Reversal of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation

Leite, Joaquim Barbosa; Bastos, João Marcos de Mello; Samuels, Richard Ian; Carey, Robert J.; Carrera, Marinete Pinheiro

doi:10.1016/j.bbr.2018.08.009

Cited by 25 publications

(3 citation statements)

References 45 publications

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“…In 2020, the highest incidence occurred between May to July and from November to September. The incidence rate of COVID-19 in general in Iran also increased very rapidly between November 1 and December 30, 2020, so that the number of patients reached 1,200,000 from about 600,000 (Leite Junior et al 2019 ). In the period from May to July 2020, there were events such as Muslim holidays and Ramadan, when people go to visit relatives and religious gatherings.…”

Section: Discussionmentioning

confidence: 99%

Changes in incidence and mortality trend due to COVID-19 in southern Iran, from 2020 to 2021: based on Cochran–Armitage trend test

Rezaei

Shahedi

Keshtkaran

et al. 2023

J Public Health (Berl.)

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Background In 2020, COVID-19 spread rapidly in Iran and other parts of the world. Some of the epidemiological aspects of this disease remain unknown; therefore, the present study was designed with the aim of determining the trend of incidence and mortality of COVID-19 from February 2020 to July 2021 in southern Iran. Methods The present study was a cross-sectional analytical study that included all people who had COVID-19 in the period from February 2020 to July 2021 and whose information had been registered in the Infectious Diseases Center of Larestan city and MCMC unit. The study area included the cities of Larestan, Evaz, and Khonj, located in the south of Fars province in southern Iran. Results Since the emergence of COVID-19 until July 2021, a total of 23,246 new cases of infection were reported in the southern region of Fars province. The average age of patients was 39.90±18.30 years and the range of ages varied from 1 to 103 years. The results of the Cochran–Armitage trend test showed that the trend of the disease in 2020 was completely upward. The first positive case of COVID-19 was recorded on February 27, 2020. The incidence curve in 2021 is sinusoidal, but in general, the results of the Cochran–Armitage trend test showed that the incidence of the disease increased significantly ( P -trend < 0.001). Most cases were reported in July, April, and the end of March. Conclusion In general, the incidence rate of COVID-19 has varied sinusoidally from 2020 to mid-2021. Although the incidence of the disease increased, the number of deaths has fallen. It seems that the increase in the number of diagnostic tests and the implementation of the national COVID-19 immunization program have been effective in changing the trend of the disease.

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Section: Discussionmentioning

confidence: 99%

Changes in incidence and mortality trend due to COVID-19 in southern Iran, from 2020 to 2021: based on Cochran–Armitage trend test

Rezaei

Shahedi

Keshtkaran

et al. 2023

J Public Health (Berl.)

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“…The use of morphine in all patients after surgery limited the pain intensity to mild-tomoderate levels. Morphine acts by binding to mu-opioid receptors in the central and peripheral nervous systems, activating descending inhibitory pathways and reducing pain transmission [18][19][20] .…”

Section: Discussionmentioning

confidence: 99%

Correlation between Various Factors and Pain in Gynecological Cancer Patients within the First 24 Hours Post-Operation: A Study in an Urban-Based Tertiary Medical Center

Pairat,

Kittikhungovit,

Niwatkittipon

et al. 2024

Vajira Med J

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OBJECTIVE: To investigate various pain factors in patients with gynecological cancer who have undergone different types of elective hysterectomy.METHODS: In this retrospective study, data on pain assessment were collected from gynecological cancer patients who underwent elective total abdominal hysterectomy or total laparoscopic hysterectomy surgeries (with associated surgery) between January 2019 and December 2022 at Vajira Hospital. The data were gathered starting from 24 hours after the procedures.RESULTS: The pain assessment was evaluated using the Numerical Rating Scale (ranging from 0 to 10, representing low to severe pain) during the first 24 hours after the surgery. The results revealed that several factors, such as cancer location, prior surgical history, and body weight, influenced the intensity and onset of pain. However, different types of surgery did not have a significant impact on pain assessment. Moreover, patients with cancer lesions in the endometrium experienced an early onset of severe pain. Additionally, patients without previous surgical experience and those who are obese should receive additional attention in terms of pain management.CONCLUSION: This study sheds light on evidence-based factors that influence pain intensity and/or pain onset, including cancer location, prior surgical history, and body mass index. Understanding these factors can contribute to more effective pain management strategies for gynecological patients’ post-surgery.

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“…Devi et al (1970);Rahimtoola et al (1970);Gueron et al (1992);Sibley et al (1993);Bawaskar and Bawaskar, (1994); Reddy, (2013);Pandurang et al (2014);Bhoite et al (2015);Akella et al (2016);Junior et al (2019) …”

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confidence: 99%

Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins

2021

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The Indian red scorpion (Mesobuthus tamulus) is one of the world’s deadliest scorpions, with stings representing a life-threatening medical emergency. This species is distributed throughout the Indian sub-continent, including eastern Pakistan, eastern Nepal, and Sri Lanka. In India, Indian red scorpions are broadly distributed in western Maharashtra, Saurashtra, Kerala, Andhra Pradesh, Tamil Nadu, and Karnataka; however, fatal envenomations have been recorded primarily in the Konkan region of Maharashtra. The Indian red scorpion venom proteome comprises 110 proteins belonging to 13 venom protein families. The significant pharmacological activity is predominantly caused by the low molecular mass non-enzymatic Na+ and K+ ion channel toxins. Other minor toxins comprise 15.6% of the total venom proteome. Indian red scorpion stings induce the release of catecholamine, which leads to pathophysiological abnormalities in the victim. A strong correlation has been observed between venom proteome composition and local (swelling, redness, heat, and regional lymph node involvement) and systemic (tachycardia, mydriasis, hyperglycemia, hypertension, toxic myocarditis, cardiac failure, and pulmonary edema) manifestations. Immediate administration of antivenom is the preferred treatment for Indian red scorpion stings. However, scorpion-specific antivenoms have exhibited poor immunorecognition and neutralization of the low molecular mass toxins. The proteomic analysis also suggests that Indian red scorpion venom is a rich source of pharmacologically active molecules that may be envisaged as drug prototypes. The following review summarizes the progress made towards understanding the venom proteome of the Indian red scorpion and addresses the current understanding of the pathophysiology associated with its sting.

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Reversal of morphine conditioned behavior by an anti-dopaminergic post-trial drug treatment during re-consolidation

Cited by 25 publications

References 45 publications

Changes in incidence and mortality trend due to COVID-19 in southern Iran, from 2020 to 2021: based on Cochran–Armitage trend test

Changes in incidence and mortality trend due to COVID-19 in southern Iran, from 2020 to 2021: based on Cochran–Armitage trend test

Correlation between Various Factors and Pain in Gynecological Cancer Patients within the First 24 Hours Post-Operation: A Study in an Urban-Based Tertiary Medical Center

Biochemical and Proteomic Characterization, and Pharmacological Insights of Indian Red Scorpion Venom Toxins

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