Reversal of neurovascular coupling in the default mode network: Evidence from hypoxia

Rossetti, Gabriella; d’Avossa, Giovanni; Rogan, Matthew; Macdonald, Jamie; Oliver, Samuel J.; Mullins, Paul G.

doi:10.1177/0271678x20930827

Cited by 20 publications

(15 citation statements)

References 68 publications

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“…Mild acute hypoxia modulates neurovascular coupling ( 40 , 41 ) and cerebral blood flow (CBF) according to the brain region ( 42 ). We thus tested whether decreasing the percentage of oxygen inhaled could enhance the initial dip.…”

Section: Resultsmentioning

confidence: 99%

The oxygen initial dip in the brain of anesthetized and awake mice

Aydin

Verdier

Chaigneau

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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Significance Sensory stimulation generates a robust decrease in oxygen concentration (pO 2 initial dip) in brain tissue of anesthetized cats and rodents. This dip reports local activation of neurons much better than the delayed pO 2 increase associated with functional hyperemia. Here, we reinvestigated the issue in animals that recovered from acute surgery using two-photon lifetime microscopy. Targeting a distinct neuronal network that is the site of strong activation and energy consumption, we show that in anesthetized animals the pO 2 initial dip is present but extremely small in juxtasynaptic capillaries. In awake animals, it is no longer detectable in vessels or in the neuropil. This demonstrates that in healthy animals, neurovascular coupling is too fast and efficient to reveal a pO 2 initial dip.

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Section: Resultsmentioning

confidence: 99%

The oxygen initial dip in the brain of anesthetized and awake mice

Aydin

Verdier

Chaigneau

et al. 2022

Proc. Natl. Acad. Sci. U.S.A.

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“…During acute hypoxia when arterial oxygen content is reduced, global cerebral blood flow increases (Hoiland et al., 2018). However, hypoxia‐induced changes in blood flow are not uniform across the brain (Lawley et al., 2017; Rossetti et al., 2021), which may in part relate to different regulation of blood flow at the extracranial arteries (Lewis et al., 2014; Ogoh et al., 2013; Subudhi et al., 2014; Willie et al., 2012).…”

Section: Introductionmentioning

confidence: 99%

Bilateral regional extracranial blood flow regulation to hypoxia and unilateral duplex ultrasound measurement error

Friend

Rogan

Rossetti

et al. 2021

Experimental Physiology

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Whether blood flow regulation to hypoxia is similar between left and right internal carotid arteries (ICAs) and vertebral arteries (VAs) is unclear. Extracranial blood flow is regularly calculated by doubling a unilateral assessment; however, lateral artery differences may lead to measurement error. This study aimed to determine extracranial blood flow regulation to hypoxia when factoring for vessel type (ICAs or VAs) and vessel side (left or right) effects, and to investigate unilateral assessment measurement error compared to bilateral assessment. In a repeated-measures crossover design, extracranial arteries of 44 participants were assessed bilaterally by duplex ultrasound during 90 min of normoxic and poikilocapnic hypoxic (12.0% fraction of inspired oxygen) conditions. Linear mixed model analyses revealed no Condition × Vessel Type × Vessel Side interaction for blood flow, vessel diameter and flow velocity (all P > 0.05) indicating left and right ICA and VA blood flow regulation to hypoxia was similar. Bilateral hypoxic reactivity was comparable (ICAs, 1.4 (1.0) vs. VAs, 1.7 (1.1) Δ%Δ⋅S pO 2 −1 ; P = 0.12). Compared to bilateral assessment, unilateral mean measurement error of the relative blood flow response to hypoxia was up to 5%, but individual errors reached 37% and were greatest in ICAs and VAs with the smaller resting blood flow due to a ratio-scaling problem. In conclusion, left and right ICA and VA regulation to hypoxia is comparable when factoring for vessel type and vessel side.Assessing the ICA and VA vessels with the larger resting blood flow, not the left or right vessel, reduces unilateral measurement error.

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“…The brain function was in an interactive model with complex integrity; thus, the brain network theory was proposed to explore the brain functional activity in detail [ 72 , 73 ]. Using ICA and other techniques, the functional changes of different brain network models were uncovered [ 74 ]; for example, the default-model network was considered to reflect the spontaneous brain activity on the resting state, playing a key role in revealing the self-generated cognitive function [ 75 ], and the frontoparietal network was suggested to be associated with the creation of verbal language [ 76 ]; the attention network is defined as modulating the orienting, alerting, and executive work, and so on [ 77 ]. The damage of the cerebral anatomy structure integrity resulted in the impairment of language function [ 78 , 79 ].…”

Section: Resultsmentioning

confidence: 99%

Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review

Deng

Sang

et al. 2022

Neural Plasticity

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Background. Aphasia is a common symptom in stroke patients, presenting with the impairment of spontaneous speech, repetition, naming, auditory comprehension, reading, and writing function. Multiple rehabilitation methods have been suggested for the recovery of poststroke aphasia, including medication treatment, behavioral therapy, and stimulation approach. Acupuncture has been proven to have a beneficial effect on improving speech functions in repetition, oral speech, reading, comprehension, and writing ability. Neuroimaging technology provides a visualized way to explore cerebral neural activity, which helps reveal the therapeutic effect of acupuncture therapy. In this systematic review, we aim to reveal and summarize the neuroimaging mechanism of acupuncture therapy on poststroke aphasia to provide the foundation for further study. Methods. Seven electronic databases were searched including PubMed, Web of Science, Embase, Cochrane Central Register of Controlled Trials, China National Knowledge Infrastructure, the Wanfang databases, and the Chinese Scientific Journal Database. After screening the studies according to the inclusion and exclusion criteria, we summarized the neuroimaging mechanism of acupuncture on poststroke aphasia, as well as the utilization of acupuncture therapy and the methodological characteristics. Result. After searching, 885 articles were retrieved. After removing the literature studies, animal studies, and case reports, 16 studies were included in the final analysis. For the acupuncture type, 10 studies used manual acupuncture and 5 studies used electroacupuncture, while body acupuncture (10 studies), scalp acupuncture (7 studies), and tongue acupuncture (8 studies) were applied for poststroke aphasia patients. Based on blood oxygen level-dependent (BOLD) and diffusion tensor imaging (DTI) technologies, 4 neuroimaging analysis methods were used including amplitude of low-frequency fluctuation (ALFF), regional homogeneity (ReHo), seed-based analysis, and independent component analysis (ICA). Two studies reported the instant acupuncture effect, and 14 studies reported the constant acupuncture’s effect on poststroke aphasia patients. 5 studies analyzed the correlation between the neuroimaging outcomes and the clinical language scales. Conclusion. In this systematic review, we found that the mechanism of acupuncture’s effect might be associated with the activation and functional connectivity of language-related brain areas, such as brain areas around Broca’s area and Wernicke’s area in the left inferior temporal gyrus, supramarginal gyrus, middle frontal gyrus, and inferior frontal gyrus. However, these studies were still in the preliminary stage. Multicenter randomized controlled trials (RCT) with large sample sizes were needed to verify current evidence, as well as to explore deeply the neuroimaging mechanisms of acupuncture’s effects.

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Reversal of neurovascular coupling in the default mode network: Evidence from hypoxia

Cited by 20 publications

References 68 publications

The oxygen initial dip in the brain of anesthetized and awake mice

The oxygen initial dip in the brain of anesthetized and awake mice

Bilateral regional extracranial blood flow regulation to hypoxia and unilateral duplex ultrasound measurement error

Revealing the Neuroimaging Mechanism of Acupuncture for Poststroke Aphasia: A Systematic Review

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