Reversed-phase dispersive liquid–liquid microextraction with central composite design optimization for preconcentration and HPLC determination of oleuropein

Hashemi, Payman; Raeisi, Fatemeh; Ghiasvand, Alireza; Rahimi, Akram

doi:10.1016/j.talanta.2009.10.051

Cited by 83 publications

(33 citation statements)

References 22 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The principles of DLLME can also be exploited for the extraction of target compounds from M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 12 hydrophobic samples by using a hydrophilic solvent as extractant phase and a disperser solvent. This approach, termed as reversed-dispersive liquid-liquid microextraction (R-DLLME), was introduced by Hashemi et al in 2010 [50].…”

Section: Dispersive Liquid-liquid Microextraction and Related Techniquesmentioning

confidence: 99%

Liquid-phase microextraction combined with graphite furnace atomic absorption spectrometry: A review

Calle

Pena‐Pereira

Lavilla

et al. 2016

Analytica Chimica Acta

View full text Add to dashboard Cite

Section: Dispersive Liquid-liquid Microextraction and Related Techniquesmentioning

confidence: 99%

Liquid-phase microextraction combined with graphite furnace atomic absorption spectrometry: A review

Calle

Pena‐Pereira

Lavilla

et al. 2016

Analytica Chimica Acta

View full text Add to dashboard Cite

“…For reverse-phase DLLME, major criteria in the selection of extractant are (1) compatibility of the solvent with LC-MS/ MS, (2) greater solubility of the analytes in the solvent than in the organic solvent, and (3) the solvent should be immiscible with the organic solvent [28,40,41]. In this study, aqueous formic acid was used as the extraction solvent.…”

Section: Effect Of Extraction Solvent and Extraction Volumementioning

confidence: 99%

“…Therefore, it has attracted increasing attention. LPME can be divided into three main methodologies: single-drop microextraction (SDME) [24,25], hollow fiber-liquid-phase microextraction (HF-LPME) [26,27], and dispersive liquid-liquid microextraction (DLLME) [28][29][30]. SDME shows some difficulties in maintaining the stability of the hanged microdroplet in a stirred solution.…”

Section: Introductionmentioning

confidence: 99%

Development, validation, and application of a liquid chromatography–tandem mass spectrometry method for the determination of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human hair

Yang

Guan

et al. 2012

Anal Bioanal Chem

View full text Add to dashboard Cite

The tobacco-specific nitrosamine metabolite 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol (NNAL) is a valuable biomarker for human exposure to the carcinogenic nitrosamine 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in tobacco and tobacco smoke. In this work, an efficient and sensitive method for the analysis of NNAL in human hair was developed and validated. The hair sample was extracted by NaOH solution digestion, purified by C 18 solid-phase extraction (SPE) and molecularly imprinted solid-phase extraction, further enriched by reverse-phase ultrasound-assisted dispersive liquid-liquid microextraction (USA-DLLME) into 1.0 % aqueous formic acid, and finally analyzed by liquid chromatography-electrospray ionization tandem mass spectrometry. Good linearity was obtained in the range of 0.24-10.0 pg/mg hair with a correlation coefficient of 0.9982, when 150 mg hair was analyzed. The limit of detection and lower limit of quantification were 0.08 and 0.24 pg/mg hair, respectively. Accuracies determined from hair samples spiked with three different levels of NNAL ranged between 87.3 and 107.7 %. Intra-and inter-day relative standard deviations varied from 4.1 to 8.5 % and from 6.9 to 11.3 %, respectively. Under the optimized conditions, an enrichment factor of 20 was obtained. Finally, the developed method was applied for the analysis of NNAL in smokers' hair. The proposed sample preparation procedure combining selectivity of two-step SPE and enrichment of DLLME significantly improves the purification and enrichment of the analyte and should be useful to analyze NNAL in hair samples for cancer risk evaluation and cancer prevention in relation to exposure to the tobaccospecific carcinogen NNK.

show abstract

“…However, the most common application of DLLME is analysis of aqueous samples. In 2010, Hashemi et al developed reversed-phase (RP) DLLME, a variation of DLLME in which target compounds are directly extracted from lipid samples into extractant [41]. In recent years, the use of RP-DLLME for analyzing oil samples has increased because the required amount of toxic solvent is low and because the extractants have good compatibility with RP-HPLC mobile phase as well as capillary electrophoresis buffer [42].…”

Section: Introductionmentioning

confidence: 99%

Dual dispersive liquid–liquid microextraction for determination of phenylpropenes in oils by gas chromatography–mass spectrometry

Tsai

Feng

2015

Journal of Chromatography A

View full text Add to dashboard Cite

Reversed-phase dispersive liquid–liquid microextraction with central composite design optimization for preconcentration and HPLC determination of oleuropein

Cited by 83 publications

References 22 publications

Liquid-phase microextraction combined with graphite furnace atomic absorption spectrometry: A review

Liquid-phase microextraction combined with graphite furnace atomic absorption spectrometry: A review

Development, validation, and application of a liquid chromatography–tandem mass spectrometry method for the determination of 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanol in human hair

Dual dispersive liquid–liquid microextraction for determination of phenylpropenes in oils by gas chromatography–mass spectrometry

Contact Info

Product

Resources

About