Reversal atrial electrical remodeling assessed by P-wave signal-averaging ECG following cardioversion of long-standing atrial fibrillation

Barbosa, Eduardo Corrêa; Benchimol-Barbosa, Paulo Roberto; Bomfim, Alfredo S.; Boghossian, Silvia Helena Cardoso; Veloso, Henrique Horta

doi:10.1016/j.hrthm.2005.02.955

Cited by 2 publications

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“…The only predictors of AF recurrence were left ventricular hypertrophy and previous AF duration 6 . Other studies have shown an improvement of P wave parameters after conversion of lone AF, that could suggest a reverse electrical remodeling 7 . Our study does not support reverse electrical remodeling on the short term.…”

Section: Discussioncontrasting

confidence: 76%

P Wave Signal-Averaged ECG in Normal Population and in Patients with Converted Atrial Fibrillation

Militaru

Donoiu

Ionescu

2011

Annals of Noninvasive Electrocardiology

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Section: Discussioncontrasting

confidence: 76%

P Wave Signal-Averaged ECG in Normal Population and in Patients with Converted Atrial Fibrillation

Militaru

Donoiu

Ionescu

2011

Annals of Noninvasive Electrocardiology

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“…8 A meta-analysis of PW indices showed limited improvement in risk prediction for AF compared to a robust risk score for the condition, initially derived from multiple community-based cohorts. 7 However, the results are inconsistent, [9][10][11] and most P-SAECG studies are limited by small-to-modest sample sizes with incomplete anthropometric and clinical characterization 12,13 or technical issues. 14,15 Also, which clinical risk factors are associated with P-SAECG measurements is unclear, and the heritability of P-SAECG measurements remains known.…”

Section: Introductionmentioning

confidence: 99%

P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study

et al. 2021

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BACKGROUND P-wave signal-averaged electrocardiography (P-SAECG) quantifies atrial electrical activity. P-SAECG measures and their clinical correlates and heritability have had limited characterization in community-based cohorts.OBJECTIVE The purpose of this study was to (1) establish reference values; (2) identify clinical risk factors associated with P-SAECG; and (3) estimate genetic heritability for P-SAECG traits.METHODS We performed P-SAECG in 2 generations of Framingham Heart Study participants. We performed backward elimination regression models to assess associations of clinical factors with each SAECG trait (P-wave [PW] duration, root mean square voltage in terminal 40 ms [RMS40], terminal 30 ms RMS30, terminal 20 ms RMS20, RMS PW, and PW integral). We estimated the adjusted genetic heritability of P-SAECG measures using the Sequential Oligogenic Linkage Analysis Routines (SOLAR) program. RESULTSWe included 4307 participants (age 55 6 14 years; 56% female). The reference values were derived from 1752 participants without cardiovascular risk factors. Median (2.5th percentile; 97.5th percentile) total PW duration was 118 ms (93; 146) in women and 128 ms (104; 158) in men in the reference sample, and 121 ms (94; 151) in women and 129 ms (103; 159) in the entire study cohort (broad sample). In the broad sample, after adjusting for age and sex, total PW duration was positively associated with height, weight, prevalent heart failure, history of atrial fibrillation (AF), and atrioventricular node blockers, and negatively associated with smoking, waist circumference, heart rate, and diabetes. The estimated heritability of P-SAECG traits was moderate, ranging from 11.9% for RMS30 to 24.9% for PW integral.CONCLUSION P-SAECG traits are associated with multiple AF-related risk factors and are moderately heritable.

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Reversal atrial electrical remodeling assessed by P-wave signal-averaging ECG following cardioversion of long-standing atrial fibrillation

Cited by 2 publications

References 0 publications

P Wave Signal-Averaged ECG in Normal Population and in Patients with Converted Atrial Fibrillation

P Wave Signal-Averaged ECG in Normal Population and in Patients with Converted Atrial Fibrillation

P-wave signal-averaged electrocardiography: Reference values, clinical correlates, and heritability in the Framingham Heart Study

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