Reversal of age-related deficits in object recognition memory in rats with l-deprenyl

Lima, Maria Noêmia Martins de; Laranja, Daniela Comparsi; Caldana, Fábio; Bromberg, Elke; Roesler, Rafaël; Schröder, Nadja

doi:10.1016/j.exger.2005.03.004

Cited by 92 publications

(52 citation statements)

References 48 publications

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“…The animals were placed in the centre of the arena to explore the field freely for 5 min, and the numbers of crossings and rearings were recorded (Walsh & Cummins, 1976). The OFT was used as a context habituation trial for the recognition memory test (de Lima et al 2005).…”

Section: Behavioural Testsmentioning

confidence: 99%

Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Araujo

Quines

Jardim

et al. 2017

Experimental Physiology

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Edited by: Michael White New Findings r What is the central question of this study?Monosodium glutamate causes cognitive impairment. Does resistance exercise improve the performance of rats treated with monosodium glutamate? r What is the main finding and its importance?Resistance exercise is effective against monosodium glutamate-induced memory impairment in male and female rats.Monosodium glutamate (MSG), a flavour enhancer in diets, causes cognitive impairment in rodents. Exercise has been reported to protect against impairment of memory in humans. In this study, we investigated whether resistance exercise improves the performance of male and female rats treated with MSG in tests of memory and motor co-ordination. Wistar rats received MSG [4 g (kg body weight) −1 day −1 , s.c.] from postnatal day 1 to 10. At postnatal day 60, the animals started a resistance exercise protocol in an 80 deg inclined vertical ladder apparatus and performed it during 7 weeks. Rats performed object recognition and location memory tests. Resistance exercise reduced impairment in motor co-ordination of male and female rats treated with MSG. Resistance exercise was effective against the decrease in exploratory preference in the long-term recognition memory for novel objects of male rats treated with MSG. In MSG-treated female rats, resistance exercise was effective against the decrease in exploratory preference in the novel object location test. The exploratory preference of female rats in the long-term recognition memory test was similar in all groups. The short-term memory was not altered by MSG or resistance exercise in male and female rats. This study demonstrates that MSG affected the memory of male and female rats in different ways. Resistance exercise was effective against the decrease in recognition for male rats and in location memory for female rats treated with MSG. This report demonstrates the beneficial effects of resistance exercise against the prejudice of motor condition and impairment of memory induced by MSG in male and female rats.

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Section: Behavioural Testsmentioning

confidence: 99%

Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Araujo

Quines

Jardim

et al. 2017

Experimental Physiology

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“…While it was surprising that there was no deficit, it was not unusual as the effects of age on novel object recognition have been equivocal in whether or not age-related differences have been observed [19][20][21][22][23]26,27]. The question then remains what could be contributing to these different results.…”

Section: Discussionmentioning

confidence: 82%

“…One possibility is the length of the delay period (50 minutes) that was chosen. In some studies age-related deficits were observed with approximately a one hour delay period [19,23] and in some with a 24-hour delay [20,21], while in some no deficits were found [22].…”

Section: Discussionmentioning

confidence: 99%

“…Another test used to evaluate cognitive changes is the novel object recognition task, which is based on the measurement of how much time the animal spends with the novel object versus familiar object. This task takes advantage of the fact that rats have a tendency to search for novel objects rather than the familiar ones [17][18][19], and the effect of aging on this task again has shown equivocal results [19][20][21][22][23].…”

Section: Introductionmentioning

confidence: 99%

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Novel object recognition is not affected by age despite age-related brain changes

Aktoprak¹,

Dinc²,

Günay³

et al. 2013

WJNS

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Age-related memory impairments show a progressive decline across lifespan. Studies have demonstrated equivocal results in biological and behavioral outcomes of aging. Thus, in the present study we examined the novel object recognition task at a delay period that has been shown to be impaired in aged rats of two different strains. Moreover, we used a strain of rats, Fisher 344XBrown Norway, which have published age-related biological changes in the brain. Young (10 months old) and aged (28 months old) rats were tested on a standard novel object recognition task with a 50 minutes delay period. The data showed that young and aged rats in the strain we used performed equally well on the novel object recognition task and that both young and old rats demonstrated a righthanded side preference for the novel object. Our data suggested that novel object recognition is not impaired in aged rats although both young and old rats have a demonstrated side preference. Thus, it may be that genetic differences across strains contribute to the equivocal results in behavior, and genetic variance likely influences the course of cognitive aging.

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“…The object recognition test was performed according to the methodology previously described [13]. Twelve weeks after the beginning of the controlled feeding, rats were placed in an open-field arena consisting of a wooden box (size 40 × 50 cm and 50 cm high) surrounded by a glass wall.…”

Section: Object Recognition Testmentioning

confidence: 99%

Age at onset of caloric restriction and its effects on the redox profile of the rat hippocampus

Pereira

Nardin

Souza

et al. 2016

Nutrire

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Background: The benefits of caloric restriction (CR) on the protection against age-related neurodegenerative diseases have been the subject of several studies. However, the effects of CR on the central nervous system are still poorly understood since most studies were carried out in mature animals. The present study aimed to investigate whether the age at onset of CR could differently affect the redox status of the rat hippocampus.

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Reversal of age-related deficits in object recognition memory in rats with l-deprenyl

Cited by 92 publications

References 48 publications

Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Resistance exercise reduces memory impairment induced by monosodium glutamate in male and female rats

Novel object recognition is not affected by age despite age-related brain changes

Age at onset of caloric restriction and its effects on the redox profile of the rat hippocampus

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