Revealing the clinical effect and biological mechanism of acupuncture in COPD: A review

Shi, Fangyuan; Cao, Jiaojiao; Zhou, Dan; Wang, Xue; Yang, Haitao; Liu, Tingting; Chen, Zhihan; Zeng, Jiaming; Du, Simin; Yang, Lin; Jia, Ruo; Zhang, Siqi; Zhang, Mingxing; Guo, Yi; Lin, Xiaowei

doi:10.1016/j.biopha.2023.115926

Cited by 1 publication

(1 citation statement)

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“…The high-altitude adaptation can lead to increased lung ventilation, which in turn leads to blood concentration [ 30 ]. At the same time, an increase in diffusion volume in COPD patients can also lead to an increase in blood viscosity [ 31 ]. Consequently, this may increase the risk of thromboembolism in patients with COPD, contributing to factors such as systemic inflammation, hypoxemia, oxidative stress, endothelial dysfunction, and a prothrombotic state [ 32 ].…”

Section: Discussionmentioning

confidence: 99%

Prevalence, risk factors, and clinical characteristics of pulmonary embolism in patients with acute exacerbation of COPD in Plateau regions: a prospective cohort study

Yang,

Tuo,

Shi

et al. 2024

BMC Pulm Med

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Background and objective To investigate pulmonary thromboembolism (PE) in acute exacerbation of chronic obstructive pulmonary disease (AE-COPD) patients in plateau regions, we performed a prospective cohort study to evaluate the prevalence, risk factors and clinical characteristics of PE in the cohort of hospitalized patients at high altitude. Methods We did a prospective study with a total of 636 AE-COPD patients in plateau regions. Demographic and clinical data, laboratory data, including ultrasound scans of the lower extremities and cardiac ultrasound, and computed tomographic pulmonary angiography (CTPA) variables were obtained, and comparisons were made between groups with and without PE. We also conducted logistic regression to explore the risk factors of PE. Results Of the 636 patients hospitalized with AE-COPD (age 67.0 ± 10.7 years, 445[70.0%] male), 188 patients developed PE (29.6% [95% CI: 26.0%, 33.1%]). Multivariable logistic regression showed that ethnic minorities, D-dimer > 1 mg/L, AST > 40 U/L, chest pain, cardiac insufficiency or respiratory failure, Padua score > 3, and DVT were associated with a higher probability of PE. Conclusions The prevalence of PE is high and those with a higher Padua score, the occurrence of deep venous thrombosis, higher neutrophil count, chest pain, cardiac insufficiency or respiratory failure, higher levels of AST, and a higher level of D-dimer had a higher risk of PE. The analysis of AE-COPD may help to provide more accurate screening for PE and improve clinical outcomes of patients with AE-COPD in plateau regions.

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Section: Discussionmentioning

confidence: 99%