Revealing the Impact of Gut Microbiota on Acne Through Mendelian Randomization Analysis

Ji, Xiaotian; Wu, Shuhui; Zhao, Dan; Bai, Qi; Wang, Yun; Gong, Ke; Zheng, Huie; Zhu, Mingfang

doi:10.2147/ccid.s451104

Cited by 3 publications

(1 citation statement)

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“…There are several instruments for measuring acne severity that are not interchangeable because they do not measure the same disease components [ 8 , 9 ]. Modern lifestyles involving exposure to skin care products, cosmetics, medications, and pollution induce changes in the skin microbiome [ 10 , 11 , 12 , 13 , 14 ]. Acne is a multifactorial disease that can be improved by daily use of appropriate skin care products.…”

Section: Discussionmentioning

confidence: 99%

Microbiome Modulation in Acne Patients and Clinical Correlations

Ionescu,

Tatu,

Busila

et al. 2024

Life

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Background: The imbalance of skin microbiota in acne can induce changes leading to induction or to aggravation of chronic inflammatory lesions; complex mechanisms are involved. Cutibacterium acnes (C. acnes) ribotypes RT4 and RT5 express more biofilm and are associated with inflammatory acne lesions. C. acnes RT6 is a non-acne ribotype, beneficial for the skin. Objectives: In an open clinical trial, acne adults were included and assessed clinically at baseline and at month 2 using the Investigator Global Assessment of Acne (IGA) score. A topical emulsion was applied twice daily for 2 months (M2) in each included patient. In the same series of acne patients, skin swab samples were collected from acne patients at baseline and M2 from lesional and non-lesional skin; skin swabs were collected for the metagenomic long-read analysis of microbiota. Materials and Methods: Acne patients with a gravity score IGA of >1<3 were included in this pilot study. An emulsion of O/W formulated with vegetal extract of Umbelliferae associated with a polysaccharide at 1% was applied twice daily for 2 months. At baseline and M2 clinical assessments were made; skin swab samples were also taken for microbiota analysis from lesional and non-lesional skin in each included patient. Extractions of genomic DNA (gDNA) from swab samples from baseline and from M2 were made, followed by full-length (V1–V9) amplification of the 16S rDNA and sequencing of amplicon libraries for strain-level bacterial community profiling. Results: In a series of 32 adult acne patients, the mean initial IGA scale was 3.1; at M2 the IGA scale was 1.5 (p < 0.001). The mean decrease in acne lesions was by 63%. Microbiome metagenomic long-read analysis in these series was mainly dominated by C. acnes followed by Staphylococcus epidermidis (S. epidermidis). The density of C. acnes ribotypes RT6 (non-acne strain) was increased at M2 compared to baseline and the density of ribotypes C. acnes RT1 to RT5 was decreased at M2, compared to baseline (p < 0.0001). S. epidermidis ribotypes (1 to 36) were non significantly increased at M2, compared to baseline (p < 0.1). Conclusions: In a series of 32 acne patients that applied an emulsion based on vegetal extract of Umbelliferae and a polysaccharide at 1% twice daily, a significant clinical improvement in IGA scale for acne lesions was seen at M2, compared to baseline (p < 0.0001). The clinical improvement was correlated with an improvement in skin microbiome at M2 compared to baseline, indicated by the increase in the relative abundance of non-acne strain of C. acnes ribotype 6 and of the decrease in the relative abundance of acne strains ribotypes C. acnes RT1 to RT5.

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Section: Discussionmentioning

confidence: 99%

Microbiome Modulation in Acne Patients and Clinical Correlations

Ionescu,

Tatu,

Busila

et al. 2024

Life

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The Causal Effect Between Human Microbiota and Scabies: A Study from the Genetic Perspective

Zheng,

Li,

Zhu

et al. 2024

CCID

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Background Previous studies have indicated that human flora may affect the development of scabies, however, no studies have proven a causal relationship between human flora and scabies, which would be detrimental to future in-depth studies on human flora and scabies. Methods Mendelian randomization (MR) was used to analyze the causal effect between human microbiota and scabies, with data on intestinal flora and skin flora from two large published studies and data on scabies from the FinnGen database. Five MR analysis methods were used to increase the reliability of the results, and sensitivity analyses were conducted to increase the robustness of the results. Results Our results suggest that 13 intestinal flora as well as 7 skin flora can have a causal effect on scabies. Conclusion Overall, our results demonstrate a causal relationship between intestinal and skin flora and scabies and are consistent with previous observational findings. This will contribute to the future development of probiotic agents for the prevention or treatment of scabies.

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Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions

Zou,

Gao

et al. 2024

Front. Cell. Infect. Microbiol.

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BackgroundPsoriasis is one of the most common autoimmune skin diseases. Increasing evidence shows that alterations in the diversity and function of microbiota can participate in the pathogenesis of psoriasis through various pathways and mechanisms.ObjectiveTo review the connection between microbial changes and psoriasis, how microbial-targeted therapy can be used to treat psoriasis, as well as the potential of prebiotics, probiotics, synbiotics, fecal microbiota transplantation, diet, and Traditional Chinese Medicine as supplementary and adjunctive therapies.MethodsLiterature related to the relationship between psoriasis and gut microbiota was searched in PubMed and CNKI.ResultsAdjunct therapies such as dietary interventions, traditional Chinese medicine, and probiotics can enhance gut microbiota abundance and diversity in patients with psoriasis. These therapies stimulate immune mediators including IL-23, IL-17, IL-22, and modulate gamma interferon (IFN-γ) along with the NF-kB pathway, thereby suppressing the release of pro-inflammatory cytokines and ameliorating systemic inflammatory conditions.ConclusionThis article discusses the direction of future research and clinical treatment of psoriasis from the perspective of intestinal microbiota and the mechanism of traditional Chinese medicine, so as to provide clinicians with more comprehensive diagnosis and treatment options and bring greater hope to patients with psoriasis.

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Revealing the Impact of Gut Microbiota on Acne Through Mendelian Randomization Analysis

Cited by 3 publications

References 46 publications

Microbiome Modulation in Acne Patients and Clinical Correlations

Microbiome Modulation in Acne Patients and Clinical Correlations

The Causal Effect Between Human Microbiota and Scabies: A Study from the Genetic Perspective

Gut microbiota and psoriasis: pathogenesis, targeted therapy, and future directions

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