Reversal of Propylthiouracil Induced-Fetal Ascites in Monochorionic Twins

Abstract

ABS TRACT There are various causes in the etiology of fetal ascites and non-immune hydrops fetalis. Pathogenesis of non-immune hydrops fetalis is incompletely understood. The etiology cannot be determined in yet a large part of cases. Here we reported an isolated fetal ascites case in both fetuses, in a monochorionic pregnancy during maternal propylthiouracil (PTU) use. Fetal goiter was detected in both fetuses and after maternal oral tri-iodothyronine treatment, ascites resolved and babies were delivered at 36 th week of pregnancy. Anti-thyroid drugs (ATDs) should be used carefully during pregnancy. Fetal hypothyroidism may be associated with fetal hyrdrops. Maternal oral tri-iodothyronine administration may treat fetal hypothyroidism.