Reversal of oxalosis cardiomyopathy after combined liver and kidney transplantation

Detry, Olivier; Honoré, Pierre; Deroover, Arnaud; Trimèche, Mounir; Demoulin, J. C.; Beaujean, M; Moonen, Martial; Godon, J. P.; Boniver, Jacques; Jacquet, Nicolas; Meurisse, Michel

doi:10.1007/s00147-001-0364-y

Cited by 20 publications

(17 citation statements)

References 9 publications

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“…33 While cardiac manifestations can be fatal, they are reversed following successful liver transplantation. 34–37 The true epidemiology of cardiac involvement is unknown and case reports are not ideal sources for best evidence. This is the first paper that systematically investigates cardiac abnormalities in a large population of PH from a single academic center over a 6 decade period.…”

Section: Discussionmentioning

confidence: 99%

Cardiac Abnormalities in Primary Hyperoxaluria

Mookadam

Smith

Jiamsripong

et al. 2010

Circ J

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Background In patients with primary hyperoxaluria (PH), oxalate overproduction can result in recurrent urolithiasis and nephrocalcinosis, which in some cases results in a progressive decline in renal function, oxalate retention, and systemic oxalosis involving bone, retina, arterial media, peripheral nerves, skin, and heart. Oxalosis involving the myocardium or conduction system can potentially lead to heart failure and fatal arrhythmias. Methods and Results A retrospective review of our institution’s database was conducted for all patients with a confirmed diagnosis of PH between 1/1948 and 1/2006 (n=103). Electrocardiogram (ECG) and echocardiography were used to identify cardiac abnormalities. Ninety-three patients fulfilled the inclusion criteria, 58% were male. Mean follow-up was 11.9 (median 8.8) years. In 38 patients who received an ECG or echocardiography, 31 were found to have any cardiac abnormalities. Cardiac findings correlated with decline in renal function. Conclusions Our data suggests that physicians caring for patients with PH should pay close attention to cardiac status, especially if renal function is impaired.

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Section: Discussionmentioning

confidence: 99%

Cardiac Abnormalities in Primary Hyperoxaluria

Mookadam

Smith

Jiamsripong

et al. 2010

Circ J

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“…The success of renal transplantation (RT) or LT depends on establishing effective clearance of oxalate from tissues often necessitating perioperative dialysis. Effective RT or LT may improve cardiac function, reduce myocardial oxalate deposits, and reduce mortality from end‐stage cardiomyopathy …”

Section: Inherited Metabolic Diseasementioning

confidence: 99%

“…Effective RT or LT may improve cardiac function, reduce myocardial oxalate deposits, and reduce mortality from end-stage cardiomyopathy. (46)…”

Section: Primary Hyperoxaluria Typementioning

confidence: 99%

Cardiac and Liver Disease in Children: Implications for Management Before and After Liver Transplantation

et al. 2019

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There is close interaction between the functions of the liver and heart affecting the presentation, diagnosis, and outcome of acute and chronic cardiac and liver disease. Conditions affecting both organ systems should be considered when proposing transplantation because the interaction between cardiac disease and liver disease has implications for diagnosis, management, selection for transplantation, and, ultimately, for longterm outcomes after liver transplantation (LT). The combination of cardiac and liver disease is well recognized in adults but is less appreciated in pediatric patients. The focus of this review is to describe conditions affecting both the liver and heart and how they affect selection and management of LT in the pediatric population.

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“…38 Combined liver and kidney transplantation has been shown to reverse cardiac dysfunction and oxalate deposits in the heart. 40 …”

Section: Extracardiac Infiltrative Cardiomyopathiesmentioning

confidence: 99%

Genetic Infiltrative Cardiomyopathies

Sweet

Mestroni

Taylor

2018

Heart Failure Clinics

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Reversal of oxalosis cardiomyopathy after combined liver and kidney transplantation

Abstract: Few data have been published on the course of oxalosis cardiomyopathy after combined liver and kidney transplantation in hyperoxaluria patients with

Cited by 20 publications

References 9 publications

Cardiac Abnormalities in Primary Hyperoxaluria

Cardiac Abnormalities in Primary Hyperoxaluria

Cardiac and Liver Disease in Children: Implications for Management Before and After Liver Transplantation

Genetic Infiltrative Cardiomyopathies

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