Reversal Effect of Vecuronium Blockade with Divided Doses of Neostigmine

Key words: reversal of neuromuscular blockade pancuronium, neostigmine) During the recovery from anesthesia, neostigmine is often administered to reverse the effects of nondepolarizing blocking agents. In our department, it has been a rule to administer the reversal drugs as slowly as p.ossible in order to avoid a vagotonic effect on the cardiovascular systems. According to Payne et aI., 1 the neostigmine itself might have neuromuscular blocking properties depending upon the methods of administration. To date there have been very few studies on such methods and the ideal one has not yet been found.The present study was designed to evaluate the rate of recovery of the Train-of-Four (TOF) ratio after administration of neostigmine by either a one slow bolus injection or a divided injection. Methods and MaterialsThe subjects of the study included 24 adulut patients (ASA class 1-2, Age 20-66 years) undergoing elective gynecologic or gastroenterologic surgery. All the patients were free from neuromuscular, renal, or hepatic diseases and were not taking any drugs known to interfere with neuromuscular functions. Informed consent was

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Accelerated reversal of pancuronium blockade with divided administration of neostigmine

Inoue

Ueda

Tsuda

et al. 1989

J Anesth

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Reversal Effect of Vecuronium Blockade with Divided Doses of Neostigmine

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Accelerated reversal of pancuronium blockade with divided administration of neostigmine

Accelerated reversal of pancuronium blockade with divided administration of neostigmine

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