Reversal of hepatic steatosis by omega‐3 fatty acids measured non‐invasively by ¹H‐magnetic resonance spectroscopy in a rat model

Abstract

Omega-3 FA are capable of reversing severe hepatic MaS and ameliorating pathophysiological features of non-alcoholic steatohepatitis such as hepatocellular damage, lobular inflammation, and a reduced antioxidative capacity.

Obesity Etiology: Examination of Fast-Food Eating among College Students

“…With 70% mortality and 75% of the health care budget in the US related to chronic disease, a corollary pre-disposition to develop obesity, discovering the etiological dynamics associated with our food consumption, and contingent negative health outcomes when positive food selection practices are ignored, is paramount [43]. Further research into the motivations for food selection, understanding biochemical and physiological cascades from both positive and negative food selection-such as, refined grains, soda, and artificial sweeteners, substances that promote and maintain the intestinal ecosystem, as 11 …”

“…NAFLD is strongly associated with visceral adiposity [9] and visceral adiposity is considered to be the more hazardous body fat [4,9,10]. NAFLD can be induced in mice by a three week methionine and choline deficient diet [11]. It is well established that a diet lacking sufficient B vitamins results in altered methionine pathways and the production of homocysteine, an inflammatory marker, and that choline and inositol are required for phase two liver detoxification [12,13].…”

“…Adipose tissue as an endocrine organ increases proinflammatory cytokines, free fatty acids, TNFα, IL6, IL8 [11] compounding the triglyceride/cytokine hepatic insult and leads to hepatic lipid peroxidation, inflammation, hepatosteatosis, possible diagnosis of NAFLD, impaired insulin signaling, insulin and other hormonal imbalances (leptin, ghrelin, resistin), NASH diagnosis, and impaired lung function in elderly men and women [4,17,18]. NASH diagnosis is confirmed by a combination of intact and cleaved cytokeratin18 (CK-18), serum adiponectin and serum resistin [12,13,19,20].…”

Omega-3 Fatty Acid Improve Non Alcoholic Fatty Liver Induced by High Fat Diet in Rats.

“…Group III:-(omega-3-fatty acid treated group): rats were fed on the high fat diet for 20 weeks and administered fish oil daily for the last two consecutive weeks via oral gavage in a dose accounting for (0.8 gm/ kg body weight) of Omega-3fatty acid [11,12] The rats were weighed then sacrificed at the end of the experiment after about 18 hours fasting to minimize variation in lipid pattern during two successive days after blood samples have been collected from retro -orbital veins into tubes containing EDTA and centrifuged at 1500 RPM for 30 minutes. An aliquot of the separated plasma was used for immediate estimation of fasting blood glucose.…”

Importância da relação dos ácidos graxos omega-6/omega-3 na alimentação

“…Por outro lado, em muitos casos o efeito primário na esteatose microgoticular é uma anomalia mitocondrial que inclui a betaoxidação mitocondrial de ácidos graxos (HAUTEKEETE; DEGOTT; BENHAMOU, 1990). Marsman et al (2011) induziram esteatose em ratos Wistar durante três semanas suplementando esses animais posteriormente com solução enriquecida com Omega 3 e outra solução com baixíssimo teor deste ácido graxo e alto teor de Omega 6 e um grupo controle que recebeu ração comercial. Após três semanas de tratamento observaram acentuada redução da esteatose nos animais que receberam Omega 3 e lesão significativa nos animais que receberam lipídios com alto teor de Omega 6 e baixo em Omega 3.…”