Reversed cerebral asymmetry in women with breast cancer

Sandson, Thomas A.; Wen, Patrick Y.; LeMay, Marjorie

doi:10.1016/0140-6736(92)90341-y

Cited by 55 publications

(28 citation statements)

References 10 publications

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“…Among adult-onset cancers, the data are stronger with respect to breast cancer: the evidence comes from studies showing a positive association of birth size indicators with both breast cancer itself and high-risk mammograms (Ekbom et al, , 1997 a All differences between sites at each visit were statistically significant (P<0.05). Michels et al, 1996;Sanderson et al, 1996), findings which suggest that the excess risk for breast cancer is higher when a sister rather than the mother is affected among first-degree relatives (Eby et al, 1994;Bernstein et al, 1995;Hunter et al, 1997), investigations linking cerebral asymmetry to breast cancer risk (Sandson et al, 1992), and data indicating that pregnancy toxaemia is inversely and neonatal jaundice is positively associated with breast cancer risk in the offspring (Ekbom et al, 1997).…”

Section: Discussionmentioning

confidence: 99%

“…These characteristics include cerebral asymmetry that is believed to be conditioned by endocrine factors during the perinatal period (Sandson et al, 1992), birthweight which is likely to be affected by growth factors and perhaps exogenous influences (Michels et al, 1996;Sanderson et al, 1996;Ekbom et al, 1997), neonatal jaundice of unspecified aetiology (Ekbom et al, 1997) and, inversely, pregnancy toxaemia that is associated with profound but poorly understood endocrine changes (Ekbom et al, 1997). Although the dynamics of the intrauterine environment are clearly complex, hormones are central to its definition and notably oestrogens are necessary for the normal development of the breast.…”

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confidence: 99%

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Maternal pregnancy hormone levels in an area with a high incidence (Boston, USA) and in an area with a low incidence (Shanghai, China) of breast cancer

et al. 1998

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Summary Characteristics probably associated with the fetal hormonal milieu have recently been shown to increase (birth size indicators, prematurity, neonatal jaundice) or decrease (pregnancy toxaemia) breast cancer risk in the female offspring. However, it is unknown whether differences in pregnancy hormone levels may contribute to the marked geographical variation in breast cancer incidence. We have compared, in a highly standardized manner, pregnancy hormone levels in a population with high incidence and one with low incidence of breast cancer. Three hundred and four pregnant Caucasian women in Boston and 334 pregnant Chinese women in Shanghai were enrolled from March 1994 to October 1995. Levels of oestradiol, oestriol, prolactin, progesterone, human growth hormone, albumin and sex hormone-binding globulin were measured in maternal blood at weeks 16 and 27 of gestation and compared between the two study sites using non-parametric Wilcoxon's rank-sum test. Demographical, anthropometrical and pregnancy characteristics were ascertained through interview, and relevant variables concerning delivery and the newborn were abstracted from medical records and paediatric charts. During the first visit, median serum levels of all studied hormones were statistically significant, and in most instances substantially, higher among Chinese women, who have a low incidence of breast cancer, compared with American women, who have a high incidence of breast cancer. An analogous pattern was evident during the second visit, although the relative differences tended to be smaller. Further research is needed to identify lifestyle or other exogenous determinants of pregnancy hormone levels, as well as possible mechanisms by which they may influence carcinogenic processes in the breast and possibly other organs.

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Section: Discussionmentioning

confidence: 99%

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confidence: 99%

Maternal pregnancy hormone levels in an area with a high incidence (Boston, USA) and in an area with a low incidence (Shanghai, China) of breast cancer

et al. 1998

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“…This hypothesis was directly supported by two investigations Sandson et al, 1992). Further, highermaternal age at birth (Thompson & Janerich, 1990), being first-born (Hsieh et al, 1991) and being a twin are associated with increased breast cancer risk and also with increased kvels of pregnancy oestrogens (TambyRaja & Ratnam, 1981;Bernstein et al, 1986;Panagiotopoulou et al, 1990).…”

