1982
DOI: 10.1016/0002-9149(82)91961-0
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Reversal of left ventricular hypertrophy in hypertensive patients treated with methyldopa

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Cited by 228 publications
(40 citation statements)
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“…Discrepancies between LVW and blood pressure levels have been reported in humans 29 " 31 and in spontaneously hypertensive rats, 3 2 " suggesting that factors other than tension are involved in modulating the reversal of hypertensive left ventricular hypertrophy. 33 -33 In the present animal model (two-kidney, one clip Goldblart model), the ventricular hypertrophy was predominantly influenced by the pressure rate.…”
Section: Discussionmentioning
confidence: 99%
“…Discrepancies between LVW and blood pressure levels have been reported in humans 29 " 31 and in spontaneously hypertensive rats, 3 2 " suggesting that factors other than tension are involved in modulating the reversal of hypertensive left ventricular hypertrophy. 33 -33 In the present animal model (two-kidney, one clip Goldblart model), the ventricular hypertrophy was predominantly influenced by the pressure rate.…”
Section: Discussionmentioning
confidence: 99%
“…Secondly, most of the centers demonstrated either a lack of or a relatively poor correlation between the degree of blood pressure control and the regression of left ventricular hypertrophy. 5 " 9 The correlation between mass and pressure reportedly improved by utilizing averages of 24-hour blood pressure recordings rather than casual blood pressure levels, but even then, the index of determina-tion reached only 36% at best. l0 Finally, reversal of left ventricular hypertrophy did not occur equally in all individuals treated with the same medication.…”
mentioning
confidence: 99%
“…29 Echocardiographic tracings were coded and read blind and in random order by two expert observers blinded to the protocol. End-diastolic measurements of IVST, left ventricular internal dimension (LVID), and posterior wall thickness (PWT) were made according to the Penn convention protocol to measure LVM.11 This was calculated by the simple and anatomically validated formula LVM = 1.04 ((IVST + LVID + PWT)3 -LVID3) -13.6.…”
mentioning
confidence: 99%