Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease

Heidari, Laleh; Ghaderian, Sayyed Mohammad Hossein; Bastami, Milad; Hosseini, Shadi; Parsa, Saeed; Heidari, Samaneh; Jafari, Hossein; Sohrabifar, Nasim; Pirhoushiaran, Maryam

doi:10.1080/13813455.2020.1797100

“…Epidemiological studies have suggested that genetic SIRT1 polymorphisms are associated with the risk of CAD, 563 while the expression level of SIRT1 is reduced in CAD patients. 564 SIRT1 inhibition causes oxidative stress and inflammation in CAD patients. 565 On a molecular level, expression of downregulated SIRT1 in human CAD monocytes is related to the enhanced acetylated p53 expression levels.…”

Section: Discussionmentioning

confidence: 99%

The sirtuin family in health and disease

Wu

¹

,

Zhang

²

,

Chen

³

et al. 2022

Sig Transduct Target Ther

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Sirtuins (SIRTs) are nicotine adenine dinucleotide(+)-dependent histone deacetylases regulating critical signaling pathways in prokaryotes and eukaryotes, and are involved in numerous biological processes. Currently, seven mammalian homologs of yeast Sir2 named SIRT1 to SIRT7 have been identified. Increasing evidence has suggested the vital roles of seven members of the SIRT family in health and disease conditions. Notably, this protein family plays a variety of important roles in cellular biology such as inflammation, metabolism, oxidative stress, and apoptosis, etc., thus, it is considered a potential therapeutic target for different kinds of pathologies including cancer, cardiovascular disease, respiratory disease, and other conditions. Moreover, identification of SIRT modulators and exploring the functions of these different modulators have prompted increased efforts to discover new small molecules, which can modify SIRT activity. Furthermore, several randomized controlled trials have indicated that different interventions might affect the expression of SIRT protein in human samples, and supplementation of SIRT modulators might have diverse impact on physiological function in different participants. In this review, we introduce the history and structure of the SIRT protein family, discuss the molecular mechanisms and biological functions of seven members of the SIRT protein family, elaborate on the regulatory roles of SIRTs in human disease, summarize SIRT inhibitors and activators, and review related clinical studies.

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“…Studies have shown that SIRT1 deficiency contributed to increased inflammation, oxidative stress, foam cell formation, impaired nitric oxide (NO) production, and autophagy, thereby promoting vascular atherosclerosis [18], which is an important risk factor for CAD. One recent study by Ghaderian et al [19] has shown that SIRT1 mRNA expression levels decreased in CAD patients with or without diabetes. This finding was consistent with an investigation that evaluated the protective effect of SIRT1 in predisposing CAD [13], showing that the expression of SIRT1 mRNA in patients with CAD decreased compared with controls.…”

Section: Discussionmentioning

confidence: 99%

“…Rs7069102 was the most widely studied member of SIRT1 gene. Results from different research groups have demonstrated that rs7069102 was associated with the CAD risk; the G allele may increase CAD risk, but C allele may be protective against CAD [19,21]. Potential mechanisms of rs7069102 were associated with the decreased expression of SIRT1, which may contribute to the CAD development through decreased ROS production.…”

