Revealing the synergetic interaction between amino and carbonyl functional groups and their effect on the electronic and optical properties of carbon dots

Santika, Arum Sinda; Permatasari, Fitri Aulia; Umami, Reza; Muyassiroh, Diva Addini Maghribi; Irham, Muhammad Alief; Fitriani, Pipit; Iskandar, Ferry

doi:10.1039/d2cp03401h

Cited by 14 publications

(6 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The peak at 1628 cm –1 indicated that the C=O/C=C functional group involved in the conjugated double bond of carbon with the C-O/C-N at 1454 and 1363 cm –1 resulted in the fluorescence of CDs after lightening by the UV beam. 33 , 34 As reported in our previous work, these typical CDs plausibly consist of various C–N configurations, including Pyridinic-N, Pyrrolic-N, Graphitic-N, and Amino-N, on their surfaces. 35 Therefore, it is highly plausible that the as-prepared CDs are N-doped CDs rather than pristine CDs.…”

Section: Resultssupporting

confidence: 61%

In Vitro and Silico Studies on the N-Doped Carbon Dots Potential in ACE2 Expression Modulation

et al. 2023

Self Cite

View full text Add to dashboard Cite

The alteration of ACE2 expression level, which has been studied in many diseases, makes the topic of ACE2 inducer potential crucial to be explored. The ACE2 inducer could further be designed to control the ACE2 expression level, which is appropriate to a specific case. An in vitro study of well-characterized carbon dots (CDs), made from citric acid and urea, was performed to determine their ability to modulate the ACE2 receptor. Gene expression of ACE2 was quantified using concentrations adjusted for IC50 results from CDs viability assays in HEK 293 and A549 cell lines. RT-qPCR was used to assess the expression of the ACE2 gene and its induction effect in normal cell lines (HEK-293A). According to the results of the tests, ACE2 is expressed in HEK-293A cell lines, and diminazene aceturate can increase ACE2 expression. The effect of CDs on ACE2 gene expression was further examined on the cell lines that had previously been induced with diminazene aceturate, which resulted in upregulation of the ACE2 expression level. An in silico study has been done by using a molecular docking approach. The molecular docking results show that CDs can make strong interactions with ACE2 amino acid residues through hydrophobic interaction, π–π interaction, π-cation interaction, and ionic interaction.

show abstract

Section: Resultssupporting

confidence: 61%

In Vitro and Silico Studies on the N-Doped Carbon Dots Potential in ACE2 Expression Modulation

et al. 2023

Self Cite

View full text Add to dashboard Cite

show abstract

“…This result is based on a few studies using urea as a carbonyl and amino group precursor. Santika et al showed that carbonyl and amino groups provide the absorbance peak shifting farther than the other doping, which only had one of the groups . The carbonyl group was related to shifting under the empty molecular orbital, while the amino group donated their electron to the carbonyl system; therefore, it will meaningfully shift the absorbance peak to the farther wavelength.…”

Section: Resultsmentioning

confidence: 99%

Functionalized Phytochemicals-Embedded Carbon Dots Derived from Medicinal Plant for Bioimaging Application

Annisa,

Permatasari,

Iskandar

et al. 2023

ACS Appl. Bio Mater.

Self Cite

View full text Add to dashboard Cite

Precise visualization of biological processes necessitates reliable coloring technologies, and fluorescence imaging has emerged as a powerful method for capturing dynamic cellular events. Low emission intensity and solubility of intrinsic fluorescence are still challenging, hindering their application in the biomedical field. The nanostructurization and functionalization of the insoluble phytochemicals, such as chlorophyll and curcumin, into carbon dots (CDs) were conducted to address these challenges. Due to their unique fluorescence characteristics and biocompatibility, CDs derived from medicinal plants hold promise as bioimaging agents. Further, the nitrogen in situ functionalization of the as-synthesized CDs offered tunable optical properties and enhanced solubility. The surface modification aims to achieve a more positive zeta potential, facilitating penetration through biological membranes. This work provides valuable insights into utilizing functionalized phytochemical-embedded carbon dots for bioimaging applications. The doping of nitrogen by adding urea showed an alteration of surface charge, which is more positive based on zeta potential measurement. The more positive CD particles showed that Andrographis paniculata-urea-based CDs were the best particles to penetrate cells than others related to the alteration of the surface charge and the functional group of the CDs, with the optimum dose of 12.5 μg/mL for 3 h of treatment for bioimaging assay.

show abstract

“…Researchers have turned to carbon dots as potential alternatives to address this issue. Carbon dots (CDs), the newly discovered RTP materials, have recently gained much attention due to their facile preparation, low cost, good photostability, and low toxicity. − Various synthesis methods have been developed, including top-down and bottom-up methods, for CDs due to their outstanding properties. The microwave method has gained significant popularity in synthesizing and modifying CDs due to its capability to uniformly and rapidly penetrate and heat samples. − This feature enables shorter synthesis times, facilitating expedited advancements in material development.…”

Section: Introductionmentioning

confidence: 99%

Machine Learning-Guided Synthesis of Room-Temperature Phosphorescent Carbon Dots for Enhanced Phosphorescence Lifetime and Information Encryption

Muyassiroh,

Permatasari,

Hirano

et al. 2024

ACS Appl. Nano Mater.

Self Cite

View full text Add to dashboard Cite

Room-temperature phosphorescent (RTP) carbon dots (CDs) have been increasingly used in many applications, including anticounterfeiting and information encryption. However, synthesizing RTP CDs with a specific average lifetime of phosphorescence remains a formidable challenge. A breakthrough is needed in formulating the synthesis process to find a suitable synthesis formulation to produce CDs with an optimal lifetime of phosphorescence. Machine learning (ML) has recently been successfully used for guiding material synthesis and offering insight into the prediction, optimization, and acceleration of the CDs' synthesis process. A regression ML model on microwave-assisted CD synthesis is established to reveal the relationship between various synthesis parameters and enhance the average lifetime of phosphorescence of CDs in the solid-state phase. RTP CDs exhibit a blue emission when irradiating with UV and a green emission afterglow after the UV is turned off. These green emissions can last for 7 s, are easily observed by the naked eye, and show an ultralong phosphorescence lifetime of up to 1.6 s. Moreover, designed and guided by ML, this afterglow feature was explored to achieve multilevel anticounterfeiting and information encryption to encrypt and decrypt secret information in dynamic time-dependent displays. Our results provide a strategy for synthesizing RTP CDs with a specific lifetime and extending their application scope to high-level information security.

show abstract

Revealing the synergetic interaction between amino and carbonyl functional groups and their effect on the electronic and optical properties of carbon dots

Abstract: Nitrogen and oxygen-based functionalized Carbon dots' (CDs) surfaces have attracted significant attention owing to their ability to tailor CDs' optical and electronic properties. However, the complex synthesis process and structure...

Cited by 14 publications

References 57 publications

In Vitro and Silico Studies on the N-Doped Carbon Dots Potential in ACE2 Expression Modulation

In Vitro and Silico Studies on the N-Doped Carbon Dots Potential in ACE2 Expression Modulation

Functionalized Phytochemicals-Embedded Carbon Dots Derived from Medicinal Plant for Bioimaging Application

Machine Learning-Guided Synthesis of Room-Temperature Phosphorescent Carbon Dots for Enhanced Phosphorescence Lifetime and Information Encryption

Contact Info

Product

Resources

About