Reverse engineering of Perseris and development of compositionally equivalent formulations

Wang, Xiaoyi; Bao, Quanying; Wang, Ruifeng; Wan, Bo; Wang, Yan; Qin, Bin; Burgess, Diane J.

doi:10.1016/j.ijpharm.2023.122948

Cited by 8 publications

(1 citation statement)

References 22 publications

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“…Introducing more LAI formulations requires a better understanding of the mechanisms of drug loading and release from LAI formulations. Recent studies on PLGA formulations initiated by the FDA have produced a wealth of information on the nature of PLGA polymers, the impact of PLGA polymer types on the drug releaser properties, the impact of processing parameters on the drug release kinetics, and reverse engineering. − …”

Section: Future Ddssmentioning

confidence: 99%

Bohemian Rhapsody of Future Drug Delivery Systems: Rational Changes Necessary for the Next Revolution

Park,

Otte,

2024

Mol. Pharmaceutics

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Controlled drug delivery technology has matured for more than 70 years, starting from a twice-a-day oral formulation to 6 month long-acting injectable formulations. Further technological advances require superior formulations to treat various diseases more efficiently. Developing future formulations with practical innovations for treating existing and new diseases necessitates our continued efforts to overcome at least three main hurdles. They include (i) drug delivery with reduced side effects, (ii) long-term treatment of chronic diseases, and (iii) the overcoming of biological barriers. Such efforts start with the improved ability to accurately test drug delivery efficacy using proper controls. Future development can be aided by artificial intelligence if used properly. The next revolution of drug delivery systems will be augmented if implementation is given equal weight as discovery. Such a process can be accelerated with the systemic revamp of the research funding structure and cultivating a new generation of scientists who can think differently.

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