Reverse-Micelle Synthesis of Electrochemically Encoded Quantum Dot Barcodes: Application to Electronic Coding of a Cancer Marker

Xiang, Yun; Zhang, Yuyong; Chang, Yue; Chai, Yaqin; Wang, Joseph; Yuan, Ruo

doi:10.1021/ac902335e

Cited by 40 publications

(23 citation statements)

References 25 publications

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“…Xiang et al. were the first authors describing the preparation of electrochemically‐encoded QD barcodes using a reverse‐micelle system. The procedure consisted of adding either Pb 2+ ‐Cd 2+ or Zn 2+ ‐Cd 2+ ‐Pb 2+ containing micellar solutions to a S 2− containing micellar solution under a nitrogen environment.…”

Section: Metallic Qds As Signal Amplifiers In the Detection Of Clinimentioning

confidence: 99%

Electrochemical (Bio)sensing of Clinical Markers Using Quantum Dots

2016

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Quantum dots (QDs) are a kind of semiconductor nanoparticles with great potential in (bio)sensing for medical diagnosis due not only to their optical properties but also to their applicability in the development of electrochemical (bio)sensors. In this article, the use of metallic and graphene QDs for electrochemical signal amplification, either as signal tags or as electrode surface modifiers to detect clinical markers is reviewed and critically discussed. The advantages and disadvantages arising from the use of these nanoparticles in this context will be outlined together with the still required work to fulfil the characteristics needed to attain suitable electrochemical (bio)sensors with real application in clinical field.

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Section: Metallic Qds As Signal Amplifiers In the Detection Of Clinimentioning

confidence: 99%

Electrochemical (Bio)sensing of Clinical Markers Using Quantum Dots

2016

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“…Using biocatalysts to generate barcodes provides an interesting mechanism of encryption processing that is based entirely on the catalytic mechanism of an enzyme. Not all examples of unconventional bar codes employ biogenerated digital sequences [40][41][42][43][44][45][46][47]; encryption tags, for example, are fabricated from specific alignment of metallic nanowires and quantum dots [40,41]. These types of unconventional barcodes include medical diagnostic models and multiplexed bioanalytical assays that can detect single proteins or single molecules of DNA [41][42][43][44]46].…”

Section: Bio-barcodementioning

confidence: 99%

Information Security Applications Based on Biomolecular Systems

Strack

Luckarift

Johnson³

et al. 2012

Biomolecular Information Processing

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IntroductionModern computers rely on networked logic gates performing Boolean operations to carry out binary computational functions. By extending the same digital paradigms to molecular [1][2][3][4] and biomolecular computing systems [5,6], chemical processes can mimic electronic counterparts and perform logic operations. For example, Boolean logic gates such as AND, OR, XOR, NOR, NAND, and INHIB, have been demonstrated based on switchable molecular systems [1][2][3][4]. In addition, a wide range of biomolecules have been used for information processing [5,6]. The simplicity of biomolecular processing is attributed to the inherent substrate specificity and versatility of biomolecules; thus the application of biomolecular systems for processing chemical and biochemical information has reached high levels of complexity, despite employing only simple chemical signals.Compared to the advanced power and complexity of computing performed in silico, molecular and biomolecular computing is primitive; however, biomolecular information processing has a niche application in small portable devices that rely on a specific bioelectronic interface. In this area of technological development, portable biomedical sensors [7] with built-in diagnostic capabilities and controlled by simple biomolecular logic operations can be realized [8][9][10][11].Despite significant advances in DNA-based computing [12][13][14], examples of enzyme-based computing are sparse, but the inherent advantage that enzymes exhibit over DNA is catalytic specificity. To date, enzyme-based logic gates using chemical inputs have been demonstrated for XOR, INHIBIT A, INHIBIT B, AND, OR, NOR, Identity, and Inverter Boolean operators [15,16]. These single logic gates all operate as independent systems, that is, the output does not act as an input for a subsequent logic operation. In contrast, biocatalytic logic systems with increased complexity can be designed by defining specific reaction cascades [17]. In fact, biocatalytic cascades found in Nature provide insight into engineering such systems. Thus, by combining enzymes with interconnected and compatible reactions, Baron et al. [16] have demonstrated half-adder and Biomolecular Information Processing: From Logic Systems to Smart Sensors and Actuators, First Edition. Edited by Evgeny Katz.

