Reversal Effect of Dihydromyricetin on Multiple Drug Resistance in SGC7901/5-FU Cells

M, Wu; Jiang, Ming; Xu, Lei; Lv, Jun; Xue, Mengya; Huang, Mengzhu

doi:10.31557/apjcp.2020.21.5.1269

Cited by 10 publications

(10 citation statements)

References 23 publications

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“…The biological properties and the underlying mechanisms of DHM were investigated mostly by in vitro cell cultures and in vivo animal models. In addition, DHM was reported as toxicologically safe and could effectively reverse multidrug resistance [15][16][17][18][19]. Hence, DHM is a promising bioactive compound for developing healthy/functional foods.…”

Section: Introductionmentioning

confidence: 99%

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Chen

Shi

et al. 2021

Mediators of Inflammation

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Dihydromyricetin (DHM) is a flavonoid extracted from the leaves and stems of the edible plant Ampelopsis grossedentata that has been used for Chinese Traditional Medicine. It has attracted considerable attention from consumers due to its beneficial properties including anticancer, antioxidative, and anti-inflammatory activities. Continuous oxidative stress caused by intracellular redox imbalance can lead to chronic inflammation, which is intimately associated with the initiation, promotion, and progression of cancer. DHM is considered a potential redox regulator for chronic disease prevention, and its biological activities are abundantly evaluated by using diverse cell and animal models. However, clinical investigations are still scanty. This review summarizes the current potential chemopreventive effects of DHM, including its properties such as anticancer, antioxidative, and anti-inflammatory activities, and further discusses the underlying molecular mechanisms of DHM in cancer chemoprevention by targeting redox balance and influencing the gut microbiota.

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Section: Introductionmentioning

confidence: 99%

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Chen

Shi

et al. 2021

Mediators of Inflammation

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“…Furthermore, DHM also attenuates the drug efflux mediated by P-gp and then increases the intracellular accumulation of chemotherapeutic drugs, thereby reversing the MDR of human leukemia K562/ADR cells [ 112 ]. In addition, DHM reverses the resistance to 5-FU in SGC7901/5-FU cells in a concentration-dependent manner by downregulating MDR1 mRNA expression and impeding the pumping effect of P-gp [ 113 ], indicating that DHM can be applied as an effective MDR reversal agent in the treatment of gastric cancer. It is known that the survivin gene is a member of the inhibitor of the apoptosis protein family, and the overexpression of survivin may provide growth and survival advantages for cancer initiation and progression [ 114 ].…”

Section: Synergistic Effects Of Dihydromyricetin With Anticancer Agentsmentioning

confidence: 99%

Present Status, Challenges, and Prospects of Dihydromyricetin in the Battle against Cancer

Xiao

Zhu

et al. 2022

Cancers

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Dihydromyricetin (DHM) is a natural flavonoid compound extracted from Ampelopsis grossedentata that has been used for centuries in traditional Chinese medicine. DHM has attracted intensive attention due to its numerous beneficial activities, such as hepatoprotection, cardioprotection, antioxidant, and anti-inflammation. In addition, DHM inhibits the progression of cancers such as lung cancer, hepatocellular cancer, breast cancer, melanoma, and malignant reproductive systems through multiple mechanisms, including antiangiogenesis, antiproliferation, apoptosis, and inhibition of invasion and migration. Notably, DHM also activates autophagy at different levels, exerting a dual-regulatory effect on cancers. Mechanistically, DHM can effectively regulate mammalian target of rapamycin (mTOR), noncoding RNA-mediated signaling, phosphatidylinositol 3-kinase (PI3K)/protein kinase B (Akt) pathway, nuclear factor-κB (NF-κB), p53, and endoplasmic reticulum stress (ER stress)-driven signaling in different types of cancers. DHM has also been shown to have inhibitory effects on various regulators that trigger epithelial–mesenchymal transition (EMT). Furthermore, DHM exhibits a remarkable anticancer reversal ability when used in combination with drugs such as adriamycin, nedaplatin, and other drugs. However, the low bioavailability of DHM limits its potential applications, which are improved through structural modification and the exploration of novel dosage forms. Therefore, DHM may become a promising candidate for treating malignancies alone or combined with conventional anticancer strategies used in clinical practice.

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“…Cyclodextrins (CD) are a kind of semi-natural cyclic oligosaccharides with conical hollow structures, which can improve the solubility of drugs. The whole B ring and part of the C ring of DHM could be embedded into the cavity of CD through non-covalent interactions such as hydrogen bonding (YP Wu et al., 2020 ). Therefore, inclusion technology may be an effective strategy to improve the low water solubility of DHM.…”

Section: Pharmaceutical Designs Of Dhmmentioning

confidence: 99%

“…Therefore, the combination with DHM is an effective way to solve the above problems of ADR. In addition to platinum drugs and ADR, DHM can also improve the efficacy of all-trans retinoic acid and reverse the MDR of 5-fluorouracil through various mechanisms (Zhou et al., 2014 ; He et al., 2018 ; M Wu et al., 2020 ).…”

Section: Pharmaceutical Designs For the Combined Application Of Dhm W...mentioning

confidence: 99%

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

et al. 2022

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Dihydromyricetin (DHM) is an important natural flavonoid that has attracted much attention because of its various functions such as protecting the cardiovascular system and liver, treating cancer and neurodegenerative diseases, and anti-inflammation effect, etc. Despite its great development potential in pharmacy, DHM has some problems in pharmaceutical applications such as low solubility, permeability, and stability. To settle these issues, extensive research has been carried out on its physicochemical properties and dosage forms to produce all kinds of DHM preparations in the past ten years. In addition, the combined use of DHM with other drugs is a promising strategy to expand the application of DHM. However, although invention patents for DHM preparations have been issued in several countries, the current transformation of DHM research results into market products is insufficient. To date, there is still a lack of deep research into the pharmacokinetics, pharmacodynamics, toxicology, and action mechanism of DHM preparations. Besides, preparations for combined therapy of DHM with other drugs are scarcely reported, which necessitates the development of dosage forms for this application. Apart from medicine, the development of DHM in the food industry is also of great potential. Due to its multiple effects and excellent safety, DHM preparations can be developed for functional drinks and foods. Through this review, we hope to draw more attention to the development potential of DHM and the above challenges and provide valuable references for the research and development of other natural products with a similar structure-activity relationship to this drug.

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Reversal Effect of Dihydromyricetin on Multiple Drug Resistance in SGC7901/5-FU Cells

Cited by 10 publications

References 23 publications

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Dihydromyricetin Acts as a Potential Redox Balance Mediator in Cancer Chemoprevention

Present Status, Challenges, and Prospects of Dihydromyricetin in the Battle against Cancer

Strategic developments in the drug delivery of natural product dihydromyricetin: applications, prospects, and challenges

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