Reversal of akinesia and release of festination by morphine or GABA applied focally to the nucleus reticularis tegmenti pontis.

Chesire, Rebecca M.; Jung-Tung, Cheng; Teitelbaùm, Philip

doi:10.1037/0735-7044.98.4.739

Cited by 8 publications

(2 citation statements)

References 6 publications

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“…Haloperidol, a dopamine receptor blocker (D2 receptors), applied systemically in normal rats produces akinesia, but does not block festination induced by NRTP lesions (Chesire et al 1983 ). Additionally, damage to the rat NRTP or inactivation with drugs can relieve akinesia induced by systemically administered haloperidol and induce festination (Chesire et al 1984 ). Festination and gait abnormalities in monkeys have also been reported following bilateral lesions involving the cerebellar dentate nucleus (Botterell 1938 ).…”

Section: Discussionmentioning

confidence: 99%

Nucleus reticularis tegmenti pontis: a bridge between the basal ganglia and cerebellum for movement control

2023

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Neural processing in the basal ganglia is critical for normal movement. Diseases of the basal ganglia, such as Parkinson’s disease, produce a variety of movement disorders including akinesia and bradykinesia. Many believe that the basal ganglia influence movement via thalamic projections to motor areas of the cerebral cortex and through projections to the cerebellum, which also projects to the motor cortex via the thalamus. However, lesions that interrupt these thalamic pathways to the cortex have little effect on many movements, including limb movements. Yet, limb movements are severely impaired by basal ganglia disease or damage to the cerebellum. We can explain this impairment as well as the mild effects of thalamic lesions if basal ganglia and cerebellar output reach brainstem motor regions without passing through the thalamus. In this report, we describe several brainstem pathways that connect basal ganglia output to the cerebellum via nucleus reticularis tegmenti pontis (NRTP). Additionally, we propose that widespread afferent and efferent connections of NRTP with the cerebellum could integrate processing across cerebellar regions. The basal ganglia could then alter movements via descending projections of the cerebellum. Pathways through NRTP are important for the control of normal movement and may underlie deficits associated with basal ganglia disease.

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Section: Discussionmentioning

confidence: 99%

Nucleus reticularis tegmenti pontis: a bridge between the basal ganglia and cerebellum for movement control

2023

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“…Simplification could be induced via the zero-condition, or otherwise by simplifying the brain via transection, lesion or drug that reduced behavioral competency in a more graded fashion. Teitelbaum and colleagues’ innovative genius in this regard was to use the manipulations mentioned above—local hypothalamic brain lesions, circuit-wide dopamine depletion, dopamine blocking drugs or even early stages of life – combined with meticulous analyses of detailed patterns of behavior—as tools to reveal underlying structure [12,13,24,49,50,58,72]. A complex pattern of behavior could be taken apart to reveal cascades of coordinated reflexes contained inside.…”

Section: Principles Of Psychology and Brain Functionmentioning

confidence: 99%

Contributions of Philip Teitelbaum to affective neuroscience

Berridge

2012

Behavioural Brain Research

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As part of a festschrift issue for Philip Teitelbaum, I offer here the thesis that Teitelbaum deserves to be viewed as an important forefather to the contemporary field of affective neuroscience (which studies motivation, emotion and affect in the brain). Teitelbaum’s groundbreaking analyses of motivation deficits induced by lateral hypothalamic damage, of roles of food palatability in revealing residual function, and of recovery of ‘lost’ functions helped shape modern understanding of how motivation circuits operate within the brain. His redefinition of the minimum requirement for identifying motivation raised the conceptual bar for thinking about the topic among behavioral neuroscientists. His meticulous analyses of patterned stages induced by brain manipulations, life development and clinical disorders added new dimensions to our appreciation of how brain systems work. His steadfast highlighting of integrative functions and behavioral complexity helped provide a healthy functionalist counterbalance to reductionist trends in science of the late 20th century. In short, Philip Teitelbaum can be seen to have made remarkable contributions to several domains of psychology and neuroscience, including affective neuroscience.

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Brain sites mediating opiate-induced muscle rigidity in the rat: methylnaloxonium mapping study

et al. 1991

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Reversal of akinesia and release of festination by morphine or GABA applied focally to the nucleus reticularis tegmenti pontis.

Cited by 8 publications

References 6 publications

Nucleus reticularis tegmenti pontis: a bridge between the basal ganglia and cerebellum for movement control

Nucleus reticularis tegmenti pontis: a bridge between the basal ganglia and cerebellum for movement control

Contributions of Philip Teitelbaum to affective neuroscience

Brain sites mediating opiate-induced muscle rigidity in the rat: methylnaloxonium mapping study

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