2020
DOI: 10.33574/hjog.1979
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Revealing the enigma of coagulation in endometriosis: the risk of thrombosis and the role of antithrombotic treatment

Abstract: Endometriosis is a chronic inflammatory disease of women of reproductive age that is defined by the presence of ectopic endometrium. The pathophysiology of the disease is poorly understood, however platelet activation play a crucial role in initiation of inflammation and fibrinogenesis, which in term further activate the coagulation cascade. The relationship between inflammation and coagulation motivated researchers to study whether patients are in a hypercoagulable state and if endometriosis represent an inde… Show more

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Cited by 2 publications
(6 citation statements)
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“…Platelet activation and the coagulation cascade raise extreme concern that the risk of thromboembolism may be increased in patients with endometriosis. It appears that coagulation factors in peripheral blood and hypercoagulable status can be important in the progression of the disease [2] . This is the first study to evaluate the effects of PTX with MICT and HIIT, separately or in combination, on anti-inflammatory and anti-coagulation factors in endometriosis.…”
Section: Discussionmentioning
confidence: 99%
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“…Platelet activation and the coagulation cascade raise extreme concern that the risk of thromboembolism may be increased in patients with endometriosis. It appears that coagulation factors in peripheral blood and hypercoagulable status can be important in the progression of the disease [2] . This is the first study to evaluate the effects of PTX with MICT and HIIT, separately or in combination, on anti-inflammatory and anti-coagulation factors in endometriosis.…”
Section: Discussionmentioning
confidence: 99%
“… [1] Control: oral gavage of the vehicle (saline) for eight weeks; [2] MICT: executing MICT for 5 days a week; [3] Drug (D) group: gavage of PTX (100 mg/kg/d); [4] MICT+D: executing MICT 5 days a week and gavage of PTX (100 mg/kg/d); [5] HIIT: executing HIIT 5 days a week; [6] HIIT+D: executing HIIT 5 days a week and gavage of PTX (100 mg/kg/d).…”
Section: Methodsmentioning
confidence: 99%
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