Reversal of low bone density with a gluten-free diet in children and adolescents with celiac disease

Mora, Stefano; Barera, Graziano; Ricotti, Alberto; Weber, Giovanna; Bianchi, Cesare; Chiumello, G

doi:10.1093/ajcn/67.3.477

Cited by 130 publications

(109 citation statements)

References 38 publications

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“…Effect of gluten-free diet C Tau et al of those who were older at the time of diagnosis and treatment. Mora et al (1998) found spine and whole-body BMD of children with celiac disease to increase 0.06 g/cm 2 and 0.05 g/cm 2 , respectively, after 1.470.04 years on GFD. According to these authors, BMD was normal at the end of the study.…”

Section: Discussionmentioning

confidence: 86%

“…BMD has been found to increase after GFD in adults, without reaching normal values (Mautalen et al, 1997). Although several studies have assessed bone mass in children with celiac disease (Exner et al, 1978;Mora et al, 1993;Scotta et al, 1997;Mora et al, 1998Mora et al, , 1999Rea et al, 1998;Muzzo et al, 2000), most of them comprised a population of older patients.…”

Section: Introductionmentioning

confidence: 99%

“…Bone mass improves when children follow GFD (Mora et al, 1993;Scotta et al, 1997;Mora et al, 1998Mora et al, , 1999Rea et al, 1998;Muzzo et al, 2000). However, it is not definitively established whether GFD restores bone mass to normal values.…”

Section: Introductionmentioning

confidence: 99%

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Bone mineral density in children with celiac disease. Effect of a Gluten-free diet

Tau

Mautalén²,

Rosa

et al. 2005

Eur J Clin Nutr

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Objective: To assess the degree of osteopenia in children with celiac disease (CD) at the time of diagnosis and the effect of a gluten-free diet (GFD). Design: Longitudinal and prospective study. Subjets: In total, 24 children (18 girls, six boys) diagnosed with CD by means of an intestinal biopsy were included in the study. Mean7s.d. age was 4.974.3 years. In all, 16 patients were under (2.2070.82 year) and eight were over the age of 4 years (10.3072.90 year). The time between the first symptoms and diagnosis was 17.30724.70 months (range: 2-109 months). Spine bone mineral content (BMC), area and bone mineral density (BMD) were measured by DXA at baseline and 1.1770.93 years after GFD. Results: Before treatment, mean7s.d. BMD was 0.4670.13 g/cm 2 , the BMD Z-score was À1.3671.20, and was below À1 s.d. in 14 patients (58%). BMC, area and BMD increased significantly on GFD. BMD increased from 0.4670.13 to 0.5570.13 g/cm 2 (Po0.001). BMD Z-score improved from À1.3671.20 to À0.2371.20 after GFD. However, BMD increased more than 1 s.d. in 15 of the 16 children under the age of 4 years, a similar increase was only observed in four of the eight children aged more than 4 years, some of whom did not follow GFD strictly. Height and weight increased significantly with GFD (Po0.001) and the increase correlated positively with the increase in BMD. Conclusions: Axial BMD below À1 s.d. was found in 58% of children with celiac disease. Axial bone mass reverted to normal values in most children under the age of 4, who had low bone mass, all of whom followed GFD strictly.

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Section: Discussionmentioning

confidence: 86%

Section: Introductionmentioning

confidence: 99%

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Bone mineral density in children with celiac disease. Effect of a Gluten-free diet

Tau

Mautalén²,

Rosa

et al. 2005

Eur J Clin Nutr

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“…Lewis et al (35) observed that years of exposure to gluten before diagnosis of CD do not appear to influence BMD significantly. The relationship between GFD and bone restoration seems to be more pronounced in paediatric population (36,37): one year long GFD did not improve BMD in adult population according to the previously mentioned Irish study (23).…”

Section: Discussionmentioning

confidence: 91%

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Lőrinczy

Juhász

Csontos

et al. 2013

Rev. esp. enferm. dig.

