Reversal Effects of Sugammadex in Diabetic Patients Having Neuromuscular Block with Rocuronium

Ersoy, Ozlem; Demiraran, Yavuz; Sezen, Gülbin; Şeker, İlknur Suidiye; Karagöz, İbrahim; Iskender, Abdülkadir; Cangür, Şengül

doi:10.5336/medsci.2014-41225

Cited by 1 publication

(1 citation statement)

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“…In our previous study to compare the time of antagonism and effect of sugammadex (2 mg/kg) which is used for antagonism of rocuronium 0.6 mg/kg on diabetic (n=21) and nondiabetic patients (n=20), we found that extubation time (time from sugammadex administration to TOF ratio reaching 0.9) was 434.6 ± 857. 1 [205 (67-4120)] s in diabetics and 250.4 ± 108.4 [247 (106-462)] seconds in nondiabetics (P = 0.948) [19].…”

Section: Discussionmentioning

confidence: 98%

The effect of vitamin D status on different neuromuscular blocker agents reverse time

Yorulmaz¹,

Demiraran²,

Özlü³

et al. 2020

Turk J Med Sci

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Background/aim This study is aimed to investigate the effects of vitamin D levels on sugammadex and neostigmine reversal times. Material and methods Eighty patients between the ages of 18 and 65 years, with ASA I-III status who were undergoing surgery under general anesthesia were included in the study. A double blind fashion was used to randomly divide all the patients into two groups. At the end of the operation, sugammadex 2 mg/kg was administered to one group (Group sugammadex) and atropine and neostigmine was administered to the other group (Group neostigmine) intravenously. In the data analysis stage, the group was divided into two subgroups according to sugammadex and group neostigmine in itself, with vitamin D levels above and below 30 ng/mL. Statistical analysis was performed on these 4 groups (Group neostigmine and vitamin D < 30 ng/mL), (Group neostigmine and vitamin D ≥ 30 ng/mL), ( Group sugammadex and vitamin D < 30 ng/mL), (Group sugammadex and vitamin D ≥ 30 ng/mL).When two responses to train of four (TOF) stimulation were taken, the following times were recorded until extubation phase. The time until TOF value 50%, 70%, 90%, and extubation were recorded. Results There were statistically significant differences between Group sugammadex and vitamin D < 30 ng/mL and Group sugammadex and vitamin D ≥ 30 ng/mL (P = 0.007) for extubation times and 50% TOF reach times (P = 0.015). However, there was no difference observed between Group neostigmine and vitamin D < 30 ng/mL and Group neostigmine and vitamin D ≥ 30 ng/mL (P = 0.999). Conclusion Vitamin D deficiency is important for anesthesiologists in terms of muscle strength and extubation time. Vitamin D deficiency seems to affect sugammadex reverse times but seems not to affect neostigmine reverse times. This conclusion needs further studies.

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Section: Discussionmentioning

confidence: 98%