Reversal of Profound Neuromuscular Block by Sugammadex Administered Three Minutes after Rocuronium

Abstract

Reversal of profound high-dose rocuronium-induced neuromuscular block (1.2 mg/kg) with 16 mg/kg sugammadex was significantly faster than spontaneous recovery from 1 mg/kg succinylcholine.

Fibreoptic bronchoscopy to facilitate ProSeal laryngeal mask airway insertion in a patient with ankylosing spondylitis

“…The authors point out that in Lee et al's study [6], reversal to a T4 ⁄ T1 ratio of 0.9 would take a mean time of 2.2 min. The standard deviation was also 2.2 min, implying that many patients would take significantly longer.…”

“…This should help avoid unexpected trauma or accidental intratracheal placement. The Glidescope (Verathon Inc, Bothell, WA, USA) can assist nasogastric tube placement and PLMA insertion, but is difficult to use in patients with limited mouth opening [6]. The use of neuromuscular blocking agents to facilitate PLMA insertion is controversial in ankylosing spondylitis patients because of the presence of altered airway anatomy and restricted pulmonary function [7], although their use has been described [8].…”

Anaesthetic considerations for pectus repair surgery

“…Rocuronium (1-1.5 mg/kg) has a particular advantage of rapid onset, long effect, minimal histamine release and potential rapid reversal with sugammadex (47) in case of failure to intubate.…”

Post-Operative Residual Curarization (PORC): A Big Issue for Patients' Safety

“…The administration must be modified in patients with renal diseases, adjusting the dosage to the actual renal function. The security in dyalazed patients is limited and the use is not recommended in severe renal failure (creatinine clearance < 30 ml/min) (Abrishami et al, 2010;Della Rocca G et al, 2009;Duvaldestin P et al, 2009;Khuenl-Brady KS et al, 2010;Lee C et al, 2009;McDonagh DL et al, 2011;Plaud B et al, 2009;Schaller SJ et al, 2010;Staals LM et al, 2010;White PF et al,2009) …”