Reversal of Inflammatory Bowel Disease (IBD) with Recurrent Faecal Microbiota Transplants (FMT)

Borody, Thomas J.; Torres, Margaux; Campbell, John; Leis, Sharyn; Nowak, Adriana

doi:10.14309/00000434-201110002-00979

Cited by 24 publications

(18 citation statements)

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“…Amongst these were 159 procedures for ulcerative colitis (83,(87)(88)(89)(90)(91)(92)(93)(94)(95)(96)(97)(98)(99)(100) and 67 for Crohn's. (92,(100)(101)(102)(103)(104)(105)(106)(107) In addition eight patients underwent FMT for pouchitis following restorative proctocolectomy for ulcerative colitis, (108) three for mixed UC/Crohns (109) or IBD unspecified. (110) Concomitant CDI was present in 6 patients.…”

Section: Fmt To Treat Inflammatory Bowel Diseasementioning

confidence: 99%

“…(110) Concomitant CDI was present in 6 patients. (90,93) Publications ranged from four single case reports (99,106,107,110) to series ranging from 3 (97,109) to 62 patients. (89)…”

Section: Fmt To Treat Inflammatory Bowel Diseasementioning

confidence: 99%

“…(110) Rectal enema was described using a variety of regimens in 17 cases. (94,98,109) Training in self-administration of FMT allowed one patient to complete 69 procedures in total, initially daily then weekly. (109) A plethora of other methods of administration combine different routes in largely inconsistent regimens, including 25 cases of initial colonoscopic FMT (90,93,97,105,109) and one case of initial naso-jejunal infusion (93) followed by a variable number of rectal enemas.…”

Section: Modes Of Deliverymentioning

confidence: 99%

See 2 more Smart Citations

Adverse events in faecal microbiota transplant: a review of the literature

Baxter

Colville

2016

Journal of Hospital Infection

163

122

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Section: Fmt To Treat Inflammatory Bowel Diseasementioning

confidence: 99%

“…(110) Concomitant CDI was present in 6 patients. (90,93) Publications ranged from four single case reports (99,106,107,110) to series ranging from 3 (97,109) to 62 patients. (89)…”

Section: Fmt To Treat Inflammatory Bowel Diseasementioning

confidence: 99%

Section: Modes Of Deliverymentioning

confidence: 99%

See 1 more Smart Citation

Adverse events in faecal microbiota transplant: a review of the literature

Baxter

Colville

2016

Journal of Hospital Infection

163

122

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“…83.3% (667/801) patients received only one therapy (number of therapies not reported in 43 patients), but if None it did not work, another one or more transplantation could be administered up to as many as 69. 59 There are insufficient published data to establish a relationship between the frequency of FMT and its success rate.…”

Section: Route Of Administrationmentioning

confidence: 99%

Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children

Sha

Liang

Chen

et al. 2014

Aliment Pharmacol Ther

120

109

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“…Fecal microbiota transplantation (FMT) aims to modify the intestinal microbiota composition and function of the recipients by transferring donor fecal suspension into the gastrointestinal tract of a recipient, and has become a promising method for manipulating the gut microbiota. Its successful application for the treatment of Clostridium difficile infection has inspired people to apply it to inflammatory bowel disease patients ( 4,5,6,7,8,9 ). However, this application is still in its early stages.…”

Section: Introductionmentioning

confidence: 99%

Fecal microbiota transplantation brings about bacterial strain displacement in patients with inflammatory bowel diseases

Zou

Jie

Cui

et al. 2018

Preprint

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Fecal microbiota transplantation (FMT), which is thought to have the potential to correct dysbiosis of gut microbiota, has recently been used to treat inflammatory bowel disease (IBD). To elucidate the extent and principles of microbiota engraftment in IBD patients after FMT treatment, we conducted an interventional prospective cohort study. The cohort included two categories of patients: (1) patients with moderate to severe Crohn’s disease (CD) (Harvey-Bradshaw Index ≥ 7, n = 11, and (2) patients with ulcerative colitis (UC) (Montreal classification, S2 and S3, n = 4). All patients were treated with a single FMT (via mid-gut, from healthy donors) and follow-up visits were performed at baseline, 3 days, one week, and one month after FMT (missing time points included). At each follow-up time point, fecal samples of the participants were collected along with their clinical metadata. For comparative analysis, 10 fecal samples from 10 healthy people were included to represent the diversity level of normal gut microbiota. Additionally, the metagenomic data of 25 fecal samples from 5 individuals with metabolic syndrome who underwent autologous FMT treatment were downloaded from a previous published paper to represent natural microbiota shifts during FMT. All fecal samples underwent shotgun metagenomic sequencing.We found that 3 days after FMT, 11 out of 15 recipients were in remission (3 out of 4 UC recipients; 8 out of 11 CD recipients). Generally, bacterial colonization was observed to be lower in CD recipients than in UC recipients at both species and strain levels. Furthermore, across species, different strains displayed disease-specific displacement advantages under two-disease status. Finally, most post-FMT species (> 80%) could be properly predicted (AUC > 85%) using a random forest classification model, with the gut microbiota composition and clinical parameters of pre-FMT recipients acting as the most contributive factors for prediction accuracy.

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Reversal of Inflammatory Bowel Disease (IBD) with Recurrent Faecal Microbiota Transplants (FMT)

Cited by 24 publications

References 0 publications

Adverse events in faecal microbiota transplant: a review of the literature

Adverse events in faecal microbiota transplant: a review of the literature

Systematic review: faecal microbiota transplantation therapy for digestive and nondigestive disorders in adults and children

Fecal microbiota transplantation brings about bacterial strain displacement in patients with inflammatory bowel diseases

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