Reversal by medical treatment of endometrial hyperplasia caused by estrogen replacement therapy

Abstract

Progestins are highly successful in reversing endometrial hyperplasia caused by ERT.

Levonorgestrel‐releasing intrauterine system (Mirena®) as a therapy for endometrial hyperplasia and carcinoma

“…Our results in treating the woman with endometrial hyperplasia was in accordance to a previous report (16) and to the findings of Randal & Kurman (1) who observed regression in 16 out of 17 patients with endometrial hyperplasia when they were treated with progestin. We believe that for women with atypical hyperplasia the LNG‐IUS could be an alternative, because it avoids the daily intake of medication, probably increasing the adherence to the treatment, and it could be acceptable for women who do not present clinical conditions for surgery.…”

The effects of the levonorgestrel intrauterine system (Mirena coil) on endometrial morphology

“…It is, of course, well recognised that progestogenic agents may result in reversal of endometrial hyperplasia and even well differentiated endometrioid adenocarcinomas. [12][13][14][15] Indeed, recently intrauterine progesterone containing devices have been used, with some success, for the treatment of low grade, early stage endometrioid adenocarcinomas in women who are a poor operative risk. 16 In conclusion, our study describes the endometrial morphological features associated with the Mirena coil, a progestogen containing device.…”

Endometrial cancer risk in estrogen users after switching to estrogen–progestin therapy

“…Progestin is believed to reverse endometrial hyperplasia by influencing mitosis, angiogenesis, and apoptosis [22]. Multiple studies have suggested that combined estrogen-progestin regimens may lead to reversion of hyperplasia that has resulted from unopposed estrogen use [22][23][24][25].…”