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“…Simultaneous detection of multiple DNA, based on various semiconductor nanoparticle compositions, has also been developed by Wang ' s group [18,22] . The multitarget electrical DNA detection system based on different nanoparticles is shown in Figure 10.18 [18] .…”

Section: Quantum Dot -Based Electrochemical Biosensors Of Proteins Anmentioning

confidence: 99%

“…The device has been successfully applied for the detection of prostate -specifi c antigen in human serum samples with a detection limit of 20 pg ml − 1 . Recently, Wang ' s group reported the QD barcode made by the reverse micelle synthesis method for the electrochemical determination of a cancer marker ( carcinoembryonic antigen ( CEA )) [22] . The electrochemical stripping response of the dissolved CdS/PbS barcode shows a linear range for the logarithmic concentration of CEA from 0.01 to 80 ng ml − 1 , with an estimated detection limit of 3.3 pg ml − 1 .…”

Section: Quantum Dot -Based Electrochemical Biosensors Of Proteins Anmentioning

confidence: 99%

Semiconductor Quantum Dots for Electrochemical Biosensors

Wang

Knudsen

Zhang

2011

Biosensor Nanomaterials

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IntroductionQuantum dot s ( QD s) or semiconductor nanoparticles are colloidal nanocrystalline semiconductors made of group II -VI or III -V elements. With diameters of between 1 and 100 nm, QDs demonstrate interesting optical and electronic properties. The unique photophysical properties of QDs, such as high fl uorescence, quantum yield stability against photobleaching, and size -controlled luminescence properties, enable them to be utilized as optical labels for bioanalysis [1] . The photoexcitation of semiconductor QDs can result in the transfer of an electron from the valence band to the conduction band, thus yielding an electron hole pair. When the photoexcited QDs were confi ned to electrode surfaces, the cathodic photocurrent could be formed by the ejection of the conduction band electrons to an electron acceptor in the electrolyte solution, followed by the supply of electrons from the electrode to neutralize the valence -bound holes. By comparison, the anodic photocurrent can be yielded by transferring the conduction band electrons to the electrode with the transfer of electrons from an electron donor in the solution [2] . These photoelectrochemical properties of QDs can be used for developing light -to -electrical energy conversion systems. The optical and electrophotochemical applications of QDs for bioanalysis were reviewed by Zayats and Willner [2] .It is known that the surfaces of QDs can be chemically modifi ed by a functional capping monolayer, which allows a tethering of the biomacromolecules for bioanalysis applications [3] . When biomacromolecules are immobilized on the surface of QDs, the semiconductor QDs also can promote direct electron transfer between the biomolecules and electrode surface, and improve the performance of the biosensor. Recently, QDs were incorporated with redox proteins by covalent bonding or electrostatic interaction to realize the direct electrochemistry of the biosensor. Electrochemical immunosensors or immunoassays for DNA and proteins have developed dramatically over the past two decades because of their high sensitivity, inherent simplicity, low cost, and miniaturization. Nanomaterials -based electrochemical immunoassays and immunosensors have attracted considerable interest, since they can enhance the sensitivity via the signal amplifi cation. Of the various

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Reverse-Micelle Synthesis of Electrochemically Encoded Quantum Dot Barcodes: Application to Electronic Coding of a Cancer Marker

Cited by 40 publications

References 25 publications

Electrochemical (Bio)sensing of Clinical Markers Using Quantum Dots

Electrochemical (Bio)sensing of Clinical Markers Using Quantum Dots

Information Security Applications Based on Biomolecular Systems

Semiconductor Quantum Dots for Electrochemical Biosensors

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