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confidence: 81%

Season of birth and breast cancer risk in Sweden

Yuen

Ekbom²,

Trichopoulos³

et al. 1994

Br J Cancer

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' (Miller, 1993). We here present evidence that season of birth is a determinant of breast cancer risk. Without addressing the pregnancy oestrogen hypothesis, birth seasonality would suggest perinatal influences. Our examination was prompted by the realisation that the food supply in Sweden must have had a more seasonal variation at the beginning of the century than it does today, owing to poorer food preservation and handling methods. Pates amid mtho"Since I January 1958 all newly diagnosed malignant tumours in Sweden must be reported to the National Cancer Registry by both the physician who makes the diagnosis and the confirming pathologist or cytologist (The Cancr Registry 1960-92). At the time of this study the Registry was complete up to 31 December 1989. We used information on site of the tumour, the birth date portion of the patient's national registration number and the year of diagnosis. Through the Registry, we identified all females reported with a first invasive breast cancer code by 12 months). Each patient was assigned to one of these cells based on her year and month of birth. Poisson regression models (Prener & Carstensen, 1990) were used to examine the data for seasonality using the log (number of births) in the multiplicative model. Idependent variables in the regression models included the decade effects (DEC), month as a categorical variable (MO) and month as a continuous variable (NMO). Monthwas also transformed by calulating sin (month x x/6) and cos (month x :/6) (SMO and CMO respectively) to explore the possibility of yearly cycles within the data. Likelihood ratio statstics were used to compare candidate models, and individual regression parameters were evaluated with 95% confidence intervals.We also considered whether childrn born in particular months or seasons might have a higher probability of survival until adulthood. To assess this possibilty we studied the birth seasonality among 466,336 women with cancer at sites other than the breast in the same database, again adjusting for seasonality of live births in the underlying population at risk. (Table II). The natural logarithm of the relative risk for breast cancer increased to a peak in June, and then decreased (Table EIl). No pattern was present in the data for cancers at all other sites. These models fit the data poorly (Table H, model B). This poor fit was due to a strong intraction between month and decade for both breast cancer and cancer at other sites. The addition of an intraction term of month as a continuous variable with decade to a model with only decade was highly significant for breast cancer (LRT = 59.09, 9 d.f.) and for all other cancers (122.8, 9 d.f.), indicating that the linear effect of month varied with decade (Table H, model C). The effect of month (continuous) was positive for the earlier decades (increasing risk through the year), but steadily decreased and was negative for later deades. Thebinteraction of month (categorical) with decade was not fitted, since this is a saturated model and would have le...

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“…The most discussed, but still unsolved question, is whether left-handed women are predisposed to breast cancer [62][63][64][65][66]. In some publications a higher frequency of left-handedness has been reported in breast cancer patients.…”

Section: Handedness-related Differencesmentioning

confidence: 99%

Brain asymmetry, immunity, handedness

et al. 2011

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AbstractThe principle of symmetry-asymmetry is widely presented in the structural and functional organization of the nonliving and living nature. One of the most complex manifestations of this principle is the left-right asymmetry of the human brain. The present review summarizes previous and contemporary literary data regarding the role of brain asymmetry in neuroimmunomodulation. Some handedness-related peculiarities are outlined additionally. Brain asymmetry is considered to be imprinted in the formation and regulation of the individual’s responses and relationships at an immunological level with the external and internal environment. The assumptions that the hemispheres modulate immune response in an asymmetric manner have been confirmed in experiments on animals. Some authors assume that the right hemisphere plays an indirect role in neuroimmunomodulation, controlling and suppressing the left hemispheric inductive signals.

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Reversed cerebral asymmetry in women with breast cancer

Cited by 55 publications

References 10 publications

Maternal pregnancy hormone levels in an area with a high incidence (Boston, USA) and in an area with a low incidence (Shanghai, China) of breast cancer

Maternal pregnancy hormone levels in an area with a high incidence (Boston, USA) and in an area with a low incidence (Shanghai, China) of breast cancer

Season of birth and breast cancer risk in Sweden

Brain asymmetry, immunity, handedness

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