Section: Discussionmentioning

confidence: 99%

Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population

Song

¹

,

Wang

²

,

Wang

³

et al. 2022

BioMed Research International

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Aims. Coronary artery disease (CAD) represents the leading cause of death worldwide. Accumulating evidence also suggests that sirtuins (SIRTS) have been associated with CAD. The present study was aimed at investigating the association between 12 gene polymorphisms for SIRTs and the development of CAD in a Chinese population. Materials and Methods. 12 SNPs (rs12778366 ( T > C ), rs3758391 ( T > C ), rs3740051 ( A > G ), rs4746720 ( C > T ), rs7895833 ( G > A ), rs932658 ( A > C ) for SIRT1, rs2015 ( G > T ) for SIRT2, rs28365927 ( G > A ), rs11246020 ( C > T ) for SIRT3, rs350844 ( G > A ), rs350846 ( G > C ), and rs107251 ( C > T ) for SIRT6) were selected and assessed in a cohort of 509 CAD patients and 552 matched healthy controls for this study. Genomic DNA from whole blood was extracted, and the SNPs were assessed using MassARRAY method. Results. TT genotype for rs3758391 and GG genotype for rs7895833 of SIRT1 were at higher risk of CAD, whereas the CC genotype for rs4746720 of SIRT1 was associated with a significantly decreased risk of CAD. The A allele of the rs28365927 of SIRT3 showed a significant decreased risk association with CAD patient group ( P = 0.014 ). Significant difference in genotypes rs350844 ( G > A ) ( P = 0.004 ), rs350846 ( G > C ) ( P = 0.002 ), and rs107251 ( C > T ) ( P ≤ 0.01 ) for SIRT6 was also found between the CAD patients and the healthy controls. Haplotype CTA significantly increased the risk of CAD ( P = 0.000118 , OR = 1.497 , 95 % CI = 1.218 – 1.840 ), while haplotype GCG significantly decreases the risk of CAD ( P = 0.000414 , OR = 1.131 , 95 % CI = 0.791 – 1.619 ). Conclusions. The SNP rs28365927 in the SIRT3 gene and SNP rs350844, rs350846, and rs107251 in the SIRT6 gene present significant associations with CAD in a north Chinese population. Haplotype CTA and GCG generated by rs350846/rs107251/rs350844 in the SIRT6 might also increase and decrease the risk of CAD, respectively.

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“…BIRC2 expression is downregulated by promoter hypermethylation ( 49 , 50 ), which was also associated with increased IL-1β production ( 49 , 51 ). Similarly, hypermethylation of the SIRT1 gene (encoding the Sirtuin 1, a deacetylase whose downregulation has been found in many disease conditions) correlates with lower transcript levels and with an increased risk of inflammatory and metabolic diseases ( 52 , 53 ). SIRT1 affects multiple biological processes by de-acetylating a variety of proteins including histones and non-histone proteins.…”

Section: Discussionmentioning

confidence: 99%

Association between night shift work and methylation of a subset of immune-related genes

Ferrari

¹

,

Monti²,

Favero³

et al. 2023

Front. Public Health

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IntroductionNight shift (NS) work has been associated with an increased risk of different conditions characterized by altered inflammatory and immune responses, such as cardio-metabolic and infectious diseases, cancer, and obesity. Epigenetic modifications, such as DNA methylation, might mirror alterations in biological processes that are influenced by NS work.MethodsThe present study was conducted on 94 healthy female workers with different working schedules and aimed at identifying whether NS was associated with plasmatic concentrations of the inflammatory proteins NLRP3 and TNF-alpha, as well as with DNA methylation levels of ten human endogenous retroviral (HERV) sequences, and nine genes selected for their role in immune and inflammatory processes. We also explored the possible role of the body mass index (BMI) as an additional susceptibility factor that might influence the effects of NS work on the tested epigenetic modifications.Results and discussionWe observed a positive association between NS and NLRP3 levels (p-value 0.0379). Moreover, NS workers retained different methylation levels for ERVFRD-1 (p-value = 0.0274), HERV-L (p-value = 0.0377), and HERV-P (p-value = 0.0140) elements, and for BIRC2 (p-value = 0.0460), FLRT3 (p-value = 0.0422), MIG6 (p-value = 0.0085), and SIRT1 (p-value = 0.0497) genes. We also observed that the BMI modified the relationship between NS and the methylation of ERVE, HERV-L, and ERVW-1 elements. Overall, our results suggest that HERV methylation could pose as a promising biomolecular sensor to monitor not only the effect of NS work but also the cumulative effect of multiple stressors.

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Reverse expression pattern of sirtuin-1 and histone deacetylase-9 in coronary artery disease

Cited by 9 publications

References 34 publications

The sirtuin family in health and disease

The sirtuin family in health and disease

Association of Sirtuin Gene Polymorphisms with Susceptibility to Coronary Artery Disease in a North Chinese Population

Association between night shift work and methylation of a subset of immune-related genes

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