Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice

Chaves, Raquell de Castro; Mallmann, Auriana Serra Vasconcelos; Oliveira, Natália Ferreira de; Oliveira, Iris Cristina Maia; Capibaribe, Victor Celso Cavalcanti; Silva, Daniel Moreira Alves da; Lopes, Iardja Stéfane; Valentim, José Tiago; Carvalho, Alyne Mara Rodrigues de; Macêdo, Danielle Silveira; Vasconcelos, Silvânia Maria Mendes; Gutierrez, Stanley Juan Chaves; Barbosa-Filho, José Maria; Sousa, Francisca Cléa Florenço de

doi:10.1016/j.pbb.2019.03.005

Cited by 23 publications

(10 citation statements)

References 79 publications

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“…It is detected by diminished response to rewards, such as the reduced consumption of naturally preferred sweetened beverages 44 . In consistent with previous reports 38,45 , chronic Cort injection in the current study significantly decreased the sucrose preference, while oleuropein at different doses attenuated this decrease with the best improvement with the doses of 16 and 32 mg/kg and their effects were comparable to that of fluoxetine (Fig. 2c).…”

Section: Discussionsupporting

confidence: 93%

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Badr

Attia

Al-Rasheed

2020

Sci Rep

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Depression is still one of challenging, and widely encountered disorders with complex etiology. The role of healthy diet and olive oil in ameliorating depression has been claimed. This study was designed to explore the effects of oleuropein; the main constituent of olive oil; on depression-like behaviors that are induced by repeated administration of corticosterone (40 mg/kg, i.p.), once a day for 21 days, in mice. Oleuropein (8, 16, and 32 mg/kg, i.p.) or fluoxetine (20 mg/kg, positive control, i.p.1) was administered 30 minutes prior to corticosterone injection. Sucrose consumption test, open-field test (OFT), tail suspension test (TST), and forced swimming test (FST) were performed. Reduced Glutathione (GSH), lipid peroxidation, and biogenic amines; serotonin, dopamine, and nor-epinephrine; levels were also analyzed in brain homogenates. Corticosterone treatment induced depression-like behaviors, it increased immobility time in the TST, OFT, and FST, decreased the number of movements in OFT, and decreased sucrose consumption. Corticosterone effect was associated with depletion of reduced glutathione and increase of lipid peroxidation, in addition to modification of biogenic amines; decreased serotonin and dopamine. Oleuropein or fluoxetine administration counteracted corticosterone-induced changes. In conclusion, oleuropein showed a promising antidepressant activity, that is evident by improving corticosterone-induced depression-like behaviors, and normalizing levels of biogenic amines.

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Section: Discussionsupporting

confidence: 93%

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Badr

Attia

Al-Rasheed

2020

Sci Rep

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“…We used the CUMS protocol to mimic the traits of depression, which were confirmed by the SPT, FST, TST, EPM, and OFT in mice in our behavioral studies. FLU is currently available on the market [35], and the present results are consistent with previous research [36]. e CUMS mouse model has been generally used to study the pathological mechanism of depressive disorder and screening antidepressant drugs [37].…”

Section: Discussionsupporting

confidence: 90%

Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP‐43 Expression

Cao

Zhang

et al. 2020

Evidence-Based Complementary and Alternative Medicine

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Background. Nelumbo nucifera Gaertn stem (Hegeng [HG]) is a traditional Chinese medicine that is used to treat mental symptoms in East Asia. However, scientific evidence is generally lacking to support this traditional claim. Aim of the Study. This study’s aim is to investigate the antidepression effect of HG and to further explore the possible molecular mechanisms that are involved in its actions. Materials and Methods. HG aqueous extract was administered intragastrically for 21 days after the chronic unpredictable mild stress (CUMS) procedure, and its effect on memory, learning, and emotion was assessed using animal behavioral tests. HG aqueous extract was characterized using HPLC. Immunofluorescence was used to measure the neural cell-adhesion molecule (NCAM) and growth-associated protein-43 (GAP-43) expression. Results. Depression-like behaviors increased in the CUMS group compared with the control (CON) group, while they were reduced in the high-dose HG (H-HG) and fluoxetine (FLU) groups (p<0.05). Additionally, NCAM and GAP-43 expression was reduced in the CUMS group compared with the CON group, but it increased in the H-HG and FLU groups (p<0.05). Conclusions. These findings show the potential antidepressant effects of HG through mechanisms involving regulation of NCAM and GAP-43. This provides a new theoretical basis for its potential application as an antidepressant-like agent.

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“…For female mice, data are scarce. Nevertheless, the assumption that dominant females might be less anxious may be further supported by the reduced CORT serum levels in dominant females compared to submissive animals found in our study, considering that corticosterone levels have already been defined to directly relate to anxiety-like behavior ( McGill et al, 2006 ; Chaves et al, 2019 ). Since in our case, the transcriptomic analysis was performed on whole brain hemispheres, the DEGs cannot be traced back to relevant functional regions.…”

Section: Discussionsupporting

confidence: 66%

N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice

Guilherme

Tsoutsouli

Todorov

et al. 2021

Front. Cell Dev. Biol.

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Appropriately responding to stressful events is essential for maintaining health and well-being of any organism. Concerning social stress, the response is not always as straightforward as reacting to physical stressors, e.g., extreme heat, and thus has to be balanced subtly. Particularly, regulatory mechanisms contributing to gaining resilience in the face of mild social stress are not fully deciphered yet. We employed an intrinsic social hierarchy stress paradigm in mice of both sexes to identify critical factors for potential coping strategies. While global transcriptomic changes could not be observed in male mice, several genes previously reported to be involved in synaptic plasticity, learning, and anxiety-like behavior were differentially regulated in female mice. Moreover, changes in N6-methyladenosine (m6A)-modification of mRNA occurred associated with corticosterone level in both sexes with, e.g., increased global amount in submissive female mice. In accordance with this, METTL14 and WTAP, subunits of the methyltransferase complex, showed elevated levels in submissive female mice. N6-adenosyl-methylation is the most prominent type of mRNA methylation and plays a crucial role in processes such as metabolism, but also response to physical stress. Our findings underpin its essential role by also providing a link to social stress evoked by hierarchy building within same-sex groups. As recently, search for small molecule modifiers for the respective class of RNA modifying enzymes has started, this might even lead to new therapeutic approaches against stress disorders.

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Reversal effect of Riparin IV in depression and anxiety caused by corticosterone chronic administration in mice

Cited by 23 publications

References 79 publications

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Oleuropein Reverses Repeated Corticosterone-Induced Depressive-Like Behavior in mice: Evidence of Modulating Effect on Biogenic Amines

Nelumbo nucifera Gaertn Stems (Hegeng) Improved Depression Behavior in CUMS Mice by Regulating NCAM and GAP‐43 Expression

N6 -Methyladenosine Modification in Chronic Stress Response Due to Social Hierarchy Positioning of Mice

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