Reverse Transcription Loop-Mediated Isothermal Amplification Assay-Based Infection Control Strategies for COVID-19 in a Hospital Under the State of Emergency in Tokyo, Japan in Spring 2020

Kimura, Muneyoshi; Baba, Masaru; Maruyama, Shunichiro; Ogura, Sho; Yamamuro, Ryosuke; Sakoh, Takashi; Kishida, Toshiyuki; Nagamine, Yumi; Endo, Yusuke; Okada, Chikako; Takahashi, Namiko; Araoka, Hideki

doi:10.7883/yoken.jjid.2020.808

Cited by 1 publication

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“…Due to supply problems of reagents, nasopharyngeal swabs collected between December 3, 2020 and February 16, 2021 were tested in the hospital using RT-LAMP according to previous studies [ 11 , 12 ], and nasopharyngeal swabs collected between February 16, 2021 and March 20, 2021 were tested using RT-qPCR. In all periods, RT-qPCR was used to test sputum in an external laboratory.…”

Section: Methodsmentioning

confidence: 99%

Universal admission screening for COVID-19 using quantitative antigen testing and questionnaire screening to prevent nosocomial spread

Morishima

Kimura²,

Sakoh³

et al. 2022

PLoS ONE

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Background In this study, we investigated diagnostic accuracy of quantitative severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antigen testing and whether universal screening was effective to prevent a nosocomial outbreak of coronavirus disease 2019 (COVID-19). Methods All adult patients admitted to an acute-care hospital in Tokyo, Japan, after receiving LUMIPULSE SARS-CoV-2 Ag using a nasopharyngeal swab and a brief questionnaire to evaluate symptoms and exposures from December 3, 2020 to March 20, 2021 were included. Results Of the 5191 patients, 53 were antigen-positive, 19 were inconclusive and 5119 were negative. The sensitivity and specificity (positive or inconclusive results) of the quantitative antigen test for COVID-19 diagnosis at admission was 0.957 (95% confidence interval [CI]: 0.855–0.995) and 0.995 (95% CI: 0.992–0.997), respectively. Six asymptomatic patients were identified on admission. Two patients were antigen-negative and diagnosed with COVID-19 later; however, they had been isolated prior to diagnosis because both had symptoms of COVID-19 and exposure. No nosocomial infections occurred during the period. Conclusion Quantitative SARS-CoV-2 antigen testing was found to be valid for the early detection of asymptomatic COVID-19 patients as a universal screening test on admission.

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Section: Methodsmentioning

confidence: 99%

Universal admission screening for COVID-19 using quantitative antigen testing and questionnaire screening to prevent nosocomial spread

Morishima

Kimura²,

Sakoh³

et al. 2022

PLoS ONE

Self Cite

View full text Add to dashboard Cite

show abstract

Reverse Transcription Loop-Mediated Isothermal Amplification Assay-Based Infection Control Strategies for COVID-19 in a Hospital Under the State of Emergency in Tokyo, Japan in Spring 2020

Abstract: Japanese Journal of Infectious Diseases Reverse transcription loop-mediated isothermal amplification assay-based infection control strategies for COVID-19 in a hospital under the state of emergency declaration in Tokyo, Japan in spring 2020

Cited by 1 publication

References 13 publications

Universal admission screening for COVID-19 using quantitative antigen testing and questionnaire screening to prevent nosocomial spread

Universal admission screening for COVID-19 using quantitative antigen testing and questionnaire screening to prevent nosocomial spread

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