cancer (CRC) poses a global health threat, with the oral microbiome increasingly implicated in its pathogenesis. This study leverages Mendelian Randomization (MR) to explore causal links between oral microbiota and CRC using data from the China National GeneBank and Biobank Japan. By integrating multi-omics approaches, we aim to uncover mechanisms by which the microbiome influences cellular metabolism and cancer development.MethodsWe analyzed microbiome profiles from 2017 tongue and 1915 s… Show more

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