2023
DOI: 10.2174/1566523223666221027113723
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Reversal of Neuropsychiatric Comorbidities in an Animal Model of Temporal Lobe Epilepsy Following Systemic Administration of Dental Pulp Stem Cells and Bone Marrow Mesenchymal Stem Cells

Abstract: Introduction: We aim to investigate whether timed systemic administration of dental pulp stem cells (DPSCs) or bone marrow mesenchymal stem cells (BM-MSCs) with status epilepticus (SE) induced blood-brain barrier (BBB) damage could facilitate the CNS homing of DPSCs/BM-MSCs and mitigate neurodegeneration, neuroinflammation and neuropsychiatric comorbidities in animal model of Temporal Lobe epilepsy (TLE). Background: Cognitive impairments, altered emotional responsiveness, depression, and anxiety are the com… Show more

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Cited by 6 publications
(1 citation statement)
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“…NFTs have a key role in the creation of an appropriate neural microenvironment via the promotion of neural differentiation, neuronal survival, axon regeneration, and neurite outgrowth (Luzuriaga et al 2021). Recently, many cell-based strategies have been conducted to assess the pre-clinical e cacy of different types of MSCs for the treatment of epilepsy including; bone marrow-derived mesenchymal stem cells (BMSCs) (Salem et al 2018), Adipose tissue-derived mesenchymal stem cells (ADSCs) (Wang et al 2021), human umbilical mesenchymal stem cell (HU-MSC) (Mohammed et al 2014, Huang et al 2016, and dental pulp stem cells (DPSCs) (Senthilkumar et al 2022). MSCs have also attracted attention in the clinical eld as a potential therapeutic option for the treatment of epilepsy which can reduce the frequency of seizures (Hlebokazov, Dakukina et al 2017, Milczarek et al 2018).…”
Section: Introductionmentioning
confidence: 99%
“…NFTs have a key role in the creation of an appropriate neural microenvironment via the promotion of neural differentiation, neuronal survival, axon regeneration, and neurite outgrowth (Luzuriaga et al 2021). Recently, many cell-based strategies have been conducted to assess the pre-clinical e cacy of different types of MSCs for the treatment of epilepsy including; bone marrow-derived mesenchymal stem cells (BMSCs) (Salem et al 2018), Adipose tissue-derived mesenchymal stem cells (ADSCs) (Wang et al 2021), human umbilical mesenchymal stem cell (HU-MSC) (Mohammed et al 2014, Huang et al 2016, and dental pulp stem cells (DPSCs) (Senthilkumar et al 2022). MSCs have also attracted attention in the clinical eld as a potential therapeutic option for the treatment of epilepsy which can reduce the frequency of seizures (Hlebokazov, Dakukina et al 2017, Milczarek et al 2018).…”
Section: Introductionmentioning
confidence: 99%