1953
DOI: 10.1038/172160a0
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Reversal of the Antibacterial Activity of Polymyxin by Divalent Cations

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Cited by 70 publications
(45 citation statements)
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“…Like the aminoglycosides, the effect seemed to be on the uptake of drug or on the interaction of the cations with the cell wall (2,12,13). In one report, the antagonistic effect was less than that observed with gentamicin (8), whereas in another it was greater (5), and in a third variable (3).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…Like the aminoglycosides, the effect seemed to be on the uptake of drug or on the interaction of the cations with the cell wall (2,12,13). In one report, the antagonistic effect was less than that observed with gentamicin (8), whereas in another it was greater (5), and in a third variable (3).…”
Section: Discussionmentioning
confidence: 99%
“…The antagonistic effect of divalent cations on the antibacterial activity of aminoglycosides (7), polymyxins (12), and tetracycline (18) has been recognized for many years. The largest number of reports (1, 3,5,8,9,11,15,19) have documented the marked effects of the calcium and magnesium content in broth media on the activity of gentamicin against Pseudomonas aeruginosa but not Enterobacteriaceae.…”
mentioning
confidence: 99%
“…However, a cation-dependent inhibition of antimicrobial activity has been reported for polymyxin antibiotics (90,91). In fact, it is suspected that the colistin antimicrobial activity might be overestimated if tested using conventional cation-adjusted MH as recommended by the CLSI.…”
Section: Impact Of Materials On Mic Determinationmentioning
confidence: 99%
“…The polar head and nonpolar fatty acid chain confer amphipathic properties which permit the polymyxins to interact with both lipopolysaccharides and phospholipids (18,36,37,48). Furthermore, polymyxins also interact electrostatically with membranes in the gram-negative cell envelope by competitively displacing divalent cations (e.g., calcium and magnesium) from the negatively charged phosphate groups of membrane lipids (26). Disruption of the divalent cation bridges and insertion of the cyclic ring (heptapeptide) into the membrane bilayer are likely to be responsible for the observed destabilization of membrane integrity induced by polymyxins (36).…”
mentioning
confidence: 99%