Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146

Norman, Bryan H.; Dantzig, Anne H.; Kroin, Julian S.; Law, Kenneth S.; Tabas, Linda B.; Shepard, Robert L.; Palkowitz, Alan D.; Hauser, Kenneth L.; Winter, Mark A.; Sluka, James P.; Starling, James J.

doi:10.1016/s0960-894x(99)00610-1

Cited by 28 publications

(13 citation statements)

References 11 publications

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“…In order to improve the response of tumor cells to chemotherapy, compounds have been developed to inhibit MRP1 activity in tumors (2). Because of the expression of MRP1 in normal tissues (3), one potential complication of this approach is the inhibition of MRP1 function in normal cells.…”

mentioning

confidence: 99%

Transport of Fluorescein in MDCKII-MRP1 Transfected Cells and mrp1-Knockout Mice

Sun

Johnson

Finch

et al. 2001

Biochemical and Biophysical Research Communications

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mentioning

confidence: 99%

Transport of Fluorescein in MDCKII-MRP1 Transfected Cells and mrp1-Knockout Mice

Sun

Johnson

Finch

et al. 2001

Biochemical and Biophysical Research Communications

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“…In addition, several highly specific ad potent MRP1 inhibitors have been identified. These include tricyclic isoxazole derivatives such as LY475776 and LY402913 (98)(99)(100). It has been reported that some antisense oligonucleotides are also able to inhibit MRP1 activity by reducing MRP1 mRNA levels and the protein synthesis (101)(102)(103).…”

Section: Substrate Specificity Resistance Profiles and Inhibitor Selmentioning

confidence: 99%

Role of Multidrug Resistance Associated Proteins in Drug Development

Zhou

2012

Multidrug Resistance: A Global Concern

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“…In addition, several highly specific ad potent MRP1 inhibitors have been identified. These include tricyclic isoxazole derivatives such as LY475776 and LY402913 [Norman et al, 1999;Mao et al, 2002;Qian et al, 2002]. It has been reported that some antisense oligonucleotides are also able to inhibit MRP1 activity by reducing MRP1 mRNA levels and the protein synthesis [Stewart et al, 1996;Niewiarowski et al, 2000;Peaston et al, 2001].…”

Section: Mrp1mentioning

confidence: 99%

Multidrug resistance proteins (MRPs) and implication in drug development

Tian

Zhang

Chan

et al. 2005

Drug Development Research

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The multidrug resistance protein (MRP)-related ABCC family (MRP1, MRP2, MRP3, MRP4, MRP5, MRP6, MRP7, MRP8, and MRP9) belongs to the ATP-binding cassette (ABC) superfamily of transport proteins. They are capable of transporting a structurally diverse array of endo-and xenobiotics and their metabolites across cell membranes. These transporters play an important role in the absorption, disposition, and elimination of these compounds in the body. In particular, increased expression of these drug transporters in tumor cells is associated with resistance to a number of important chemotherapeutic agents. This review highlights the biochemical and pharmacological properties of MRP1-9 and their implications in drug development. A detailed study on the biochemical function and regulation of MRPs is important in drug development, as this may help to avoid drug toxicity, drug resistance, and drug-drug interactions and to optimize cancer chemotherapy. Drug Dev. Res. 64:1-18, 2005.

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Reversal of resistance in multidrug resistance protein (MRP1)-overexpressing cells by LY329146

Cited by 28 publications

References 11 publications

Transport of Fluorescein in MDCKII-MRP1 Transfected Cells and mrp1-Knockout Mice

Transport of Fluorescein in MDCKII-MRP1 Transfected Cells and mrp1-Knockout Mice

Role of Multidrug Resistance Associated Proteins in Drug Development

Multidrug resistance proteins (MRPs) and implication in drug development

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