Reverse remodeling and enhancedadrenergic reserve from passive externalsupport in experimental dilated heart failure

Saavedra, Walter F.; Tunin, Richard S.; Paolocci, Nazareno; Mishima, Takayuki; Suzuki, George; Emala, Charles W.; Chaudhry, Pervaiz A; Anagnostopoulos, Petros V.; Gupta, Ramesh C.; Sabbah, Hani N.; Kass, David A.

doi:10.1016/s0735-1097(02)01890-9

Cited by 115 publications

(80 citation statements)

References 38 publications

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“…Porcine and ovine models are characterized by predictable infarction sizes and closely mimic ischemic cardiomyopathy in humans. 105,110 Coronary Microembolization Serial left coronary artery microembolization with polystyrene microspheres has been used to induce dilated ischemic cardiomyopathy in dogs [115][116][117] and sheep. 118 -120 Acutely microembolized myocardium exhibits contractile dysfunction with a profound perfusion-contraction mismatch, and localized inflammatory responses and TNF expression, as well.…”

Section: Large-animal Dcm Modelsmentioning

confidence: 99%

Animal Models of Heart Failure

Houser¹,

Margulies²,

Murphy³

et al. 2012

Circulation Research

387

223

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Section: Large-animal Dcm Modelsmentioning

confidence: 99%

Animal Models of Heart Failure

Houser¹,

Margulies²,

Murphy³

et al. 2012

Circulation Research

387

223

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“…[1][2][3][4][5][6][7][8]20,21 To date, no study has evaluated LV mechanics in restraint or the effect of adjustable restraint. Current ventricular restraint techniques, such as the Acorn Cardiac Support Device (Acorn Cardiovascular, St. Paul, Minn) and the Paracor (Paracor Medical Systems, Sunnyvale, Calif), do not allow for either the quantitative adjustment of restraint level or the measurement of P tm .…”

Section: Discussionmentioning

confidence: 99%

“…In comparison, Saveedra et al found a 19Ϯ4% reduction in LV EDV over 6 months in a canine model of HF that used the Acorn Cardiac Support Device. 8 Other studies in animal models demonstrated prevention rather than reversal of LV dilation. 5,6 In human studies, modest improvements in LV EDV have been found.…”

Section: Discussionmentioning

confidence: 99%

“…Numerous studies have demonstrated that passive ventricular restraint may prevent or reverse left ventricular (LV) dilation and remodeling in HF. [3][4][5][6][7][8] The precise mechanics of this, however, are not known. Our hypothesis is that ventricular restraint decreases transmural myocardial pressure (P tm ) by pressure application on the epicardium at end diastole.…”

mentioning

confidence: 99%

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Adjustable, Physiological Ventricular Restraint Improves Left Ventricular Mechanics and Reduces Dilatation in an Ovine Model of Chronic Heart Failure

et al. 2007

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Background-Ventricular restraint is a nontransplantation surgical treatment for heart failure. The effect of varying restraint level on left ventricular (LV) mechanics and remodeling is not known. We hypothesized that restraint level may affect therapy efficacy. Methods and Results-We studied the immediate effect of varying restraint levels in an ovine heart failure model. We then studied the long-term effect of restraint applied over a 2-month period. Restraint level was quantified by use of fluid-filled epicardial balloons placed around the ventricles and measurement of balloon luminal pressure at end diastole. At 4 different restraint levels (0, 3, 5, and 8 mm Hg), transmural myocardial pressure (P tm ) and indices of myocardial oxygen consumption (MV O 2 ) were determined in control (nϭ5) and ovine heart failure (nϭ5). Ventricular restraint therapy decreased P tm and MV O 2 , and improved mechanical efficiency. An optimal physiological restraint level of 3 mm Hg was identified to maximize improvement without an adverse affect on systemic hemodynamics. At this optimal level, end-diastolic P tm and MV O 2 indices decreased by 27% and 20%, respectively. The serial longitudinal effects of optimized ventricular restraint were then evaluated in ovine heart failure with (nϭ3) and without (nϭ3) restraint over 2 months. Optimized ventricular restraint prevented and reversed pathological LV dilatation (130Ϯ22 mL to 91Ϯ18 mL) and improved LV ejection fraction (27Ϯ3% to 43Ϯ5%). Measured restraint level decreased over time as the LV became smaller, and reverse remodeling slowed. Conclusions-Ventricular restraint level affects the degree of decrease in P tm , the degree of decrease in MV O 2 , and the rate of LV reverse remodeling. Periodic physiological adjustments of restraint level may be required for optimal restraint therapy efficacy.

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“…The large animal acute coronary occlusion model can be accomplished via embolization, 129,130 microspheres, 131 balloon, 132 and ligation. [118][119][120] Canine, ovine, and porcine models are described extensively in the literature.…”

Section: Acute Coronary Occlusion Modelsmentioning

confidence: 99%

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization

Simons¹,

Alitalo²,

Annex³

et al. 2015

Circulation Research

114

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Reverse remodeling and enhancedadrenergic reserve from passive externalsupport in experimental dilated heart failure

Abstract: Reverse remodeling with reduced systolic wall stress and improved adrenergic signaling can be achieved by passive external support that does not generate diastolic constriction. This approach may prove useful in the treatment of chronic heart failure.

Cited by 115 publications

References 38 publications

Animal Models of Heart Failure

Animal Models of Heart Failure

Adjustable, Physiological Ventricular Restraint Improves Left Ventricular Mechanics and Reduces Dilatation in an Ovine Model of Chronic Heart Failure

State-of-the-Art Methods for Evaluation of Angiogenesis and Tissue Vascularization

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