Revealing the single-channel characteristics of OprD (OccAB1) porins from hospital strains of Acinetobacter baumannii

Ebrahimi, Aliakbar; Ergün, Tuğçe; İzgördü, Özge Kaygusuz; Darcan, Cihan; Avcı, Hüseyin; Öztürk, Şerife Barçın; Güner, Rahmet; Ghorbanpoor, Hamed; Güzel, Fatma Doğan

doi:10.1007/s00249-023-01651-2

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“…For example, OprD is a substrate-specific porin that facilitates the diffusion of basic amino acids, small peptides, and carbapenems (Trias and Nikaido 1990 ). Decreased expression of this porin was shown to be related to resistance to antibiotics in some pathogens including Acinetobacter baumannii and Pseudomonas aeroginosa (Strateva and Yordanov 2009 ; Ebrahimi et al 2023 ). OprD of these bacteria which have mutations in their DNA sequence had a unique porin diameter and decreased anion selectivity compared to the wild-type strain (Ebrahimi et al 2023 ).…”

Section: Introductionmentioning

confidence: 99%

“…Decreased expression of this porin was shown to be related to resistance to antibiotics in some pathogens including Acinetobacter baumannii and Pseudomonas aeroginosa (Strateva and Yordanov 2009 ; Ebrahimi et al 2023 ). OprD of these bacteria which have mutations in their DNA sequence had a unique porin diameter and decreased anion selectivity compared to the wild-type strain (Ebrahimi et al 2023 ). Efflux pumps are also found to be related to the multidrug resistance mechanisms of A. baumannii (Sharma et al 2023 ).…”

Section: Introductionmentioning

confidence: 99%

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Microbial membrane transport proteins and their biotechnological applications

Özkan,

Yılmaz,

Ergenekon

et al. 2024

World J Microbiol Biotechnol

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Because of the hydrophobic nature of the membrane lipid bilayer, the majority of the hydrophilic solutes require special transportation mechanisms for passing through the cell membrane. Integral membrane transport proteins (MTPs), which belong to the Major Intrinsic Protein Family, facilitate the transport of these solutes across cell membranes. MTPs including aquaporins and carrier proteins are transmembrane proteins spanning across the cell membrane. The easy handling of microorganisms enabled the discovery of a remarkable number of transport proteins specific to different substances. It has been realized that these transporters have very important roles in the survival of microorganisms, their pathogenesis, and antimicrobial resistance. Astonishing features related to the solute specificity of these proteins have led to the acceleration of the research on the discovery of their properties and the development of innovative products in which these unique properties are used or imitated. Studies on microbial MTPs range from the discovery and characterization of a novel transporter protein to the mining and screening of them in a large transporter library for particular functions, from simulations and modeling of specific transporters to the preparation of biomimetic synthetic materials for different purposes such as biosensors or filtration membranes. This review presents recent discoveries on microbial membrane transport proteins and focuses especially on formate nitrite transport proteins and aquaporins, and advances in their biotechnological applications.

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