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Introduction and objectives: coeliac disease (CD) and its cutaneous manifestation, dermatitis herpetiformis are both (DH) glutensensitive diseases. Metabolic bone disease is common among patients with CD, even in asymptomatic forms. Data are scarce about bone density in patients with dermatitis herpetiformis. The aim of our study was to compare bone mineral density (BMD) of celiac and dermatitis herpetiformis patients.Methods: 34 coeliac patients, 53 with dermatitis herpetiformis and 42 healthy controls were studied. The mean age was 38.0 ± 12.1, 32.18 ± 14.95, 35.33 ± 10.41 years in CD, dermatitis herpetiformis, and healthy controls, respectively. Bone mineral density of the lumbar spine, the left femoral neck and radius were measured by dual-energy X-ray absorptiometry. Low bone density, osteopenia and osteoporosis were defined as a body mass density (BMD) T-score between 0 and -1, between -1 and -2.5, and under -2.5, respectively.Results: at lumbar region, consisting of dominantly trabecular compartment, a decreased BMD was detected in 49 % (n = 26) patients with dermatitis herpetiformis, 62 % (n = 21) of CD patients, and 29 % (n = 12) of healthy controls, respectively. Lower BMD were measured at the lumbar region in dermatitis herpetiformis and CD compared to healthy subjects (0.993 ± 0.136 g/cm 2 and 0.880 ± 0.155 g/cm 2 vs. 1.056 ± 0.126 g/cm 2 ; p < 0.01). Density of bones consisting of dominantly cortical compartment (femoral neck) did not differ in dermatitis herpetiformis and healthy subjects.Conclusions: our results show that a low bone mass is also frequent among patients with dermatitis herpetiformis. Bone mineral content in these patients is significantly lower in those parts of the skeleton which contain more trabecular than cortical bone.

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“…[8][9][10] In contrast, other studies showed that an impaired skeletal development during childhood may be largely reversible when treating underlying diseases. [11][12][13] Age-and sex-specific bone reference values can help to assess skeletal development during childhood and to compare the bone health status of a child with that of a healthy population having the same age, sex and ethnicity. Thus, deviations from a normal skeletal development may be identified in an early stage.…”

Section: Introductionmentioning

confidence: 99%

Reference values of bone stiffness index and C-terminal telopeptide in healthy European children

et al. 2014

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,9 on behalf of the IDEFICS consortium BACKGROUND/OBJECTIVE: Quantitative ultrasound measurements and bone metabolic markers can help to monitor bone health and to detect impaired skeletal development. Population-based reference values for children may serve as a basis for preventive measures to reduce the risk of osteoporosis and osteoporotic fractures in later life. This is the first paper providing age-, sex-and height-specific reference values for bone stiffness index (SI) and serum carboxy-terminal cross-linking telopeptide of type I collagen (CTX) in healthy, apparently prepubertal children. SUBJECTS/METHODS: In the population-based IDEFICS baseline survey (2007)(2008) and follow-up (2009-2010), 18 745 children from eight European countries were newly recruited. A total of 10 791 2-10.9-year-old and 1646 3-8.9-year-old healthy children provided data on SI of the right and left calcaneus and serum CTX, respectively. Furthermore, height and weight were measured. Percentile curves were calculated using the General Additive Model for Location Scale and Shape (GAMLSS) to model the distribution of SI and CTX depending on multiple covariates while accounting for dispersion, skewness, and the kurtosis of this distribution. RESULTS: SI was negatively associated with age and height in children aged 2-5 years, whereas a positive association was observed in children aged 6-10 years. The dip in SI occurred at older age for higher SI percentiles and was observed earlier in taller children than in smaller children. The CTX reference curves showed a linear-positive association with age and height. No major sex differences were observed for the SI and CTX reference values. CONCLUSION: These reference data lay the ground to evaluate bone growth and metabolism in prepubertal children in epidemiological and clinical settings. They may also inform clinical practice to monitor skeletal development and to assess adverse drug reactions during medical treatments.

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Reversal of low bone density with a gluten-free diet in children and adolescents with celiac disease

Cited by 130 publications

References 38 publications

Bone mineral density in children with celiac disease. Effect of a Gluten-free diet

Bone mineral density in children with celiac disease. Effect of a Gluten-free diet

Does dermatitis herpetiformis result in bone loss as coeliac disease does?: a cross sectional study

Reference values of bone stiffness index and C-terminal telopeptide in healthy European children

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